5. Uses of statinsUses of statins
Familial hypercholestrolemiaFamilial hypercholestrolemia
Familial combined hyperlipidemiaFamilial combined hyperlipidemia
6. EZETIMIBEEZETIMIBE
Decreases GI Uptake of cholesterol
Synergistic action with statin
Statin decreased synthesis of
cholesterol in liver
+
Ezetimibe absorption from intestine
8. Fibric Acid DerivativesFibric Acid Derivatives
Gemfibrozil and FenofibrateGemfibrozil and Fenofibrate
Lower triglycerides and raise HDLLower triglycerides and raise HDL
9. Fibric Acid DerivativesFibric Acid Derivatives
Side EffectsSide Effects
Rash, GI symptoms,Rash, GI symptoms, myopathy,myopathy, highhigh
aminotransferaseaminotransferase
10. Sites of Action for HypolipidemicsSites of Action for Hypolipidemics