3. Effects of alcohol Possible muscle disorder. Repeated ruptures,contractures, etc. Lowers the sensitivity threshold of fatigue. musculature Increase the frequency of the pulse, cardiac output and blood pressure by 30 '. Deleterious effect on the corazión. . Does not change significantly either blood pressure or cardiac output.. Cutaneous vasodilation (warm and red skin). Cardiovascular Depression Creative and intellectual decline, Personality deterioration Inhibition of pain. Dulling of reflexes. Nervous system excess small Quantities