Oxidative Stress and ROS impact health, impair immune function, and therefor antioxidant therapy is a viable adjunctive treatment in HHIV/AIDS

1. 245441
Therapeutic nutritional supplementation for HIV patients:
Assertive nutritional support improves HIV/AIDS outcomes by mediating oxidative stress and ROS
Manley R. Finch, PhD(c), MPH1, Gary Samuelson, PhD2.
1HIV Nutrition Network, NPO; 2 Nutraceutical Innovation Alliance
Abstract Background Continued Critical Pathways for ROS Elimination and Antioxidant
Antioxidant Supplementation is Critical for
Micronutrient supplements have been proposed as low-cost immuno-modulating Protection of Cellular Structure
interventions that may improve the quality of life of HIV/ AIDS patients, improve
Pro-inflammatory and oxidative stress related CVD is now one of the leading Positive HIV/AIDS Outcomes
causes of HIV/AIDS related deaths in those virally suppressed on HAART7.
immune function, and reduce the effects of HIV/AIDS and HARRT related • Selenium supplementation has been shown to increase CD4 counts and
Recent literature suggests that micronutrient and antioxidant restore glutathione levels in HIV/AIDS patients32.
oxidative stress. Recent literature suggests that those living with HIV/AIDS are at supplementation in HIV/AIDS patients may reverse these effects, increase
risk of micronutrient and antioxidant deficiencies, higher concentrations of • Selenium has been implicated in HIV viral seleno-protein pathways36.
CD4 T-cell counts, and increase other markers of immune function10,11,13. • Zinc has been shown to improve HIV/AIDS outcomes10,11,13.
circulating and cellular reactive oxidative species (ROS), and therefore at risk of
Supplementation is low cost, poses no additional side effect risk, may • General vitamin & antioxidant supplementation improves HIV/AIDS
complications mediated by oxidative stress.
ameliorate the oxidative stress created by HAART and HIV, and bestow outcomes, increase CD4 counts, lower comorbidity 33, 34,35.
There may be a relationship between suboptimal micronutrient status and increased immune function11,13.
multivitamin use and quality of life in HIV patients. This has been noted in both IT IS IMPERATIVE THAT ASSERTIVE ANTIOXIDANT AND
prospective controlled studies and observational studies. Multivitamin and micro MULTIVITAMIN THERAPY IS INITIATED AND SUSTAINED
nutrient supplementation may significantly reduce oxidative stress and the OXIDATIVE STRESS PATHWAY IN U.S. AND GLOBAL HIV/AIDS PROGRAMS
concomitant secondary and tertiary co-morbidities associated with HIV disease. Protective enzyme synthesis enables Reduction-oxidation (Redox) Dangerous excess of free radicals can be
Benefits may include significant reductions in reported fatigue, rash, diarrhea, protein reduction-oxidation equilibrium optimizes cell efficiency neutralized by Reduced Antioxidants
weight loss, upper respiratory tract infections, and morbidity. Additional benefits
may include increased CD4 counts, glutathione levels, mitochondrial function,
and other markers of immune function. Micronutrients may protect the integrity Immuno-Supportive Supplements Help Balance Critical
of oral and gastrointestinal epithelia and enhance local and systemic immunity.
These nutrients may enhance immune function, as measured by the levels of Pathways That Regulate Cellular Protection and Repair
CD4-T cells, glutathione, and anti-inflammatory cytokines.
ROS
Anti-oxidant Damaged
The economic burden of HIV/AIDS infection is considerable, especially in Healthy Cell Shield Cell
underdeveloped nations and socioeconomically challenged populations. Reduced
Species
Malnutrition and micronutrient deficiencies mediate the progression of HIV/AIDS Nucleus Nucleus
and contribute to increased co-morbidities. Vitamin supplementation, including DNA DNA
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A Redox imbalance results in oxidative stress (excess 7.
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of ROS and Oxidative Stress related HIV/AIDS various agents. The toxicity is expected to be minimal,
morbidities such as cardiotoxicity, CVD, dyslipidemia, neurodegenerative GP120 attachment points (b) shown
progression,12,13,15,16,17,18,24. in the case of silver particles, they have been used for
without nanoparticle exposure
disorders, dementia, endothelial dysfunction and elevated inflammatory over 50 years with no critical toxicity.
states4,5,6,7,8,9,10,12.