Protein and Peptide drug delivery system are the Novel drug Delivery System

1. Introduction to Protein And Peptide Drug
delivery system
PRESENTED BY:
Megha
Assistant Professor

3. INTRODUCTION :-
Protein and Peptide drug delivery system are the Novel drug Delivery System.
Proteins and peptides are the most abundant components of biological cells. They
exist functioning such as enzymes, hormones, structural element and
immunoglobulin. It is also important take part in Several Metabolic Process,
Immunogenic Defense as well as its take part in several Biological activities.
Protein:-
Proteins are the high molecular weight mixed polymer of Alpha amino acids joined
together the Peptide Linkages. In Protein mainly contain Carbon, Nitrogen, Oxygen
and Sulphur Molecule. Protein are the compounds having linear chain amino acids
are held together by the peptide Linkage.

4. Structure Of protein
Protein
Primary
protein
Secondary
protein
Tertiary
protein
Quaternary
protein
Primary structure
It is simply the sequence of amino acids in a polypeptide chain.
For example, The hormone insulin has two polypeptide chains, A and B,
shown in diagram below. Each chain has its own set of amino acids,
assembled in a particular order. For instance, the sequence of the A chain
starts with glycine at the N-terminus and ends with asparagine at the C-
terminus, and is different from the sequence of the B chain.

5. Secondary structure
 It refers to local folded structures that form within a polypeptide due to
interactions between atoms of the backbone.
α helix β pleated sheet

6. Tertiary structure
 The three-dimensional structure of a polypeptide. The tertiary structure is
primarily due to interactions between the R groups of the amino acids that
make up the protein

7. Fig3. Tertiary
structure
Quaternary structure
 Some proteins are made up of multiple polypeptide chains, also known as
subunits. When these subunits come together, they give the protein
its quaternary structure.
Ionic bond
Polypeptide
backbone
Hydrogen
bond
Disulfide
linkage
Hydrophobic
interaction

8. Primary structure of
protein
Secondary structure
of protein
Tertiary structure of
protein
Quaternary
structure of protein

9. Need For Protein And Peptide Drug Delivery:-
 Role of proteins and peptides in the biological system is immense . Lack of a
specific protein due to the disease state of the secreting organ can disrupt the
normal functioning of the biological system, which can at particular times, prove to
be fatal.
 eg. Diabetes mellitus is the result of absolute or relative deficiency of insulin in the
body.
 Insulin is a protein secreted from the pancreas and lack of insulin leads to
eventual death if insulin is not supplied by an exogenous source.
Biotechnology played a key role in the development of protein/ peptide drugs.
In many ways proteins are ideal drugs because they carry out essentially all biologic
processes and reactions.

10. Thank You