Hodgkin's and non Hodgkin's lymphoma

1. HAEMATOLOGICAL
DISORDERS.
KMTC.

2. Review of anatomy and physiology of the
cell.
 Hematopoiesis?
 Constituents of blood?
 Classification of blood cells?
 What is the process of RBC formation?
 What are the functions of blood?

3. The cells

4. Cont.
 Hematopoiesis- process by which the cellular components of the blood are formed.
 Blood is composed of hematocrit and plasma:
 Hematocrit (45%): composed of erythrocytes and it is the densest component of
blood.

5. Cont.
 Plasma (55%): composed of water (primary component), protein (e.g. albumin,
immunoglobulins, fibrinogen) and non-protein components (e.g. vitamins, lipids,
hormones).
 Buffy coat (<1%): contains leucocytes and platelets.

6. Qn 1.
1. What is the difference between plasma and serum?

7. Qn 2
2. Which of one of the following type of cells does not
have nucleus and organelles?
a. Basophiles
b. Leukocytes
c. Erythrocytes.
d. Thrombocytes.

8. Cont.

9. Classification.
 All of the cells found in the blood come from bone marrow. They begin their life as
stem cells, and they mature into three main types of cells— RBCs, WBCs, and
platelets.

10. RBCs
 Concave shaped cells.
 carry oxygen towards the tissues from the lungs. It does this by binding oxygen to
hemoglobin.
 carry carbon dioxide away from the tissues and towards the lungs. ...
 red blood cells' functions also include determining a person's blood type.

11. Cont.

12. (B) WBC
 There are five types of WBC.
 1. granulocytes:
 Neutrophils - (PMNL).
 Eosinophils
 Basophils
NB. i.e. have granules in their cytoplasm.
 2. Non – granulocytes:
 Lymphocytes
 Monocytes.

13. Cont.

14. Cont.

15. Platelets.
 They are derived from megakaryocytes in the BM. These cells are necessary for clotting
of blood.
 They are discoid in shape.

16. Cont.
 Three types are present in the cytoplasm
a) Alpha granules- Contain fibrinogen and Von Will brand Factor
b) Dense (Delta) granules – Store adenosine Diphosphate (ADP) and 5-
hydroxytryptamine (5-HT, serotonin)
c) Lysosomes contain acid hydrolases

17. End of the general over view of the A&P
of the blood cells.
 Please revise it in details.