A large international team of scientists led by Professor Jonathan Flint identified genetic sequences linked to major depressive disorder (MDD). The findings could help better diagnose and classify depression through early identification. Specific genes were identified, including LHPP and one near SIRT1, suggesting mitochondria may play a role in depression. The research analyzed over 10,000 Han Chinese women and could help develop more effective drugs and change perceptions of depression.

1. DECODING DEPRESSION
RESEARCHER MAY HAVE FINALLY FOUND
THE PATH TO DECODE ONE OF THE MOST
COMPLEX ILLNESSES, KNOWN TO BE THE
LEADING CAUSE OF DISABILITY WORLDWIDE
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2. THE LINK
• Genetic sequences linked to major depressive
disorder (MDD) were identified in a study
undertaken by a large team of scientists
spread across continents led by Professor
Jonathan Flint, a geneticist from University of
Oxford
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3. GAME CHANGER
• The findings will pave the way for better
diagnosis of the disease. It can help in early
identification, classification and prevention of
MDD. The study is also scientific proof that
depression can run in families The breakthrough
will help in developing effective drugs This will
also change the perception about depression, as
it has had a long standing stigma associated with
it, just as cancer patients were silent about their
condition earlier
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4. THE GENETIC SEQUENCES
• LHPP– a gene that codes for an enzyme whose
function is not fully understood
• A sequence next to the gene SIRT1, which is
important for energy-producing cell structures
called mitochondria and believed to combat
ageing
• The discovery suggests mitochondria may be
somehow involved in depression as well as
other gene mutations
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5. WHAT IS DEPRESSION?
• Depression is a common mental disorder
symptoms of which are depressed mood, loss
of interest or pleasure, decreased energy,
feelings of guilt or low self-worth, disturbed
sleep or appetite, and poor concentration
Depression is the leading cause of disease
burden globally, 50 per cent higher for females
than males
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6. THE ROAD AHEAD
• The research, which analysed the complete
DNA of over 10,500 Han Chinese women,
around half of who had MDD will serve as a
framework for future studies
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7. DEPRESSING NUMBERS
• Depression is the biggest cause of disability
worldwide, and as many as two-thirds of
those who commit suicide said to have the
condition According to a WHO report, the
prevalence of depression in India is around
four per cent. But there is only less than one
psychiatrist for every one lakh people
According to NCRB data for 2014, various
kinds of illnesses accounted for 18% of
suicides during 2014
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