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Xavier Paqueron MD, PhD
Clinical Centre, Angoulême, France
Ultrasound-guided regional anesthesia. :
What do ultrasound bring to regional anesthesia ?
xavier.paqueron@orange.fr
Close to Bordeaux and Cognac
Where is , France ?
Close to
Cognac
Close
to
Bordeaux
Where is , France ?
Private 300 beds Hospital
My Institution : The Clinical Centre
Ambulatory	Care	Unit	
Surgery	
•  Orthopedic	
•  Hand	
•  Urologic	
•  Vascular	
•  Abdominal	
•  Gynecologic	
•  Breast	
•  OPH	
•  ENT	
Obstetrics	
Pain	Clinic	
Medicine	
•  Oncology	
•  Internal	medicine	
•  Cardiology	
•  Pneumology	
www.centre-clinical.fr/	
Regional	anesthesia	room
PACU
Current place of regional anesthesia
① Postoperative pain control
② Improved postoperative recovery
③ Alternative to GA
④ Ambulatory surgery
⑤ PONV
1
RA superior to morphine during the 2 first postoperative days
0
2
4
6
8
10
24 Hrs 48 Hrs
catheter
opiates
0
1
2
3
4
24 Hrs 48 Hrs 72 Hrs
catheter
opiates Mean VASMax VAS
Continuous blocks = the reference
Recovery - Rehabilitation
Alternative to GA
In ambulatory
surgery
Post Operative Nausea & Vomiting
Cost/effectiveness
Of US-guidance
Evidence-based & ultrasound guidance
① Success rate
② Comfort
③ Other benefits
2
Evidence-based
Improved		
Success	
Rate	
0	
25	
50	
75	
100	
Complete	sensory	block	
at	30	min	
Successful	surgical	
anesthesia	
Percentatge	(%)	
NS	 US	 US&NS	
0	
5	
10	
15	
Procedure	Bme	(min)	
Time	(minutes)	
NS	 US	 US&NS	
*
* *
P=	0.07		
* P<	0.05
Success
Rate
Conversion
to
GA or spinal
A Meta-analysis
(Abrahams 2009)
Onset time of block
A Meta-analysis
(Abrahams 2009)
Casati 2007, Orebaugh 2007
Reduction of number of needle trajectories with USGRA
Perceived pain is less frequent
20 % with USGRA vs 48 % nerve stimulation
How USGRA does improve safety ?
① Control of needle tip
② Diagnose early
•  intravascular
③ Reduce toxicity
•  Reduce volumes
④ Diagnose early
•  Intraneural
3
Always believe that what you think is the needle tip may not be it
Control of needle tip - Whatever the approach
Always consider you may not see the needle tip
Move	the	probe	to	see	the	needle
		
Tissue	movements	/	needle	
AssociaIon	with	nerve	sImulaIon	
HydrolocaIon	
THE Obsession - Know where the needle tip is
Diagnose Early
Intravascular injection
Look here !
Systemic toxicity
Case reports
2007	
2008	
2008	
2013	
2014
Systemic toxicity
Number of blocks = 5436
•  US = 2146!
•  PNS = 3290!
Adverse events = 8
•  Seizures = 5 (PNS)!
•  Nerve injury = 3 (PNS)!
2009	
Adverve event with US = 0
Systemic toxicity
2013
Improve safety
Reduce volumes
Axillary	block	with		
1	ml	per	nerve	!	
0,7	ml	to	block	the	ulnar	
nerve	at	the	wrist
UltraSound-Guided Regional Anesthesia
doesn’t avoid nerve damage
Two recent case reports of persistent nerve damage with
•  No pain
•  No paresthesia
•  at least one followed an intraneural injection
Nerve damage
Intraneural injection
Ultrasound
Contribution
The anesthetist is no longer blind
•  Accuracy ~ 1 mm with high frequency probes
Visualisation of one third of all fascicles
Silvestri et al. Radiology 1995
•  Fascicles size ~ 0.25 - 0.5 mm
Ultrasound
Contribution
Contact between nerve and needle
•  motor response ≤ 0.5 mA: 74.5%
•  paresthesia: 38.2%
Perlas RAPM 2006
Stimulating needle can
touch a nerve with no
motor response !
Bigeleisen 2006
Frequent intraneural /
subepineural injection of
local anesthetics
… under US guidance
Nerve swelling = 70%
Ultrasound
Contribution
Bigeleisen 2009
Ultrasound-guided supraclavicular block
and nerve stimulation
1. Needle-nerve contact
Ä minimal stimulating current
2. Needle advanced intraneurally
Ä minimal stimulating current
Ultrasound
Contribution
Ultrasound
Contribution
DM: Diabetis Mellitus
Stimulating thresholds
≤ 0.2 mA never observed outside the trunk
> 0.5 mA within the trunk : 10% of patients
Better understanding of the limits of nerve stimulation
•  Intraneural injection is (very) frequent
•  MIS ≥ 0.5 mA : No guarantee of being extraneural
•  Contact needle-nerve without motor response = frequent
•  Subepineural needle placement without motor response = frequent
•  Intraneural injection without pain or paresthesia
… and without nerve damage
Ultrasound
Contribution
Sala-Blanch 2009
Needles through human
sciatic nerve
Intraneural injection & nerve damage
More likely: transverse the nerve between
the fascicles rather than through them
A- EXTRA NEURAL
Extraneural connective tissue
B- EPINEURAL
Connective tissue between fascicles
C- INTRA-FASCICULAR
Into (between) nerve fibres
I choose where I inject…
Ultrasound contribution
•  probability of subepinerium location of needle tip
•  If motor response at an intensity < 0.2 mA
•  Use a test dose (1 ml) = hydrolocation
•  If you see
•  Swelling = STOP all further injection (subepineural)
•  Nothing when you inject = iv injection or needle tip not in US beam
•  If you stop the injection
•  In case of swelling … unknown risk!
•  When nothing appears = risk well known (intravascular)
Nerve swelling after 1 ml
Motor response < 0.2 mA
Ultrasound contribution
needle tip is
Subepineural
Learnig US-guidance
① Learning curve
② Rapid improvment
③ But mistakes persist …
4
Learnig US-guidance
Learning curve
0	
2	
4	
6	
8	
10	
Trial	
1	
Trial	
2	
Trial	
3	
Trial	
4	
Trial	
5	
Trial	
6	
Composite	Score	of	
Accuracy	
0	
50	
100	
150	
200	
250	
Trial	
1	
Trial	
2	
Trial	
3	
Trial	
4	
Trial	
5	
Trial	
6	
Speed	of	performance	
(sec)	
Performance	Ime	
reduced	by	48%
Improvement	of	
Accuracy	by	59%
Rapid	improvment	of	success
Learnig US-guidance
Mistakes persist
Video	analyses	
6	anesthesia	residents		
Novices	in	USGRA	
Two	most	common	errors	
•  Failure	to	visualize	needle	before	
advancement	
•  UnintenBonal	probe	movement
Failure	to	visualize	the	needle	…
Conclusion
Improve efficiency with Ultrasound
Cheaper
Compared with
Nerve stimulation
Improved success rate
•  Less time to perform blocks
•  Reduction of volumes
•  Improve patient comfort
Easy learning
•  Rapid learning curve
ü  See needle tip
ü  Unintentional probe
movements
Improve safety with Ultrasound
Decrease LAST
•  Monitor needle tip
•  Reduce volumes
•  Detect intravascular
injection early
Decrease Nerve damage
•  Don’t inject intraneurally = No nerve swelling
•  Association with nerve stimulation
•  Monitor injection pressures
•  Use blunt tip needle
•  Monitor needle tip
Thank You

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