Understanding the role of contraction in the formation of scar is important for organ regeneration

1. COLLAGEN AND CANCELLATION
OF SKIN CONTRACTION in
WOUND HEALING
MUNIRA SHAHBUDDIN
KAUFMAN TEACHING CERTIFICATE PROGRAM
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
9 APRIL 2018

2. COLLAGEN
Is the most ubiquitous
and stable protein in the
animal kingdom that exist
since 12 million years
ago.
Widely used in cosmetic
applications, also in
tissue engineering and
regeneration.
https://biomaterials.ca/#!/abstracts/view/113505

3. WOUND
HEALING
Mechanism of closure as
an end point after injury.
TWO TYPE OF WOUND
HEALING
- Regeneration
- Repair = contraction
and scar formation

4. Orgill, 1983.

5. REGENERATION
Jackson. Stem Cell Research & Therapy2017

6. CONTRACTION
AND SCAR
FORMATION
Wound closure differentiated
into : green area, contraction,
purple area, reepithelization and
red is the open wound.
http://cica-biomedical.com/index_files/preclinicalresearchwoundhealing.htm

7. NORMAL SKIN VS
SCAR TISSUE
Scar tissue is inferior to normal
skin, cosmetically and
physiologically.
This is thought due to the
formation of collagen bundle
forming during the wound healing
process.
http://cica-biomedical.com/index_files/preclinicalresearchwoundhealing.htm

8. CANCELLATION
OF SKIN
CONTRACTION
Three structural
features of
collagen scaffolds
that are required
for regenerative
activity
I.V. Yannas. 2013
1. Pore size
2. Degradation rate
3. Surface chemistry

9. I.V. Yannas. 2013
UNDERSTANDING THE ROLE OF
MYOFIBROBLASTS IN CONTRACTION

10. Cell-cell cluster inside the MFB
capsule in 400 um average pore size
Cell-cell cluster inside the MFB
capsule in 40 um average pore size
I.V. Yannas. 2013