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24.antiplatelet drugs
1.
Antiplatelet drugs Interfere with
platelet function
2.
Classification 1. TXA2 synthesis
inhibitor: Aspirin 2. Others: Dipyridamole, clopidogrel, ticlopidine abciximab
3.
ASPIRIN Low dose
aspirin (75-150 mg/day)- selectively produce antiplatelet activity Irreversibly inhibits thromboxane synthase Reduces TXA2 production antiplatelet activity
4.
Mechanism of action Membrane
phospholipids ↓ Arachidonic acid ↓ cyclic endoperoxides ↓ Thromboxane synthase TXA2 (platelet aggregation) Aspirin Inhibits
5.
Therapeutic uses 1. Myocardial
infarction (MI) 2. Prevent MI in high risk patients 3. Reduce incidence of stroke in high risk patients
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