1. 1
Oscar R. Miranda, PhD Address
SENIOR BIOMEDICAL & PHARMACEUTICAL ENGINEER Massachusetts Institute of Technology (MIT)
ormirandas@gmail.com 77 Massachusetts Avenue, Cambridge, MA 02139
http://web.mit.edu/nelman/www/page3/index.html
(US Permanent Resident)
_______________________________________________________________________________
Summary
• Innovative and highly-dedicated to passion for research and development of bio-sensing, drug formulation and platforms
solutions through cellular manipulation and therapy in providing early disease detection for ongoing prevention treatment
against fatal diseases and illnesses.
• 15+ years of experience research sciences and developments, dedicated last 10 years of scientific contributions to
micro/nano therapeutics, bio-sensing, investigate and formulate self-emulsifying drug delivery systems.
• Written grants proposals, protocol for mice models, patent applications, review articles, and research articles on a variety
of topics.
• Extensive experience in teaching: Managed +1000 students from various disciplines of engineering, science and
biomedical engineering as a teaching assistant.
• Extensive hands-on experience with bio/nanomaterial synthesis and surface modification, bio-conjugation, drug delivery
platforms, cell culture, engineering cells surface, DNA/aptamers, peptide synthesis, protein modification, circle rolling
amplification, cell surface up taking, 3-D printer, solid work package design, organic synthesis, nanoparticles, biopolymer
particles, hydrogels, liposomes/alginate systems, optoelectronic assay, immune and biological assays, micro-fluidic
systems, bio-sensing, confocal microscopy, microtome, analytical characterization, protein/biochemical/cell-based assay
develop, animal protocols, animal models, etc.
• Possess strong record of publications in high impact journals such as Nature Nanotech., Nature Chemistry, Nature
Protocols, Angew. Chem., Nano Letters, JACS, PNAS, ACS Nano, Nanomedicine, PLoS One, Adv. Mater., etc. (44+),
and conference/Invited presentations (26+).
• Inventor and medical solving problems (2+ Patents).
• Recipient of several prestigious awards and grant (8)
• Being honored to be safety officer on different Alma Mater laboratories including Villanova, UMass-Amherst, Harvard,
BWH and MIT.
• Proven capability in leading a project, managing multiple projects simultaneously, ability to lead multifunctional project
teams, ability to drive for continuous-process improvement, work effectively in a multi-tasking environment, working well
both in groups and independently, dedicated and attentive to successfully endeavor any assigned task, motivated self-
starter with a "can-do" attitude, resourceful individual who maintains a positive, proactive attitude when faced with
adversity, and have access to a network of experts in different fields including Medicine, Health Care, Science,
Technology, Engineering, and Industry.
_________________________________________________________________________________________________
Research of Interest
Main interest: Drug Delivery, Biomaterials, Cell Therapy, Bio-Medical Engineering, Translational Medicine
Areas of Interest: Arthritis, Diabetes, Cancer (e.g. Lung Cancer, Neuroblastoma, Breast Cancer, Prostate Cancer),
Regenerative Medicine, Surface Engineering, Cell Interactions, Cell Microenvironments, Diagnostics, Biosensors,
Imaging, Biomarkers, Aptamers, Micro- and Nano-technology, Bio-conjugation, Treatment of Diseases.
Objective
• To develop and use molecular and bioengineering tools with emphasis on small materials and bio-inspired biology
in order to further understand, diagnose, image, and treat diseases to tackle unmet challenge in medical needs
including but not limited to Inflammatory Arthritis, Diabetes and Cancer Subtypes.
• To work in the interface between chemistry, material science and engineering, and biology in collaboration with an
interdisciplinary team including clinicians, pharmacologists, medical doctors and bioengineers to a) develop the
next generation of macro/nano drug delivery systems to deliver drugs to patients in a safe, effective, and
compliant manner; b) study biological, therapeutic, and detrimental functions of cell-based systems to better

2. 2
understand and utilize them to treat a variety of diseases; and c) synthesize, develop and engineer biomaterials
for therapeutic applications in biomedicine.
Education
Post-Doctoral Associate in Biomedical Devices & Translational Research, with Dr. Noel Elman 03/2014-Present
Massachusetts Institute of Technology (MIT)
Institute for Soldier Nanotechnologies
Cambridge, Massachusetts, USA.
• Developing, designing (e.g. Solid work software), re-engineering, and 3D printing biomedical devices prototypes
for rapid microfluidic reconstitution of lyophilized drugs such as vaccines, antibiotics, and emergency medications
for controlled release in rural areas, ambulatory setting, ERs, and disaster zones. This rapid reconstitution
technology is for dramatically advancing soldier protection and survivability capabilities however it could have dual
use for military and civilian applications. Emphasis of this medical device is on drugs that cannot be practically
refrigerated today, allowing for the use of these drugs beyond their current ability.
• Developing a portable biomarker medical device-using novel assays based on QDs and integrated electro-optics
system. This technological platform combine the use of functionalized quantum dots and an optical-electronic
platform (fiber optics-electro transducer system) for the detection of biomarkers e.g. cortisol, epinephrine. This
project has the potential to make a social impact for home detection of cardiac, endocrine and cancer biomarkers.
Post-Doctoral Research Fellow in BioMedical Engineering, with Prof. Jeffrey M. Karp 11/2010-02/2014
Division of Biomedical Engineering, Department of Medicine
Center for Regenerative Therapeutics
Brigham and Women’s Hospital, Harvard Medical School,
Harvard Stem Cell Institute and Harvard-MIT Health Sciences and Technology (HST)
Cambridge, Massachusetts, USA.
• Developing and establishing long-acting, sustainable, and efficient micro- and nanoparticle systems to deliver
drugs. In this study male SPF Sprague-Dawley rats were used.
• Developing FRET aptamer biosensors that can detect insulin secretion in real-time in vivo from transplanted β-
cells (or their precursors). In this study the mouse anterior chamber model is used.
• Engineering cell surfaces to target inflamed pancreas in diabetic mice and monitor their homing to the targeted
place as a “Zip Code”. In this study diabetic mouse models are used.
• Engineering Mesenchymal Stem Cells (MSCs) to deliver cargos to inflamed areas. In this study mouse models
are used.
• Developing a smart biologically responsive hydrogel platform that releases drugs in response to local expression
of enzymes (e.g. MMP-2/MMP-9) that correlates with the level of inflammation in arthritis (Rheumatoid Arthritis).
In this study mouse models with induced knee inflammation will be used.
• Immobilizing contract agents on implantable human vein graft for enhancement of vessel wall in MR Imaging.
PhD in Chemistry (Organic/Nanomaterials/Biology), with Prof. Vincent M. Rotello Feb-2011
University of Massachusetts-Amherst, Massachusetts, USA.
• Developed a “chemical nose” technological platform for identifying and detecting cellular components such as
proteins, bacteria and cancerous cells as potential medical tool for the early diagnosis of diseases and successful
treatment of patients.
• Designed, synthesized, and characterized new small bio-molecules library for biological applications.
• Synthesized and characterized nanoparticles library for biological applications.
• Engineered nanoparticles surface for biological applications.
• Established a functionalized nanoparticle library for biological applications.
• Studied nanoparticles’ charge effect on the plasma membrane, up-taking, bio-distribution and pharmacokinetic
profile in vitro and in vivo models.
MSc in Chemistry (Physical Chemistry/Nanomaterials), with Prof. Temer S. Ahmadi Sept-2005
Villanova University, Pennsylvania, USA.
• Studied the effects of intensity and energy of CW UV light on the nucleation and growth of gold nanorods
(AuNRs).
• Studied the critical concentrations and role of ascorbic acid (Vitamin C) in the crystallization of gold nanorods
within hexadecyltrimethyl ammonium bromide (CTAB)/tetraoctyl ammonium bromide (TOAB) micelles.

3. 3
Post-graduate in Business Administration (MBA), with Prof. Ivan Ortiz April-2000
Central American University (UCA), Managua, Nicaragua.
• Determined the competitive and comparative advantages of dairy product clusters in Nicaragua.
BE in Chemical Engineering Sept-1997
With Dr. Ricardo J. Alvarado and Drs. Gabriele and Nikolaus Foidl
National University of Engineering (UNI), Managua, Nicaragua.
• Studied the extraction of polyelectrolyte (cationic biopolymer) of Moringa Oleifera seeds and their purification in
ultra-filtration of cross-flux and optimization processes using jar test for the treatment of stabilization lakes.
Patents
1. Vincent M. Rotello; Uwe H. F. Bunz; Ronnie L. Phillips; Oscar R. Miranda; Chang-Cheng You. Novel Sensors for
Detection of Pathogens, US Application Serial No. 12/313137.
2. Vincent M. Rotello; Uwe H. F. Bunz; Chang-Cheng You; Oscar R. Miranda; Ik-Bum Kim. Detection of Proteins using
Nanoparticle-Fluorescent Polymer Sensors, US Application Serial No. 12/313116.
3. Vincent M. Rotello; Uwe H. F. Bunz; Oscar R. Miranda; Avinash Bajaj; Subinoy Rana; Detection of
Normal/Cancerous/Metastatic Cells using Nanoparticle-Polymer and Nanoparticle-GFP Supramolecular
Complexes. UMA 09-40, Patent Filed, In process.
Awards and Honors
2013 Rheumatology Research Workshop Scholarship Award (ACR and AF), $1,000 June-2013
Brigham and Women’s Hospital-Harvard Medical School
Arthritis Foundation Post-Doctoral Fellowship Award (PF), $100,000 July-2012
Brigham and Women’s Hospital-Harvard Medical School
Translational Medicine Scholarship June-2012
Harvard Catalyst: The Harvard Clinical and Translational Science Center,
Harvard Medical School
NIH 2012 Beta Cell Biology Consortium (BCBC) Retreat Scholarship Award, $1,000 May-2012
Harvard-MIT (HST), Harvard Stem Cell Institute (HSCI),
Brigham and Women's Hospital and Harvard Medical School
William E. McEwen Outstanding Graduate Student Award, $500 Sept-2009
University of Massachusetts-Amherst
Graduate Student Travel Grant Award, $300 July-2008
University of Massachusetts-Amherst
1
st
Place SIGMA Xi Research Day May-2005
Villanova University Chapter
Graduate Student Travel Grand Award, $ 500 2x ($1,000) March-2005
Villanova University
Professional Experience
Research Assistant and Teaching Assistant in Chemistry 10/2005 - 10/2010
University of Massachusetts, Amherst, MA 01003, USA
Chemistry Resource Center Instructor (Integrated Science) Fall 2009
University of Massachusetts, Amherst, MA 01003, USA
Visiting Research Assistant in Chemistry (Prof. Uwe H. F. Bunz) Spring 2008
Georgia Institute of Technology, Atlanta, GA 30332, USA
Research Assistant and Teaching Assistant in Chemistry 09/2002-06/2005
Villanova University, Villanova, PA 19085, USA
National Consultant to the United Nations Development 02/15/1997-08/15/2002

4. 4
Organization (UNIDO): Project UNIDO US/NIC/02/05,
Project UNIDO US/NIC/97/209 and Project UNIDO US/NIC/94/012
Managua, Nicaragua
Researcher, Austrian Project BIOMASS 08/06/1995-02/06/1997
(Austrian Technical Cooperation Organization SUCHER & HOLZER)
Managua, Nicaragua
National Technical Specialist in Patents of Inventions 01/15/1993-06/20/1995
Ministry of Economy and Development
Managua, Nicaragua
Laboratory Instructor in Chemical Engineering: 03/07/1994-11/25/1995
Organic, Thermodynamic, Mass and Heat Transfer
National University of Engineering
Managua, Nicaragua
Recognition
Diplomas of Recognition from 25 enterprises and an International 06/2000
Organization from the World Bank, for helping in the development of microeconomic
systems in Nicaraguan rural areas.
United Nations Development Organization (UNIDO)
Project UNIDO US/NIC/02/05,Project UNIDO US/NIC/97/209 and
Project UNIDO US/NIC/94/012
Managua, Nicaragua
Professional Affiliation
American Diabetes Association, Member 2013-Present
American College of Rheumatology (ACR), Member 2013-Present
The Endocrine Society, Member 2013-Present
American Association for Cancer Research (AACR) 2013-Present
Federation of American Societies for Experimental Biology (FASEB), Member 2013-Present
American Association of Pharmaceutical Scientists (AAPS), Member 2013-Present
Biomedical Engineering Society (BMES), Member 2011-Present
International Society for Stem Cell Research (ISSCR), Member 2011-Present
Controlled Drug Release Society (CRS), Member 2011-Present
Society for Biomaterials, Member 2011-Present
American Institute of Chemical Engineering (AIChE), Member 2011-Present
Materials Research Society (MRS), Member 2005-Present
American Physics Society (APS), Member 2005-Present
Sigma Xi, The Scientific Research, Member 2004-Present
American Chemical Society (ACS) Member 2003-Present
Publications & Presentations

5. 5
Refereed Journal Papers (Total papers: 44; Citations: 2675; h-index: 27; i10index: 39)
Published (Selective)
1. Pablo Gurman, Oscar R. Miranda, Kevin Clayton, Yitzhak Rosen, Noel Elman. Clinical Applications of Biomedical
Micro-devices for Controlled Drug Delivery. Mayo Clinic Proceedings 2015, 90(1):93-108.
2. James A. Ankrum, Oscar R. Miranda, Kelvin S. Ng, Debanjan Sarkar, Chenjie Xu, Jeffrey M. Karp. Engineering cells
with intracellular agent-loaded macroparticles to control cell phenotype. Nature Protocols 2014, 9, 233.
3. Subinoy Rana, Rubul Mout, Ngoc D. B. Le, Krishnendu Saha, Gülen Yesilbag Tonga, Oscar R. Miranda, Caren M.
Rotello, Vincent M. Rotello. Rapid Cell-Based Mechanistic Profiling of Cancer Therapeutics Using a Multichannel
Nanosensor. Nature Nanotech 2014, Accepted (Paper #NNANO-14050870B).
4. Pablo Gurman, Oscar R. Miranda, Alexandra Nathan, Cyrus Washington, Yitzhak Rosen, Noel Elman. Recombinant
Tissue Plasminogen Activators (rtPA): A review. Clinical Pharmacology & Therapeutics 2014, Accepted (Paper
#2014-0528R).
5. Praveen K. Vemula, Nikken Wiradharma, James A. Ankrum, Oscar R. Miranda, George John, Jeffrey M. Karp. Pro-
drugs as self-assembled hydrogels: A new paradigm for biomaterials, Curr. Opin. Biotechnol. 2013, 24, 1174.
6. Krishnendu Saha, Sung Tae Kim, Bo Yan, Oscar R. Miranda, Felix S. Alfonso, Denis Shlosman and Vincent M.
Rotello. Surface Functionality of Nanoparticles Determines Cellular Uptake Mechanisms in Mammalian Cells, Small
2013, 9, 300.
7. Subinoy Rana, Arvind K. Singla, Avinash Bajaj, S. Gokhan Elci, Oscar R. Miranda, Rubul Mout, Bo Yan, Frank R.
Jirik, and Vincent M. Rotello. Array-Based Sensing of Metastatic Cells and Tissues Using Nanoparticle-Fluorescent
Protein Conjugates. ACS Nano 2012, 6, 8233.
Journal Impact Factor
(2013)
Nature Nanotechnology 33.265
Nature Chemistry 23.297
Advanced Materials 15.409
Nano Letter 12.940
ACS Nano 12.033
JACS 11.444
Angewandte Chemie International Edition 11.336
PNAS 9.809
Chemical Science 8.601
Current Opinion in Biotechnology 8.035
Nature Protocols 7.782
Current Opinion in Chemical Biology 7.652
Small 7.514
Clinical Pharmacology & Therapeutics 7.390
Chemical Communications 6.718
Nanomedicine 5.824
Mayo Clinic Proceedings 5.812
BioMacromolecules 5.788
Chemistry: A European Journal 5.696
Environmental Science and Technology 5.481
Crystal Growth and Design 4.558
Langmuir 4.384
Soft Matter 4.151
Analytical and Bioanalytical Chemistry 3.578
Plos One 3.534
Journal of Physical Chemistry B 3.377

6. 6
8. Rochelle R. Rochelle; Karuna Giri; Daniel Moyano; Oscar R. Miranda; Benjamin Madden; Daniel J. McCormick;
Resham Bhattacharya; Vincent M. Rotello; Jean-Pierre Kocher; Priyabrata Murkherjee. Identifying New Therapeutic
Targets via Modulation of Protein Corona Formation by Engineered Nanoparticles, PLoS One 2012, 7, e33650.
9. Rochelle R. Arvizo; Oscar R. Miranda; Daniel F. Moyano; Chad A. Walden; Karuna Guri; Resham Bhattacharya; J.
David Robertson; Vincent M. Rotello; Joel M. Reid; Priyabrata Mukherjee. Modulating Pharmacokinetics, Tumor
Uptake and Biodistribution by Engineered Nanoparticles, PLoS One 2011, 6, e24374.
10. Oscar R. Miranda; Xiaoning Li; Zheng-Jiang Zhu; Bo Yan; Uwe H. F. Bunz; Vincent M. Rotello. Colorimetric bacteria
sensing using a supramolecular enzyme-nanoparticle biosensor, J. Am. Chem. Soc. 2011, 133, 9650.
11. Rochelle R. Arvizo; Subinoy Rana; Oscar R. Miranda; Resham Bhattacharya; Vincent M. Rotello; Priyabrata
Mukherjee. Mechanism of anti-angiogenic property of gold nanoparticles: Role of nanoparticle size and surface
charge, Nanomedicine, 2011, 7, 580. (Front Cover Picture).
12. Oscar R. Miranda; Brian Creran; Vincent M. Rotello. Array-based sensing with nanoparticles: “Chemical noses” for
sensing biomolecules and cell surfaces. Curr. Opin. Chem. Bio. 2010,14, 728.
13. Rochelle R. Arvizo; Oscar R. Miranda; Michael A. Thompson; Christina M. Pabelick; Resham Bhattacharya; J. David
Robertson; Vincent M. Rotello; Y. S. Prakash; Priyabrata Mukherjee. Effect of nanoparticle surface charge at the
plasma membrane and beyond, Nano Lett. 2010, 10, 2543.
14. Chandramouleeswaran Subramani; Avinash Bajaj; Oscar R. Miranda; Vincent M. Rotello. Biocompatible charged
and uncharged surfaces using nanoparticle Films. Adv. Mat. 2010, 22, 5420.
15. Oscar R. Miranda; Hung-Ting Chen; Chang-Cheng You; David E. Mortenson; Xiao-Chao Yang; Uwe H. F. Bunz;
Vincent M. Rotello. Enzyme amplified array sensing of proteins in solution and in biofluids, J. Am. Chem. Soc. 2010,
132, 5285.
16. Avinash Bajaj, Oscar R. Miranda; Ronnie L. Phillips, IK-Bum Kim; D. Joseph Jerry, Uwe H. F. Bunz; Vincent Rotello.
Array based sensing of normal, cancerous and metastatic cells using conjugated fluorescent polymers, J. Am.
Chem. Soc. 2010, 132, 1018.
17. Bo Yan; Zheng-Jiang Zhu; Oscar R. Miranda; Apiwat Chompoosor; Vincent M. Rotello; Richard W. Vachet. Laser
desorption/ionization mass spectrometry analysis of monolayer-protected gold nanoparticles, Anal. Bioanal. Chem.
2010, 396, 1025.
18. Avinash Bajaj; Subinoy Rana; Oscar R. Miranda; Joseph C. Yawe; D. Joseph Jerry; Uwe H. F. Bunz; Vincent M.
Rotello. Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based
sensing array, Chem. Sci. 2010, 1, 134.
19. Mrinmoy De; Subinoy Rana; Handan Akpinar; Oscar R. Miranda; Rochelle R. Arvizo; Uwe H. F. Bunz; Vincent M.
Rotello. Sensing of proteins in human serum using conjugates of nanoparticles and green fluorescence proteins
(GFP), Nature Chem. 2009, 1, 461. (Front Cover Picture)
20. Avinash Bajaj; Oscar R. Miranda; Ik-Bum Kim; Ronnie L. Phillips; D. Joseph Jerry; Uwe H. F. Bunz; ; Vincent M.
Rotello. Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor
arrays, Proc. Nat. Acad. Sci. (USA) 2009, 106, 10912. (Featured in Chem. & Eng. News (ACS), Science Daily,
Times of India, US News and many more) (Among top 20 most read articles in July 2009)
21. Mrinmoy De; Oscar R. Miranda; Subinoy Rana; Vincent M. Rotello. Size dependent protein-nanoparticle self-
assembly, Chem. Commun. 2009, 16, 2157.
22. Ronnie Phillips; Oscar R. Miranda; Ik-Bum Kim; David E. Mortenson; Chandramouleeswaran Subramani; Vincent M.
Rotello; Uwe H. F. Bunz. Gold nanoparticle-conjugated polymer constructs: Understanding the electrostatic and
hydrophobic interactions, Soft Matter 2009, 5, 607.
23. Zheng-Jiang Zhu; Partha S. Ghosh; Oscar R. Miranda; Richard W. Vachet; Vincent M. Rotello. Multiplexed
screening of the cellular uptake of gold nanoparticles using Laser Desorption/Ionization Mass Spectrometry (LDI-
MS), J. Am. Chem. Soc. 2008, 130, 14139.
24. Ronnie Phillips; Oscar R. Miranda; Chang-Cheng You; Vincent M. Rotello; Uwe H. F. Bunz. Rapid and efficient
identification of bacteria using gold-nanoparticle–poly(para-phenyleneethynylene) constructs, Angew. Chem. Int. Ed.
2008, 47, 2590. (Inside Cover Picture)

7. 7
25. Oscar R. Miranda; Chang-Cheng You; Ronnie Phillips; Ik-Bum Kim; Partha S. Ghosh; Uwe H. F. Bunz; Vincent M.
Rotello. Array-based sensing of proteins using conjugated polymers, J. Am. Chem. Soc. 2007, 129(32); 9856.
26. Chang-Cheng You; Oscar R. Miranda; Basar Gider; Partha S. Ghosh; Ik-Bum Kim; Belma Erdogan; Sai Archana
Krovi; Uwe H. F. Bunz; Vincent M. Rotello. Detection and identification of proteins using nanoparticles-fluorescent
polymer “chemical nose” sensors, Nature Nanotech. 2007, 2, 318.
27. Oscar R. Miranda; Norman R. Dollahon; Temer S. Ahmadi. Critical concentrations and role of ascorbic acid (Vitamin
C) in the crystallization of gold nanorods within hexadecyltrimethyl ammonium bromide (CTAB)/tetraoctyl ammonium
bromide (TOAB) micelles, Cryst. Growth Des. 2006, 6, 2747.
28. Oscar R. Miranda; Temer S. Ahmadi. Effects of intensity and energy of CW UV-Light on the growth of gold
nanorods, J. Phys. Chem. B 2005, 109, 15724
Additional published
29. Yi-Cheun Yeh; Krishnendu Saha; Bo Yan; Xi Yu; Oscar R. Miranda; Vincent M. Rotello. The Role of Ligand
Coordination on the Cytotoxicity of Cationic Quantum Dots. Nanoscale 2013, 5, 12140.
30. Zheng-Jiang Zhu; Rui Tang; Yi-Cheun Yeh; Oscar R. Miranda; Vincent M. Rotello; Richard W. Vachet.
Determination of the Intracellular Stability of Gold Nanoparticle Monolayers Using Mass Spectrometry, Anal. Chem.
2012, 84, 4321.
31. Steven C. Hayden; Gengxiang Zhao; Krishnendu Saha; Ronnie L. Phillips; Xiaoning Li; Oscar R. Miranda; Vincent
M. Rotello; Mostafa A. El-Sayed; Ingeborg Schmidt-Krey; Uwe H. F. Bunz. Aggregation and Interaction of Cationic
Nanoparticles on Bacterial Surfaces, J. Am. Chem. Soc. 2012, 134, 6920.
32. Daniel F. Moyano; Meir Goldsmith; David J. Solfiell; Dalit Landesman-Milo; Oscar R. Miranda; Dan Peer; Rotello,
Vincent M. Rotello. Nanoparticle Hydrophobicity Dictates Immune Response, J. Am. Chem. Soc. 2012, 134, 3965.
33. Xi Yu; Jonathan T. Pham; Chandramouleeswaran Subramani; Brian Creran; Yi-Cheun Yeh; Du; Debabatra Patra,
Oscar R. Miranda, Crosby AJ, Vincent M. Rotello. Direct Patterning of Engineered Ionic Gold Nanoparticles via
Nanoimprint Lithography. Adv Mater. 2012, 24, 6330.
34. Subinoy Rana; Xi Yu; Debabrata Patra; Daniel F. Moyano; Oscar R. Miranda; Irshad Hussain; Vincent M. Rotello.
Control of Surface Tension at Liquid-Liquid Interfaces Using Nanoparticles and Nanoparticle-Protein Complexes,
Langmuir 2012, 28, 2023.
35. Kaimin Chen; Yisheng Xu; Subinoy Rana; Oscar R. Miranda; Paul L. Dubin; Vincent M. Rotello; Lianhong Sun;
Xuhong Guo. Electrostatic selectivity in protein−nanoparticle interactions, Biomacromolecula 2011, 12, 2552.
36. Yi-Cheun Yeh; Debabrata Patra; Bo Yan; Oscar R. Miranda; Vincent M. Rotello. Synthesis of cationic quantum dots
via one/two step ligand exchange reaction. Chem. Comm. 2010, 47, 3069.
37. Psaras L. McGrier; Kyril M. Solntsev; Anthony J. Zucchero; Oscar R. Miranda; Vincent M. Rotello; Laren M. Tolbert;
Uwe H. F. Bunz. Hydroxydialkylamino Cruciforms: Amphoteric Materials with Unique Photophysical Properties,
Chem. Eur. J. 2011, 17, 3112.
38. Xiao-Chao Yang; Bappaditya Samantha; Sarit S. Agasti; Youngdo Jeong; Zheng-Jiang Zhu; Subinoy Rana; Oscar R.
Miranda; Zhi-Hong Mo; Vincent M. Rotello. Particle stabilized nanocapsule as a lipophilic drug carrier, Angew.
Chem. Int. Ed. 2011, 50, 477.
39. Apiwat Chompoosor; Krishnendu Saha; Partha S. Ghosh; Dylan J. Macarthy; Oscar R. Miranda; Zhenjiang Zhu;
Kathleen F. Arcaro; Vincent M. Rotello. DNA damage caused by cationic gold nanoparticles in mammalian cell: The
potential use of gold nanoparticles as therapeutics, Small 2010, 6, 2246.
40. Zheng-Jiang Zhu; Rachel Carboni; Michael Quercio; Bo Yan; Oscar R. Miranda; Douglas L Ardenton; Kathleen F.
Arcaro; Vincent M. Rotello; Richard W. Vachet. Effect of surface chemistry on uptake, distribution, and excretion of
nanomaterials by Japanese medaka. Small 2010, 6, 2261.
41. Debabrata Patra; Firat Ozdemir; Oscar R. Miranda; Bappaditya Samanta; Amitav Sanyal; Vincent M. Rotello.
Formation and size tuning of colloidal microcapsules via host−guest molecular recognition at the liquid−liquid
interface, Langmuir 2009, 25, 13852.

8. 8
42. Bappaditya Samanta; Xiao-Chao Yang; Yuval Ofir; Myoung-Hawn Park; Debabrata Patra; Sarit S. Agasti; Oscar R.
Miranda; Zhi-Hong Mo; Vincent M. Rotello. Catalytic microcapsules assembled from enzyme-nanoparticle
conjugates at oil-water interfaces, Angew. Chem. Int. Ed. 2009, 48, 5341.
43. Myoung-Hwan Park; Yuval Ofir; Bappaditya Samanta; Palaniappan Arumugam; Oscar R. Miranda; Vincent M.
Rotello. Nanoparticle immobilization on surfaces via activatable heterobifunctional dithiocarbamate bond formation,
Adv. Mat. 2008, 20, 4185.
44. Psaras L. McGrier; Kyril M. Solntsev; Shaobin Miao; Laren M. Tolbert; Oscar R. Miranda; Vincent M. Rotello; Uwe
H. F. Bunz. Hydroxycruciforms: amine-responsive fluorophores, Chem. Eur. J. 2008, 14, 4503. (Front Cover
Picture).
Submitted and in Preparation
1. Oscar R. Miranda, Hilla Conen, Noel M. Elman. Rapid Reconstitution Packages (RRPs) for Emergency Delivery
of Glucagon. 2015, Submitted.
2. David Veysett, Oscar R. Miranda, Pablo Gurman, Roni Cantor, Keith Nelson, Noel M. Elman. Laser Activated
Nanoparticle Delivery for Tumor Therapy. 2015, In preparation.
3. Oscar R. Miranda, Keith Whitaker, Kaleb G. MacDowell, Moungi Bawendi, Noel M. Elman. Quantum-Dot based
Assay for Rapid and Specific Ex Vivo Detection of Salivary Cortisol. 2014, In Preparation.
4. Oscar R. Miranda
†
, Hilde De-Man
†
, Bryan E. Laulicht, Patrick Sterkens, Praveen K. Vemula, Weian Zhao, James A.
Ankrum, Kelvin S. Ng, Nikken Wiradharma, Shrey Sindhwani, Liang Zhang, Lijie Zhang, Chenjie Xu, Katie Amssoms,
Jeffrey M. Karp*. Long-acting injectable drug delivery matrix system: A TCM15 pharmacokinetic “in vivo”
study for HIV treatment, 2015, In preparation.
5. Dimitrios Mitsouras, Ming Tao, Oscar R. Miranda, Frank J. Rybicki III, Charles K. Ozaki, Jeffrey M. Karp, Peng Yu,
Praveen Vemula, Chenwei Liu, Robert Mulkern. Vein grafts implantable contrast MRI Initiative: Enhanced Vessel
Wall Imaging, 2015, In Preparation.
6. Oscar R. Miranda
†
, Oren Levy
†
, Yen Sun, Luke Mortensen, Kelvin Ng, Shrey Sindhwani, Nikken Wiradharma, Jason
Gaglia, Stephan Kissler, Charles Lin and Jeffrey M. Karp*. Engineering MIN6 cells surface to target inflamed
pancreas in diabetic mice models: A novel zip code approach for pancreatic cells transplantation, 2015, In
process.
7. Oscar R. Miranda; Shrey Sindhwani; Sandy Spurr-Michaud; Bryan Laulicht, Eoin O’Cearbhaill, James A. Ankrum,
Grace Sock Leng Teo, Ilene K. Gipson; Jeffrey M. Karp*. Surface engineering and size effect of mucoadhesive
particles for ophthalmic drug delivery in an “in vitro” ocular cells model, 2015, In process.
8. Oscar R. Miranda
†
; Praveen K. Vemula
†
; Anita Tseng Shaw; Ellen M. Gravallese; Antonios Aliprantis; Jeffrey M.
Karp*. Inflammation responsive hydrogels for treatment of inflammatory arthritis, 2015, In process.
Conference presentations
1. Oscar R. Miranda, Frank J. Rybicki III, Charles K. Ozaki, Jeffrey M. Karp, Peng Yu, Dimitrios Mitsouras, Praveen
Vemula, Ming Tao, Chenwei Liu, Robert Mulkern. Vein grafts implantable contrast MRI Initiative: Enhanced Vessel
Wall Imaging. 99
th
Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA),
Chicago, IL, United Stated, December 1-6, 2013.
2. Oscar R. Miranda, Praveen K. Vemula, Oren Levy, Michael Valic, Priya Anand, Ellen M. Gravallese, Antonios O.
Aliprantis, Jeffrey M. Karp. Biologically responsive hydrogels: A new approach for treatment of inflammatory arthritis,
2013 Rheumatology Research Workshop (American College of Rheumatology (ACR) and Arthritis Foundation (AF)),
Dallas, TX, United States, June 21-23, 2013.
3. Oscar R. Miranda, Praveen K. Vemula, Oren Levy, Michael Valic, Priya Anand, Ellen M. Gravallese, Antonios O.
Aliprantis, Jeffrey M. Karp. Biologically responsive hydrogels: A new approach for treatment of inflammatory arthritis,
BWH BRI Regenerative Medicine Center Symposium, Boston, MA, United States, June 11, 2013.
4. Oscar R. Miranda, Yen Sun, Shrey Sindhwani, Kelvin Ng, Maike Sander, Charles Lin, Jeffrey M. Karp. Development
of an approach to monitor real-time insulin secretion in vivo at the single cell level, NIH 2012 Beta Cell Biology
Consortium (BCBC) Retreat, Chantilly, VA, United States, May 1-4, 2012.

9. 9
5. Oscar R. Miranda; Avinash Bajaj; Sukru G. Elci; Subinoy Rana; Krishnendu Saha; Ronnie L. Phillips; Jonathan J.
Bryant; Ik-Bum Kim; D. Joseph Jerry; Uwe H. Bunz; Vincent M. Rotello. FRET based pattern recognition of isogenic
cells differing in cell surface glycans. ORGN-694, CODEN: 69NAQG, 240th ACS National Meeting, Boston, MA,
United States, August 22-26, 2010.
6. Oscar R. Miranda; Xiaoning Li; Zheng-Jiang Zhu; Bo Yan; Uwe H. F. Bunz; Vincent M. Rotello. Colorimetric bacteria
sensing using a hybrid enzymatic nanocomposite biosensor. COLL-46, CODEN: 69NAQG, 240th ACS National
Meeting, Boston, MA, United States, August 22-26, 2010.
7. Oscar R. Miranda; Hung-Ting Chen; Chang-Cheng You; David E. Mortenson; Vincent M. Rotello. A novel gold
nanoparticle-based protein sensor with enzyme-substrate reactions as signal amplifiers. COLL-131, CODEN:
69KXQ2, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008.
8. Oscar R. Miranda; Hung-Ting Chen; Chang-Cheng You; Ronnie L. Phillips; Ik-Bum Kim; Uwe H. F. Bunz; Vincent M.
Rotello. “Chemical nose” sensing and identification of proteins and bacteria. III International Symposium on
Microcyclic and Supramolecular Chemistry (ISMSC), Las Vegas, NV, United States, July 13-18, 2008.
9. Oscar R. Miranda; Chang-Cheng You; Ronnie L. Phillips; Ik-Bum Kim;Partha S. Ghosh; Uwe H. F. Bunz; Vincent M.
Rotello. Ultraversatile protein sensor based on an array of conjugated polymers. ORGN-227, CODEN: 69JNR2; 234th
ACS National Meeting, Boston, MA, United States, August 19-23, 2007.
10. Oscar R. Miranda; Temer S. Ahmadi. Substrate-Assisted Phase Transitions of Au Nanorods. GENE-520, CODEN:
69GVWG; 37th Middle Atlantic Regional Meeting of the American Chemical Society, New Brunswick, NJ, United
States, May 2005.
11. Oscar R. Miranda; Riffard Jean-Gilles; Temer Ahmadi. Nucleation and Growth of Gold Nanorods. Villanova
University, Sigma Xi Research Day, Villanova, PA, United States, April 2005.
12. Oscar R. Miranda; Riffard Jean-Gilles; Temer S. Ahmadi. Growth Kinetics of Gold Nanorods. The16
th
Annual Saint
Josepth’s University SIGMA XI, Student Research Symposium, Philadelphia, PA, United States, April 2005.
13. Oscar R. Miranda; Riffard Jean-Gilles; Temer S. Ahmadi. Effects of Chemical and Physical Parameters on the
Growth Kinetics of Gold Nanorods. PHYS-384, CODEN: 69GQMP; 229th ACS National Meeting, San Diego, CA,
United States, March 2005 (Science Mix).
14. Oscar R. Miranda; Temer S. Ahmadi. Mechanism and Growth Kinetics of Colloidal Gold Nanoparticles, COLL-076,
CODEN: 69FTZ8; 228
th
ACS National Meeting, Philadelphia, PA, United States, August 2004.
15. Oscar R. Miranda; Temer S. Ahamadi. 2- and 3-Dimentional Assembly of Shape-selected and Surface-modified Au
Nanoparticles: Nature of Packing and its Correlation to Optical Properties; PHYS-360, CODEN 69EKY9; 226
th
ACS
National Meeting, New York City, NY, United States, September 2003.
Other Conference Presentations
16. Rochelle R. Arvizo; Subinoy Rana; Oscar R. Miranda; Resham Bhattacharya; Vincent M. Rotello; Priyabrata
Mukherjee. Mechanism of anti-angiogenic property of gold nanoparticles: Role of nanoparticle size and surface
charge. COLL-295. CODEN: 69NAQG, 240th ACS National Meeting, Boston, MA, United States, August 22-26,
2010.
17. Xi Yu; Kan Du; Craig Versek; Debabrata Patra; Oscar R. Miranda; Anthony D. Dinsmore; Mark T. Tuominen; Vincent
M. Rotello. Soft and deformable gold nanoparticles with unique conducting properties. ORGN-832. CODEN:
69NAQG, 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010.
18. Subinoy Rana; Avinash Bajaj; Oscar R. Miranda; Joseph C. Yawe; D. J. Jerry; Uwe H. Bunz; Vincent M. Rotello.
Cell-surface and lysate based identification of cell types and cancer states using gold nanoparticle-GFP
supramolecular complexes. ORGN-260, CODEN: 69NAQG, 240th ACS National Meeting, Boston, MA, United States,
August 22-26, 2010.
19. Zheng-Jiang Zhu; Bo Yan; Oscar R. Miranda; Richard W. Vachet; Vincent M. Rotello Characterization and tracking of
monolayer-protected nanoparticles in biological systems using mass spectrometry. COLL-234, CODEN: 69NAQG,
240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010.
20. Subinoy Rana; Mrinmoy De; Oscar R. Miranda; Uwe H. Bunz; Vincent M. Rotello. Array based sensing of proteins
in human serum using nanoparticle-green fluorescent protein conjugates. COLL-48, CODEN: 69NAQG, 240th ACS
National Meeting, Boston, MA, United States, August 22-26, 2010.

10. 10
21. Zheng-Jiang Zhu; Rachel Carboni; Michael Quercio; Bo Yan; Oscar R. Miranda; Kathleen F. Arcaro; Richard W.
Vachet; Vincent M. Rotello. Effect of surface chemistry on uptake, distribution and excretion of nanomaterials by
Japanese medaka. INOR-721, CODEN: 69NAQG, 240th ACS National Meeting, Boston, MA, United States, August
22-26, 2010.
22. Rochelle R. Arvizo; Priyabrata Mukherjee; Y. S. Prakash; Michael A. Thompson; Oscar R. Miranda; J. D. Robertson;
Vincent M. Rotello. Surface charge determines functional interactions between nanoparticles and cells. COLL-303.
CODEN: 69NAQG, 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010.
23. Zheng-Jiang Zhu; Partha Ghosh; Oscar R. Miranda; Richard W. Vachet; Vincent M. Rotello. Multiplexed screening of
the cellular uptake of gold nanoparticles using Laser Desorption/Ionization Mass Spectrometry. ANYL-204, CODEN:
69KXQ2, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008.
24. Chang-Cheng You; Oscar R. Miranda; Basar Gider; Partha S. Ghosh; Ik-Bum Kim; Uwe H. F. Bunz; Vincnet M.
Rotello. Detection and identification of proteins based on nanoparticle-fluorescent polymer arrays. ORGN-756,
CODEN: 69JAUY; 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007.
25. Megan Daley; Oscar R. Miranda; Norman R. Dollahon; Temer S. Ahmadi. Observation of a Critical Concentration of
L-Ascorbic Acid (Vitamin C) in the Photochemical Synthesis of Au Nanorods. MRM-445, CODEN: 69ICW3; 38th
Middle Atlantic Regional Meeting of the American Chemical Society, Hershey, PA, United States, June 4-7, 2006.
26. Charles C. Farraioli; Oscar R. Miranda; Norman R. Dollahon; Temer S. Ahmadi. Interplay of Temperature and UV-
Light in the Growth Process of Au-Nanorods. MRM-444, CODEN: 69ICW3; 38th Middle Atlantic Regional Meeting of
the American Chemical Society, Hershey, PA, United States, June 4-7, 2006.
References
• Dr. Noel M. Elman, Principal Research Scientist, Massachusetts Institute of Technology
Biomedical Devices and Translational Research Lab, Institute for Soldier Nanotechnologies (ISN)
500 Technology Square, NE47-525, Cambridge, MA 02139
Phone: (617) 324-6447, e-mail: nelman@mit.edu
• Prof. Jeffrey M. Karp, Associate Professor, Harvard Medical School
Harvard-MIT Health Sciences and Technology Division (HST)
Division of Biomedical Engineering, Department of Medicine
Brigham and Women's Hospital, Harvard Medical School
65 Landsdowne Street, PRB Room 313, Cambridge, MA 02139
Phone: (617) 817-9174, e-mail: jeffkarp.bwh@gmail.com
• Prof. Vincent M. Rotello, Charles A. Goessmann Professor, Department of Chemistry
University of Massachusetts-Amherst
379A LGRT Tower A, 710 North Pleasant Street, Amherst, MA 01003.
Phone: (413)-545-2058, e-mail: rotello@chem.umass.edu
• Prof. Temer S. Ahmadi, Associate Professor of Chemistry
Director, Chemistry Graduate Program
Villanova University
Mendel Hall Rm 214F, Chemistry Department
800 E. Lancaster Avenue, Villanova, PA 19085
Phone: (610) 519-7796, temershah.ahmadi@villanova.edu
• Prof. Uwe H. F. Bunz, Professor (W3)
Institut für Organische Chemie, Ruprecht-Karls-Universität Heidelberg
Im Neuenheimer Feld 270, Heidelberg 69120, Germany
Phone : +49 (622) 154-8401, e-mail : Uwe.Bunz@oci.uni-heidelberg.de