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WEIGHT LOSS AND BELLY FAT LOSS
Introduction
Weight isgenerally stable
Food intake = Energy expenditure
Coordinated control of the hypothalamus
“Feeding”center
“Satiety” center
Food intake
Availabilityof food
Attractiveness of food
Emotional factors
Introduction (Cont’d)
Energyexpenditure
Basal metabolism – 50%
Physical activity – 40 - 50%
Voluntary change in weight – not worrisome
Involuntary change in weight – may indicate
disease
Weight Gain
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Mechanisms of weight gain
Excess muscle – exercise
Excess fat – food intake > energy
expenditure
Excess water – fluid retention,
over hydration
Nature vs Narture
Genes
Fuel homeostasis
Energy expenditure
Hunger/satiety
Environment
Physical inactivity
Food
Sciocultural factors
Intrauterine
programming
Environment
Increased intake
Increased portionsizes
energy dense foods
High glycaemic index
foods
Softdrinks
Added sugar
Easyaccess to foods
Marketing
Decreased expenditure
Reduced exercise
Increased automation
Vehicles
Sedentary schools
Sedentaryworkplace
Elevators/Escalators
TV/Computer
Other causes of Weight Gain
Aging – slowed metabolism
Pregnancy
Endocrine & Other Medical Disorders
Cushing’s Syndrome
Hypothyroidism
Polycystic ovary syndrome
Hypogonadism
Some inherited diseases/genetic syndromes
Causes of Weight Gain (Cont’d)
 Drugs
 Corticosteroids
 Lithium
 Tranquilizers
 Antidepressants
 Emotional factors
 Anxiety
 Depression
 Guilt
 Lifestyle Factors
 Overeating
 Physical inactivity
Classification of BMI (in Kg/m2)
Underweight --BMI <18.5
Normal weight -- BMI ≥18.5 to 24.9
Overweight — BMI ≥25.0 to 29.9
Obesity — BMI ≥30
Obesity Class I — BMI of 30.0 to 34.9
Obesity Class II — BMI of 35.0 to 39.9
Obesity Class III — BMI ≥40
Prevalence of overweight, 2008
Source:WHO
Prevalence of CVD risk factors in A.A
Risk Factor
Prevalence (%)
Males Females
Overweight 20 38
Obese 2 10
Low level of Total
Physical Activity
17 31
High BP (> 140/90
mmHg)
32 29
Fikru et al., BMC Cardiovascular Disorders 2009, 9:39
Pear Shaped Fatness in Women
Excess Fat Deposited
Hips
Buttocks
Thighs
Apple Type Fatness in Males
Excess Fat Deposited
Abdomen (Beer
Bellies)
Health Risks of Obesity
Increased Morbidity
Type 2 Diabetes
Hypertension
Dyslipidemia
Coronary Heart Disease
Stroke
Health Risks of Obesity (Cont’d)
• Increased Morbidity
Cancer (endometrial, breast, colon)
Poor Qualityof Life
Psychosocial Dysfunction
Sleep Apnea
Osteoarthritis
Increased Mortality
Work up
History
Amountof gained weight
Duration of weightgain
Recent changes in diet orappetite
Rateof weight gain
Rapid weightgain – f luid retention
Work up (Cont’d)
History
Alcohol & Drugs Intake
Exercise Habit
Psychosocial Problems
Anyothersymptoms
Examination
Height, weight, BMI, waistcm
Neck size, BP, PR
Featuresof Insulin resistance
Goitre
Liveredge
Oedema
Laboratory tests
Glucosestudies, lipids, renal & liver function
Sleepstudies
Abdominal US, Echo
Secondarycauses
Geneticcause/suspicionof?
Waist Circumference
Males – 102 (94) cm
Females – 88 (80) cm
WEIGHT LOSS
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Introduction
Always ask aboutweightchange
Changeof 5% over 6 months is significant
Relative change is also important
Significantweight loss – markerof serious
illness
Persistence & periodicevaluation to identify
thecause - important
Mechanisms of weight loss
Increased energyexpenditure
Increased energy loss
Decreased food intake
Causes of weight loss
I. Involuntary with increased appetite
A. Increased energy
expenditure
Hyperthyroidism
Pheochromocytoma
Extensiveexercise
B. Increased energy loss
Diabetes Mellitus
Malabsorptionsyndromes
Chronicpancreatitis
Ulcerative colitis
Chrohn’sdisease
Celiac sprue
Causes of weight loss (Cont’d)
II. Involuntary with
decreased appetite
A. Medical disorders
Cancer
Infections: HIV, TB,
Endocarditis, lung
abscess, hepatitis,
chronic helminth
infection
Chronic illnesses
CHF, CLD, COPD, CKD
Endocrine diseases
Adrenal insufficiency
Hypercalcemia
GI Diseases
PUD
Strictures
Dysphagia
Diabetic gasteroparesis
Compressive mass
Infiltrating cancer
Hyperemesis gravidarum
B. Psychiatric Disorders
Depression
C. Chronic drug use
Alcohol
Metformin
Anti cancers
ART
Causes of weight loss (Cont’d)
III. Voluntary Weight Loss
• Diet and exercise
• Treatment of Obesity
• Anorexia Nervosa, Bulimia
Evaluation
• Ask About Appetite
• Food Intake
• Weight History
• Maximum Weight
• Usual Weight
• Current Weight
• Patients Underestimate/Overestimate
• Ask Family Members
Evaluation (cont’d)
• Voluntary or Involuntary
• Duration, rapidity & amount of Weight
Loss
• Nutritional Status
Evaluation (cont’d)
General Appearance
Vital Signs
HEENT :
Hair Changes
Pallor
Mouth changes
GLANDS :
Lymph Nodes
Thyroid
Evaluation (cont’d)
RESPIRATORY SYSTEM :
Cough
Dyspnea
Chest Findings
CVS :
Dyspnea
Orthopnea
Oedema
Cardiac Findings
Evaluation (cont’d)
• GIS : Vomiting – Gastric Outlet Obstruction
Diarrhea
Malabsorption
Chronic Liver Disease
Organomegaly
• GUS : Polyuria
Chronic Renal Failure
• CNS : Paraplegia
Malignancy
Motor Neurone Disease
DIAGNOSTIC WORK UP
FIRST PHASE TESTS – For Every Patient
• CBC/ESR
• Urinalysis
• Blood Chemistry Tests
• Fasting blood sugar
• Calcium
• Urea & Creatinine – Chronic renal failure
• Liver function tests – Chronic liver disease
• Electrolytes
FIRST PHASE TESTS – For Every Patient (Cont’d)
• TSH – Thyrotoxicosis
• HIV test
• Chest x- ray
• Stool for occult blood
SECOND PHASE TESTS
• CT scans – Abdomen, chest, brain
• Mammography
• Parathyroid hormone level (if calcium
level is elevated)
• Endoscopy
• Colonoscopy
SECOND PHASE TESTS (Cont’d)
• Blood Cultures
• 72 h stool fat
• Bone marrow biopsy
• Vitamin B12 level
• MRI of the spine
Conclusion
Gain & Loss in weightare importantclinical problems
Involuntarychange is a markerof serious underlying
disease
Alwaysask aboutappetite
Obesity is a seriousworld wide problemwith
increased morbidity & mortality
Persistenceand periodicevaluation is important to
reach at the underlying cause forweight loss
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  • 1. HIIT THE MIDDLE THE OFFICIAL WEBSITE WEIGHT LOSS AND BELLY FAT LOSS
  • 2. Introduction Weight isgenerally stable Food intake = Energy expenditure Coordinated control of the hypothalamus “Feeding”center “Satiety” center Food intake Availabilityof food Attractiveness of food Emotional factors
  • 3. Introduction (Cont’d) Energyexpenditure Basal metabolism – 50% Physical activity – 40 - 50% Voluntary change in weight – not worrisome Involuntary change in weight – may indicate disease
  • 5. Mechanisms of weight gain Excess muscle – exercise Excess fat – food intake > energy expenditure Excess water – fluid retention, over hydration
  • 6. Nature vs Narture Genes Fuel homeostasis Energy expenditure Hunger/satiety Environment Physical inactivity Food Sciocultural factors Intrauterine programming
  • 7. Environment Increased intake Increased portionsizes energy dense foods High glycaemic index foods Softdrinks Added sugar Easyaccess to foods Marketing Decreased expenditure Reduced exercise Increased automation Vehicles Sedentary schools Sedentaryworkplace Elevators/Escalators TV/Computer
  • 8. Other causes of Weight Gain Aging – slowed metabolism Pregnancy Endocrine & Other Medical Disorders Cushing’s Syndrome Hypothyroidism Polycystic ovary syndrome Hypogonadism Some inherited diseases/genetic syndromes
  • 9. Causes of Weight Gain (Cont’d)  Drugs  Corticosteroids  Lithium  Tranquilizers  Antidepressants  Emotional factors  Anxiety  Depression  Guilt
  • 10.  Lifestyle Factors  Overeating  Physical inactivity
  • 11. Classification of BMI (in Kg/m2) Underweight --BMI <18.5 Normal weight -- BMI ≥18.5 to 24.9 Overweight — BMI ≥25.0 to 29.9 Obesity — BMI ≥30 Obesity Class I — BMI of 30.0 to 34.9 Obesity Class II — BMI of 35.0 to 39.9 Obesity Class III — BMI ≥40
  • 12. Prevalence of overweight, 2008 Source:WHO
  • 13. Prevalence of CVD risk factors in A.A Risk Factor Prevalence (%) Males Females Overweight 20 38 Obese 2 10 Low level of Total Physical Activity 17 31 High BP (> 140/90 mmHg) 32 29 Fikru et al., BMC Cardiovascular Disorders 2009, 9:39
  • 14. Pear Shaped Fatness in Women Excess Fat Deposited Hips Buttocks Thighs
  • 15. Apple Type Fatness in Males Excess Fat Deposited Abdomen (Beer Bellies)
  • 16. Health Risks of Obesity Increased Morbidity Type 2 Diabetes Hypertension Dyslipidemia Coronary Heart Disease Stroke
  • 17. Health Risks of Obesity (Cont’d) • Increased Morbidity Cancer (endometrial, breast, colon) Poor Qualityof Life Psychosocial Dysfunction Sleep Apnea Osteoarthritis Increased Mortality
  • 18. Work up History Amountof gained weight Duration of weightgain Recent changes in diet orappetite Rateof weight gain Rapid weightgain – f luid retention
  • 19. Work up (Cont’d) History Alcohol & Drugs Intake Exercise Habit Psychosocial Problems Anyothersymptoms
  • 20. Examination Height, weight, BMI, waistcm Neck size, BP, PR Featuresof Insulin resistance Goitre Liveredge Oedema
  • 21. Laboratory tests Glucosestudies, lipids, renal & liver function Sleepstudies Abdominal US, Echo Secondarycauses Geneticcause/suspicionof?
  • 22.
  • 23.
  • 24. Waist Circumference Males – 102 (94) cm Females – 88 (80) cm
  • 25.
  • 27. Introduction Always ask aboutweightchange Changeof 5% over 6 months is significant Relative change is also important Significantweight loss – markerof serious illness Persistence & periodicevaluation to identify thecause - important
  • 28. Mechanisms of weight loss Increased energyexpenditure Increased energy loss Decreased food intake
  • 29. Causes of weight loss I. Involuntary with increased appetite A. Increased energy expenditure Hyperthyroidism Pheochromocytoma Extensiveexercise B. Increased energy loss Diabetes Mellitus Malabsorptionsyndromes Chronicpancreatitis Ulcerative colitis Chrohn’sdisease Celiac sprue
  • 30. Causes of weight loss (Cont’d) II. Involuntary with decreased appetite A. Medical disorders Cancer Infections: HIV, TB, Endocarditis, lung abscess, hepatitis, chronic helminth infection Chronic illnesses CHF, CLD, COPD, CKD Endocrine diseases Adrenal insufficiency Hypercalcemia GI Diseases PUD Strictures Dysphagia Diabetic gasteroparesis Compressive mass Infiltrating cancer Hyperemesis gravidarum B. Psychiatric Disorders Depression C. Chronic drug use Alcohol Metformin Anti cancers ART
  • 31. Causes of weight loss (Cont’d) III. Voluntary Weight Loss • Diet and exercise • Treatment of Obesity • Anorexia Nervosa, Bulimia
  • 32. Evaluation • Ask About Appetite • Food Intake • Weight History • Maximum Weight • Usual Weight • Current Weight • Patients Underestimate/Overestimate • Ask Family Members
  • 33. Evaluation (cont’d) • Voluntary or Involuntary • Duration, rapidity & amount of Weight Loss • Nutritional Status
  • 34. Evaluation (cont’d) General Appearance Vital Signs HEENT : Hair Changes Pallor Mouth changes GLANDS : Lymph Nodes Thyroid
  • 35. Evaluation (cont’d) RESPIRATORY SYSTEM : Cough Dyspnea Chest Findings CVS : Dyspnea Orthopnea Oedema Cardiac Findings
  • 36. Evaluation (cont’d) • GIS : Vomiting – Gastric Outlet Obstruction Diarrhea Malabsorption Chronic Liver Disease Organomegaly • GUS : Polyuria Chronic Renal Failure • CNS : Paraplegia Malignancy Motor Neurone Disease
  • 38. FIRST PHASE TESTS – For Every Patient • CBC/ESR • Urinalysis • Blood Chemistry Tests • Fasting blood sugar • Calcium • Urea & Creatinine – Chronic renal failure • Liver function tests – Chronic liver disease • Electrolytes
  • 39. FIRST PHASE TESTS – For Every Patient (Cont’d) • TSH – Thyrotoxicosis • HIV test • Chest x- ray • Stool for occult blood
  • 40. SECOND PHASE TESTS • CT scans – Abdomen, chest, brain • Mammography • Parathyroid hormone level (if calcium level is elevated) • Endoscopy • Colonoscopy
  • 41. SECOND PHASE TESTS (Cont’d) • Blood Cultures • 72 h stool fat • Bone marrow biopsy • Vitamin B12 level • MRI of the spine
  • 42. Conclusion Gain & Loss in weightare importantclinical problems Involuntarychange is a markerof serious underlying disease Alwaysask aboutappetite Obesity is a seriousworld wide problemwith increased morbidity & mortality Persistenceand periodicevaluation is important to reach at the underlying cause forweight loss
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