The drug discovery process involves 5 main steps: 1. Discovery and screening of 10,000-20,000 candidate drugs through high-throughput screening and target validation to identify potential lead compounds. 2. Lead optimization using techniques like combinatorial chemistry and structure-based drug design to improve the properties of the lead compounds. 3. ADMET studies to evaluate the absorption, distribution, metabolism, excretion, and toxicity of the leads. 4. Clinical trials to test the safety and efficacy of potential drug candidates on humans. 5. New drug application to regulatory agencies like the FDA for market approval if clinical trials are successful, resulting in one new drug reaching the market.

1. Drug Discovery Process – Style 7
10,000 – 20,000 candidate drugs
Discovery &
Screening Step 1
High throughput
screening & target
validation Lead Optimization
Step 2 combinatorial
chemistry/ structure-
based drug design
ADMET
Adsorption, distribution, Step 3
metabolism, excretion,
toxicity studies
Step 4 Clinical Trials
Step 5
NDA Approved
1 Drug to
Market
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