1. LUCIA TAPIA Ph.D. - PUBLICATIONS
Munsie LN, Milnerwood AJ,Seibler P,Beccano-Kelly DA,Tatarnikov I, Khinda J, Volta M,
Kadgien C, Cao LP,Tapia L, Klein C, Farrer MJ. Retromer-dependent neurotransmitter receptor
trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.Hum
Mol Genet. 2015 Mar 15;24(6):1691-703.
Beccano-Kelly DA,Volta M, Munsie LN,Paschall SA, Tatarnikov I, Co K, Chou P,Cao LP,
Bergeron S, Mitchell E, Han H,Melrose HL, Tapia L, Raymond LA, Farrer MJ, Milnerwood AJ.
LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone,
postsynaptic signal transduction, motor activity and memory. Hum Mol Genet. 2015 Mar
1;24(5):1336-49.
Beccano-Kelly DA,Kuhlmann N, Tatarnikov I, Volta M, Munsie LN, Chou P,Cao LP,Han H, Tapia
L, Farrer MJ, Milnerwood AJ. Synaptic function is modulated by LRRK2 and glutamate release
is increased in cortical neurons ofG2019S LRRK2 knock-in mice. Front Cell Neurosci. 2014 Sep
26;8:301. doi: 10.3389/fncel.2014.00301. eCollection 2014.
Vilariño-Güell C, Rajput A, Milnerwood AJ, Shah B, Szu-Tu C, Trinh J, Yu I, Encarnacion M,
Munsie LN, Tapia L, Gustavsson EK, Chou P,Tatarnikov I, Evans DM, Pishotta FT, Volta M,
Beccano-Kelly D, Thompson C, Lin MK, Sherman HE, Han HJ, Guenther BL, Wasserman WW,
Bernard V, Ross CJ, Appel-Cresswell S, Stoessl AJ, Robinson CA,Dickson DW, Ross OA,Wszolek
ZK, Aasly JO,Wu RM, Hentati F, Gibson RA, McPherson PS,Girard M, Rajput M, Rajput AH,
Farrer MJ. DNAJC13 mutations in Parkinson disease. Hum Mol Genet. 2014 Apr 1;23(7):1794-
801.
Chartier-Harlin MC, DachselJC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus
J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot
C, Kreisler A, Ross OA, Nishioka K, Soto-Ortolaza AI, Cobb SA, Melrose HL, Behrouz B, Keeling
BH, Bacon JA, HentatiE, Williams L, Yanagiya A, Sonenberg N, Lockhart PJ,Zubair AC, Uitti RJ,
Aasly JO, Krygowska-Wajs A, Opala G, Wszolek ZK, Frigerio R, Maraganore DM, Gosal D, Lynch
T, Hutchinson M, Bentivoglio AR, Valente EM, Nichols WC, Pankratz N, Foroud T, Gibson RA,
Hentati F, Dickson DW, Destée A,Farrer MJ. Translation initiator EIF4G1mutations in familial
Parkinson disease. Am J Hum Genet. 2011 Sep 9;89(3):398-406.
Tapia L, Milnerwood A, Guo A, Mills F, Yoshida E, Vasuta C, Mackenzie IR, Raymond L, Cynader
M, Jia W, Bamji SX. Progranulin deficiency decreases grossneuronal connectivity but enhances
transmission at individual synapses. J Neurosci. 2011 Aug 3;31(31):11126-32.
Guo A, Tapia L, Bamji SX, Cynader MS, Jia W. Progranulin deficiency leads to enhanced cell
vulnerability and TDP-43 translocation in primary neuronal cultures. Brain Res. 2010 Dec
17;1366:1-8.
O'Connor TP,Cockburn K, Wang W, Tapia L, Currie E, Bamji SX. Semaphorin 5B mediates
synapse elimination in hippocampal neurons. NeuralDev. 2009 May 23;4:18.
Krivosheya D, Tapia L, Levinson JN, Huang K, Kang Y, Hines R, Ting AK, Craig AM, Mei L, Bamji
SX, El-Husseini A. ErbB4-neuregulin signaling modulates synapse development and dendritic
arborization through distinct mechanisms. J Biol Chem. 2008 Nov 21;283(47):32944-56.

2. Tapia L, Suazo M, Hödar C, Cambiazo V, González M. Copper exposure modifies the content and
distribution of trace metals in mammalian cultured cells.Biometals. 2003 Mar;16(1):169-74.
Tapia L, González-Agüero M, Cisternas MF, Suazo M, Cambiazo V, Uauy R, González M.
Metallothionein is crucial for safe intracellular copper storage and cell survival at normal and
supra-physiological exposure levels. Biochem J. 2004 Mar 1;378(Pt 2):617-24.
Arredondo M, Cambiazo V, Tapia L, González-Agüero M, Núñez MT, Uauy R, González M. Copper
overload affects copper and iron metabolism in Hep-G2 cells. Am J Physiol Gastrointest Liver
Physiol. 2004 Jul;287(1):G27-32.
Cross D, Tapia L, Garrido J, Maccioni RB. Tau-like proteins associated with centrosomes in
cultured cells.Exp Cell Res. 1996 Dec 15;229(2):378-87.
Maccioni, R.B.,Tapia, L., and Cambiazo, V. (1995). Functional organization oftau proteins
during neuronal differentiation and development. Braz. J. of Med. Biol. Res. 28 (8): 827-841.
Bronfman, F.C.,Soto, C.,Tapia, L., Tapia, V., and Inestrosa N.C. (1996). Extracellular matrix
regulates the amount of β-amyloid precursor protein and its amyloidogenic fragment. J. Cell
Phys. 166: 360-369.