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BONE TUMORS
Bone tumors
 Bone tumors are classified into:
 Primary bone tumors
 Secondary bone tumors ( Metastasis)
 Most are classified according to the normal cell of
origin and apparent pattern of differentiation
Histologic Type Benign Malignant
Hematopoietic (40%) Myeloma
Malignant lymphoma
Chondrogenic (22%) Osteochondroma Chondrosarcoma
Chondroma Dedifferentiated chondrosarcoma
Chondroblastoma Mesenchymal chondrosarcoma
Chondromyxoid fibroma
Osteogenic (19%) Osteoid osteoma Osteosarcoma
Osteoblastoma
Unknown origin (10%) Giant cell tumor Ewing tumor
Giant cell tumor
Adamantinoma
Histiocytic origin Fibrous histiocytoma Malignant fibrous histiocytoma
Fibrogenic Metaphyseal fibrous defect (fibroma) Desmoplastic fibroma
Fibrosarcoma
Notochordal Chordoma
Vascular Hemangioma Hemangioendothelioma
Hemangiopericytoma
Lipogenic Lipoma Liposarcoma
Neurogenic Neurilemmoma
Analytic approach to evaluation of the
bone neoplasm
Evaluation
 History
 Physical examination
 Investigations; labs, imaging
 Biopsy
Radiography
 Information yielded by radiography includes :
Site of the Lesion
Borders of the lesion/zone of transition
Type of bone destruction
Periosteal reaction
Matrix of the lesion
Nature and extent of soft tissue involvement
Distribution of various
lesions in a long tubular
bone in a growing skeleton
Site of the lesion.
Distribution of various lesions
in a long tubular bone after
skeletal maturity
Borders of the lesion
determine its growth rate.
sharp sclerotic sharp lytic ill-defined.
Malignant lesions are seen
predominantly in its anterior
part (body)
istribution of various lesions in a vertebra.
Benign lesions predominate
in its posterior elements.
An uninterrupted periosteal reaction usually indicates a benign process,
whereas an interrupted reaction indicates a malignant or aggressive
nonmalignant process
Types of periosteal reaction.
Interrupted type of periosteal reaction
sunburst
pattern -
osteosarcoma
lamellated or
onion-skin
type in ewing
sarcoma
Ewing sarcoma -
lamellated type
Codman
triangle
(arrow)
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt
18- BONE TUMORSDr.sib good education ppt

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18- BONE TUMORSDr.sib good education ppt

  • 2. Bone tumors  Bone tumors are classified into:  Primary bone tumors  Secondary bone tumors ( Metastasis)  Most are classified according to the normal cell of origin and apparent pattern of differentiation
  • 3.
  • 4. Histologic Type Benign Malignant Hematopoietic (40%) Myeloma Malignant lymphoma Chondrogenic (22%) Osteochondroma Chondrosarcoma Chondroma Dedifferentiated chondrosarcoma Chondroblastoma Mesenchymal chondrosarcoma Chondromyxoid fibroma Osteogenic (19%) Osteoid osteoma Osteosarcoma Osteoblastoma Unknown origin (10%) Giant cell tumor Ewing tumor Giant cell tumor Adamantinoma Histiocytic origin Fibrous histiocytoma Malignant fibrous histiocytoma Fibrogenic Metaphyseal fibrous defect (fibroma) Desmoplastic fibroma Fibrosarcoma Notochordal Chordoma Vascular Hemangioma Hemangioendothelioma Hemangiopericytoma Lipogenic Lipoma Liposarcoma Neurogenic Neurilemmoma
  • 5. Analytic approach to evaluation of the bone neoplasm
  • 6. Evaluation  History  Physical examination  Investigations; labs, imaging  Biopsy
  • 7. Radiography  Information yielded by radiography includes : Site of the Lesion Borders of the lesion/zone of transition Type of bone destruction Periosteal reaction Matrix of the lesion Nature and extent of soft tissue involvement
  • 8.
  • 9.
  • 10. Distribution of various lesions in a long tubular bone in a growing skeleton Site of the lesion. Distribution of various lesions in a long tubular bone after skeletal maturity
  • 11. Borders of the lesion determine its growth rate. sharp sclerotic sharp lytic ill-defined.
  • 12. Malignant lesions are seen predominantly in its anterior part (body) istribution of various lesions in a vertebra. Benign lesions predominate in its posterior elements.
  • 13. An uninterrupted periosteal reaction usually indicates a benign process, whereas an interrupted reaction indicates a malignant or aggressive nonmalignant process Types of periosteal reaction.
  • 14. Interrupted type of periosteal reaction sunburst pattern - osteosarcoma lamellated or onion-skin type in ewing sarcoma Ewing sarcoma - lamellated type Codman triangle (arrow)