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Management of Asthma
DR. M. ZAID UR REHMAN
H.O. MU-4
DHQ HOSPITAL FAISALABAD.
Aims of treatment
 Abolish symptoms
 Restore normal or best possible lung function
 Reduce the risk of severe attacks
 Minimize absence from school or employment
Investigations
 Lung function tests
Peak Expiratory Flow Rate (PEFR)
Spirometry
 Blood & Sputum tests ( Increased Eosinophils)
 Trial of Corticosteroids
 Chest X-ray
 Skin-prick tests
Control of extrinsic factors
 Where specific allergen triggers are identified, these
should be avoided if possible.
 Replace Carpets with floorboards
 Use of Mite impermeable bedding
 Avoidance of Smoking
 Avoidance of NSAIDs
Pharmacological Treatment
 Stepwise Approach to management of Asthma
 STEP 1 : Occasional Symptoms :-
 Symptoms less than once per week for 3 months and fewer than two nocturnal
episodes per month
 Use of Short Acting Beta-2 Agonists
 Inhaler Salbutamol ( Ventolin) : 1-4 puffs as and when required.
 STEP 2 : Daily Symptoms :
 Regular Inhaled Preventer Therapy
 Inhaled low-dose Corticosteroids
 Inhaler Bekson (2-4 puffs 2-4 times daily)
 Inhaler Ventolin ( 1-4 puffs as and when required)
 STEP 3 : Severe Symptoms
 Add-on Therapy
 Inhaled Corticosteroids + LABA
 Inhaler Salmicort ( Fluticasone + Salmetrol) ( 2 Puffs BD)
 Inhaler Ventolin ( 1-4 puffs as and when required)
 Tab Myteka ( Montelukast ) 10 mg at bedtime
 STEP 4 : Severe Symptoms Uncontrolled
 High-dose ICS + Regular Bronchodilators
 Inhaler Salmicort ( 2-4 puffs BD)
or
 Inhaler Foster ( Formoterol + Beclomethasone) 2-4 puffs BD
 Inhaler Ventolin ( 1-4 puffs as and when required)
 Cap Respro ( Theophylline) 200, 300 mg BD
 Tab Myteka ( Montelukast ) 10 mg at bedtime
 STEP 5: Severe Symptoms Deteriorating
 Regular Oral Corticosteroids
 Tab Deltacortil ( Prednisolone) ( 5mg ) ( 3 tab TDS)
 Side effects of Steroids :
1) Osteoporosis 2) Oral Candidiasis
3) Hoarseness
 Steroid sparing Drugs : Methotrexate, Ciclosporin
Management of Acute Severe Asthma
Tyoical Features :
1. Inability to complete a sentence in one breath
2. RR > 25 breaths/min
3. HR > 110 bpm
4. PEFR < 50 %
Life threatnening features :
 Silent chest, Cyanosis
 Confusion , Coma
 Bradycardia , Hypotension
 PEFR < 30%
 P O2 < 60 mmHg , P CO2 > 45 mmHg
Treatment
 Oxygen
 High-dose Inhaled Bronchodilators ( Neb e Ventolin )
 Nebulize with Ipratropium Bromide ( Atem )
 IV Hydrocortisone ( Solucortif )
If patient dosen’t respond, add
 Inj Aminophylline
 Inj Magnesium Sulphate
 Tab Augmentin ( if there is evidence of infection)
If there is still no improvement then Urgent Transfer to ICU.
If patient responding then
Continue Oxygen
Replace Inj Solucortif with Deltacortil ( 3 tablets TDS)
Continue Nebulization with Ventolin & Atem at 4-6 hrs interval.
Assess the patient with following
 ABGs
 Chest X-ray to rule out pneumothorax
 Regular monitoring of Oxygen saturation & PEFR
Any Question ???
Asthma

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Asthma

  • 1.
  • 2. Management of Asthma DR. M. ZAID UR REHMAN H.O. MU-4 DHQ HOSPITAL FAISALABAD.
  • 3. Aims of treatment  Abolish symptoms  Restore normal or best possible lung function  Reduce the risk of severe attacks  Minimize absence from school or employment
  • 4. Investigations  Lung function tests Peak Expiratory Flow Rate (PEFR) Spirometry  Blood & Sputum tests ( Increased Eosinophils)  Trial of Corticosteroids  Chest X-ray  Skin-prick tests
  • 5. Control of extrinsic factors  Where specific allergen triggers are identified, these should be avoided if possible.  Replace Carpets with floorboards  Use of Mite impermeable bedding  Avoidance of Smoking  Avoidance of NSAIDs
  • 6. Pharmacological Treatment  Stepwise Approach to management of Asthma  STEP 1 : Occasional Symptoms :-  Symptoms less than once per week for 3 months and fewer than two nocturnal episodes per month  Use of Short Acting Beta-2 Agonists  Inhaler Salbutamol ( Ventolin) : 1-4 puffs as and when required.
  • 7.  STEP 2 : Daily Symptoms :  Regular Inhaled Preventer Therapy  Inhaled low-dose Corticosteroids  Inhaler Bekson (2-4 puffs 2-4 times daily)  Inhaler Ventolin ( 1-4 puffs as and when required)
  • 8.  STEP 3 : Severe Symptoms  Add-on Therapy  Inhaled Corticosteroids + LABA  Inhaler Salmicort ( Fluticasone + Salmetrol) ( 2 Puffs BD)  Inhaler Ventolin ( 1-4 puffs as and when required)  Tab Myteka ( Montelukast ) 10 mg at bedtime
  • 9.  STEP 4 : Severe Symptoms Uncontrolled  High-dose ICS + Regular Bronchodilators  Inhaler Salmicort ( 2-4 puffs BD) or  Inhaler Foster ( Formoterol + Beclomethasone) 2-4 puffs BD  Inhaler Ventolin ( 1-4 puffs as and when required)  Cap Respro ( Theophylline) 200, 300 mg BD  Tab Myteka ( Montelukast ) 10 mg at bedtime
  • 10.  STEP 5: Severe Symptoms Deteriorating  Regular Oral Corticosteroids  Tab Deltacortil ( Prednisolone) ( 5mg ) ( 3 tab TDS)  Side effects of Steroids : 1) Osteoporosis 2) Oral Candidiasis 3) Hoarseness  Steroid sparing Drugs : Methotrexate, Ciclosporin
  • 11. Management of Acute Severe Asthma Tyoical Features : 1. Inability to complete a sentence in one breath 2. RR > 25 breaths/min 3. HR > 110 bpm 4. PEFR < 50 % Life threatnening features :  Silent chest, Cyanosis  Confusion , Coma  Bradycardia , Hypotension  PEFR < 30%  P O2 < 60 mmHg , P CO2 > 45 mmHg
  • 12. Treatment  Oxygen  High-dose Inhaled Bronchodilators ( Neb e Ventolin )  Nebulize with Ipratropium Bromide ( Atem )  IV Hydrocortisone ( Solucortif ) If patient dosen’t respond, add  Inj Aminophylline  Inj Magnesium Sulphate  Tab Augmentin ( if there is evidence of infection)
  • 13. If there is still no improvement then Urgent Transfer to ICU. If patient responding then Continue Oxygen Replace Inj Solucortif with Deltacortil ( 3 tablets TDS) Continue Nebulization with Ventolin & Atem at 4-6 hrs interval.
  • 14. Assess the patient with following  ABGs  Chest X-ray to rule out pneumothorax  Regular monitoring of Oxygen saturation & PEFR