this ppt is about Ayurveda being tradition to trend with help of scientific evidence .

1. Dr. NIMISHA UPADHYAY
2ND Yr PG SCHOLAR
DEPT. OF DRAVYAGUNA VIJNANA 1

2. CONTENTS
Introduction
Definition
Roadmap
History
Pathways
Ayurvedic approach
Scientific approach
Hurdles
Recent development
Conclusion
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3. Derived from Greek words
oPharmakon - Drug
oLogos - Study
A drug is a moiety substance or chemical
entity which when consumed can intervene
at physical, physiological and
psychological levels.
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WHAT IS PHARMACOLOGY ?

4. ADR
Inefficiency
of drug
Race,
Topological
area
Drug
overdose
Consumption
of drugs
water,
Alcohol or
other
narcotics
Biologic
variability
Accessibility
Cost
effectiveness
LIMITATIONS OF PHARMACOLOGY
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5. • Reverse pharmacology is defined as science of
integrating documented experiments hits into leads that
are further developed into drug candidate or formulations
through more systematic and precisely designed
preclinical and clinical research.
• Salient feature of this approach is the combination of
knowledge learned from traditional or folk medicine and
the modern technology to provide better and safe leads.
REVERSE PHARMACOLOGY AND ITS APPROACH
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6. A representative of a compound series with sufficient
potential to progress to a full drug development
program
Lead is derived from hit, and has the desired activity
which is confirmed upon retesting.
KEY WORDS:
A drug target is a molecule in the body, associated with a particular
disease process and that could be addressed by a drug to produce a
desired therapeutic effect.
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8. DIFFERENTIATION
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10. HISTORY OF REVERSE
PHARMACOLOGY IN INDIA
• Sir Gananath Sen
 Father of Reverse pharmacology
 Laid the foundation of Reverse
pharmacology of medicinal plants
In 1993
demonstrated the
antihypertensive
and tranquilizing
effect of Rawolfia
serpentina.
Also observed
unique side effect
such as depression,
extra pyramidal
syndrome and
peptic ulcers
Sir Sen
Bose and
Kartik
Bose
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11. DOMAINS OF REVERSE PHARMACOLOGY
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Experimental Hits
and Targets
Exploratory
leads

12. DOCKING: MOLECULAR DOCKING,PATHWAY ANALYSIS
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13. RESPONSE MOLECULE
• A mechanism of action usually
includes mention of the specific
molecular targets to which the
drug binds, such as an enzyme
or receptor.
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• Receptor sites have specific
affinities for drugs based on
the chemical structure of the
drug, as well as the specific
action that occurs there.

14. EVIDENCE BASED MEDICINE FOR RP
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15. AYURVEDA AND REVERSE PHARMACOLOGY
ACTION AND
DRUG
KNOWN DRUGS
BEYOUND
ACTION
FOLKLORE
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16. 16
IDEAL AND
CHANGING
DECISION
AND
RESULT
AYURVEDA
IS
ETERNAL
TRANSLATIONAL AYURVEDA
Modified dosage forms
Blending of modern diagnosis with traditional use
HPTLC
Mass Spectrometry
High Throughput Screening (HTS)
Misleading Advertisement should not be
encouraged in the name of ayurveda.

17. SCIENTIFIC APPROACH
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19. Despite a vast potential and possibilities- very few success stories
Most of the work in the field has remained in clinics of
traditional practitioners or confined to academic research
laboratories
Improper experimental documentation
Lack of proper identity and implementation of
good laboratory practices
Cultural prejudice for
Alien Science.
HURDLES
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20. CUSTOMISED AND
PRECISION MEDICINE
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RECENT DEVELOPMENT

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The drug candidate is
an herbal beneficiated
extract of leaves of
Argemone mexicana
Under NMITLI, Lupin
Laboratories (India)
attempted development
of a single plant based
oral herbal formulations
through Reverse
Pharmacology
Novel mechanism of
action and effectively
modulates the cellar
function to psoriatic
lesion healing
improvement

24. Three main bottlenecks in drug development (Time, Money and Toxicity)
can easily addressed by reverse pharmacology.
It potentiates fast track drug development of newer, safer, and effective
drugs.
Normal drug developmental course “Laboratory to clinic” actually
becomes “Clinics to Laboratory” in RP.
These records are particularly valuable since effectively these medicines
have been tested for thousands years on people.
CONCLUSION
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26. • Many countries are becoming extremely aware of their traditional knowledge.
• Global pharmaceuticals industry is looking for innovative solutions to re-activate and re-
energize discovery pipeline.
• Adds a new life in existing global economic environment.
• It will be the interest of pharmaceutical companies, researchers and ultimately the global
community to respect the tradition build on their knowledge and experiential wisdom
ADVANTAGES AND LIMITATIONS
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27. REFERENCES
• Lagunin AA, Ivanov SM, Gloriozova TA, Pogodin PV, Filimonov DA, Kumar S, Goel
RK. Combined network pharmacology and virtual reverse pharmacology approaches for
identification of potential targets to treat vascular dementia. Sci Rep. 2020 Jan
14;10(1):257. doi: 10.1038/s41598-019-57199-9. PMID: 31937840; PMCID:
PMC6959222.
• Li L. Reverse Translational Pharmacology Research Is Driven by Big Data. CPT
Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):63-64. doi: 10.1002/psp4.12277. Epub
2018 Feb 19. PMID: 29457706; PMCID: PMC5824108.
• Saeidnia S, Gohari AR, Manayi A. Reverse Pharmacognosy and Reverse Pharmacology;
Two Closely Related Approaches for Drug Discovery Development. Curr Pharm
Biotechnol. 2016;17(11):1016-22. doi: 10.2174/1389201017666160709200208. PMID:
27396403.
• Miranda Furtado CL, Dos Santos Luciano MC, Silva Santos RD, Furtado GP, Moraes
MO, Pessoa C. Epidrugs: targeting epigenetic marks in cancer treatment. Epigenetics.
2019 Dec;14(12):1164-1176. doi: 10.1080/15592294.2019.1640546. Epub 2019 Jul 13.
PMID: 31282279; PMCID: PMC6791710.
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28. THANK YOU FOR
PATIENCE LISTENING
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