Microba Partnerships Slides

1. 1
Dr Kasra Sabermanesh
Regional Partnerships Manager

2. 2
Driven to improve patient care
Measure. Predict. Treat.
Microba is a leading microbial genomics company specializing
in predictive diagnostics & therapeutics with a mission to
advance identification of disease and discover new treatments
to improve patient outcomes, and reduce
overall cost of health care.

3. 3
There is unequivocal
evidence demonstrating
the gut microbiome acts
systemically & is a critical
factor in health & disease
Gut health matters
Valdes, A., Walter, J., Segal, E., and Spector, T (2018). Role of the gut microbiota in nutrition and health. BMJ 2018;361:k21791​

4. 4
A change in perception

5. 5
▪ Increasing awareness of
gut microbiome importance &
links to health
▪ Increasing proactive well
market segment
▪ Increasing prevalence of
consumers with unresolved
health issues seeking solutions
Microba is experiencing 28% YOY growth in microbiome testing based on strong drivers from both patients and practitioners.
▪ Patients asking their practitioner
about gut microbiome testing
▪ Practitioners are seeking education
and support
▪ Practitioners are seeking evidence
based, actionable gut microbiome
testing
▪ Practitioners increasing awareness
of microbiome offering targeted
treatment information
Consumer market Practitioner market
Growing market opportunity

6. 6
Leading microbiome test with world-class
measurement accuracy of your gut
microbiome & functional potential.
Delivers evidence-based personalised dietary
& lifestyle modifications to improve gut
health.
Why Microba’s gut microbiome test?

7. 7
Metagenomic mapping technology
delivering leading microbiome
measurement when combined
with Microba’s Genome Database
Microba
Community Profiler
Microba
Genome Database
World leading, expertly curated microbial
genome reference database of microbial
genomes to deliver unmatched detection
coverage of the human microbiome
Assigns 25% more
DNA reads per sample
80-90% of the DNA is
identified and assigned*
Reports 4-16x’s less
false positive species
98% specificity*
Superior detection limit of
0.007%*
20 to 60 times
more sensitive
Outperforms other
profilers by 5–20%
96% accuracy*
Identify majority
species with
>99% identity
We measure the microbiome with unparalleled performance
Delivering the highest level of resolution, accuracy and precision
We see more We are precise We are world-class We are accurate We are confident
* Parks et al 2020, unpublished

8. 9
Experts & thought leaders
in the analysis of complex
microbial communities
Published the first paper
to use metagenomics for
profiling microbial
communities1
Prof Phil Hugenholtz
Co-Founder
Recognised among the
world’s most influential
researchers of the past
decade in their fields3
Prof Gene Tyson
Co-Founder
Redefined the standards for
the systematic
classification of microbial
taxonomy2
1 Tyson GW, Chapman J, Hugenholtz P, et al. 2004. Community structure and metabolism through reconstruction of microbial genomes from the environment. Nature.
2 Parks D.H. et al. 2018. A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life. Nature Biotechnology.
3 https://publons.com/researcher/3119406/philip-hugenholtz/ https://publons.com/researcher/2663138/gene-w-tyson/
Founded by scientific leadership

9. 10
People’s Choice Award 2018
Award Winning
Australian Company
2019 Finalist
WINNER
Company snapshot – since June 2018 product launch
>10,000 customers
Strong revenues &
institutional investor
backing
Founders published the
first paper in the field of
microbial metagenomics
43 FTE
Including 18 PhDs
Offices in USA
and Australia
Leaders in the
development of industry
standard tools for
microbiome analysis
Products delivered for
partners in US, EU & AU
State-of-the-art high-
throughput lab operating
to NATA/ISO15189 &
privacy to GDPR standard
Founders in top 1% of
cited researchers globallyScientific Leadership
Commercial
Platform
Business Operations

10. 11
Microba analyses the entire genome with Metagenomics
Genome
shotgun metagenomics (whole genome)
Latest technologyvs.
16S rRNA gene (~0.1% of genome)
Outdated technology

11. 12
Metagenomics allows unprecedented detail into the gut microbiome
Species (57) Species (632)
16S rRNA gene
(outdated technology)
Shotgun metagenomics
(Microba approach)

12. 13
Metagenomics enables insight into function with high-resolution profiling
Faecalibacterium
prausnitzii
type A
Faecalibacterium
prausnitzii
type B
Faecalibacterium
prausnitzii
type C
Microba’s MetagenomicsCulture, 16S & other methods
Low butyrate
producer
Mucin degrader
Atopic dermatitis
Beneficial
anti-inflammatory
High butyrate producer
Faecalibacterium
Function
> Detrimental metabolites
produced
Function Function
> Beneficial metabolites
produced
Neutral metabolites
produced
Faecalibacterium
Faecalibacterium
Genus level descriptions
No functional insights
One genus Three species

13. 14
Microba’s proprietary analysis platform
Expert
Support
Consumer
Telehealth coach
service
Practitioner
Professional
support
Metagenomic
Measurement
Platform
Report
Platform
Dietary
suggestions
Patient sampling
Interactive
Patient Report
Ongoing
monitoring
Clinically
relevant
metadata
capture
Innovative swab
preservation
Metagenomic
sequencing
Bioinformatic
processing

14. 15
PRODUCT SHOWCASE

15. 16
Modular applications enable tailored solutions
Sampling Kits and Logistics
Online Results Portal
Gut Health Predictive Score
Key Insight Results
Prebiotic Food Selector
Top-5 species summary
Microbial Diversity
Complete Species Table
Microbial Metabolite Potentials
Sample Composition
Species-of-Interest (inc. Probiotics)
Language Packs &
Product Recommendations
Protein, Fibre and Mucus capacity
Interactive Species Explorer
✓
✓
✓
✓
✓
✓
✓
✓
✓
✓
✓
✓
✓
✓
Microbiome Coach Telehealth Support Questionnaire Health Summaries✓ ✓

16. 17
App 1 Sampling Kit - Non-invasive, user-friendly sampling preserves
sample without cold-storage or liquid
• Very simple sample capture for
high user compliance
• No need to directly handle your
stool. Simply swab your toilet
paper after use & close swab
• Swab is ready for postage using
supplied return envelope (4-
week sample stability in ambient
temperature)

17. 18
App 2 Gut Health Predictive Score
Microba
Community Profiler
=
A.I. Powered Predictive
Health Score
Microba
Genome Database
AU healthy
Spanish healthy
AU unhealthy
Advanced Machine
Learning

18. 19
• AI-based predictive
gut health score
• Indicates likelihood of
a healthy gut based
on machine-learning
• Comparison feature
lets users compare
reports & track
progress
App 2 Gut Health Predictive Score
Extract from demo customer report delivered through Microba online portal

19. 20
App 3 Key Insights – your individual microbiome, summarised simply
• Easy-to-read results
presented in a series
of short stories about
your gut
• Education and result
as a series of single-
point lessons
• Includes evidence-
ratings to help people
focus on what is
important
Extract from demo customer report delivered through Microba online portal

20. 21
• Provides the
microbiome’s capacity
to produce & consume
metabolites linked to
health
• Displays how you
compare within a health
range
• Includes TMA, LPS,
Hydrogen Sulphide,
Methane, GABA, Short
Chain Fatty Acids, &
Vitamins
• Can direct customers to
custom interventions
through diet &
supplements
App 4 Metabolic Functions
Screenshot from demo customer report delivered through Microba online portal

21. 22
• Shows the connection
between foods & gut
health
• Customisable tool for
generating “shopping
lists” for easy action
• Accounts for dietary
restrictions
• Can direct customers
to custom
interventions through
diet & supplements
App 5 Prebiotic Food Selector – for personalised dietary interventions
Extract from demo customer report delivered through Microba online portal

22. 23
Sourced from fermented
foods and supplements.
Unstable transition
through the stomach.
Varying species, strains and concentrations with
limited evidence. Commonly do not colonise in
the human gut.
Health benefits are
unknown/inconsistent in most
circumstances.
Prebiotics
Prebiotic intervention model - Promoting the growth of beneficial bacteria
Prebiotics are
non-digestible
compounds that
promote the growth
of beneficial bacteria
in the gut.
Probiotics
Sourced from foods
& supplements.
Stable transition
to the lower
gastrointestinal tract. Targeted
fuel source

23. 24
• Telehealth support
services to make the
most of the results
• Book a time using an
integrated online tool
• Support provided by
accredited health care
professionals
App 6 Microbiome coach - telehealth support
Extract from demo customer report delivered through Microba online portal

24. 25
Phylum Species Abundance Range Level
Firmicutes_A Coprococcus sp 0.59% 0.00% - 0.00% High
Firmicutes_A Blautia_A wexlerae 0.97% 0.00% - 1.64% Average
Firmicutes_A CAG-632 sp 1.55% 0.00% - 0.00% High
Firmicutes_A Butyrivibrio_A sp 0.83% 0.00% - 0.00% High
Firmicutes_A Agathobacter faecis 1.69% 0.00% - 1.52% High
Firmicutes_A Coprococcus_B comes 0.32% 0.00% - 0.48% Average
Firmicutes_A CAG-127 sp2 0.60% 0.00% - 0.75% Average
Firmicutes_A Ruminococcus_B faecis 0.51% 0.00% - 0.61% Average
Firmicutes_A Agathobacter rectalis 1.54% 0.00% - 4.87% Average
Firmicutes_A Dorea longicatena 0.79% 0.00% - 0.67% High
Firmicutes_A Fusicatenibacter saccharivorans 1.27% 0.00% - 2.29% Average
Bacteroidetes Prevotella copri 13.15% 0.00% - 25.35% Average
Firmicutes_A CAG-194 sp1 0.19% 0.00% - 0.17% High
Firmicutes_A Blautia_A sp 0.55% 0.00% - 0.38% High
Firmicutes_A UBA3626 sp 0.08% 0.00% - 0.00% High
Firmicutes_A Lachnospira rogosae 0.30% 0.00% - 0.81% Average
Firmicutes_A Butyrivibrio_A crossotus 0.58% 0.00% - 0.83% Average
Firmicutes_A CAG-245 sp1 0.16% 0.00% - 0.37% Average
Bacteroidetes Prevotella sp13 2.44% 0.00% - 0.19% High
Firmicutes_A Dorea formicigenerans 0.14% 0.00% - 0.21% Average
Firmicutes_A Ruminococcus_D bicirculans 1.41% 0.00% - 2.10% Average
Firmicutes_A Ruminiclostridium_E sp 0.32% 0.00% - 0.00% High
Firmicutes_A Coprococcus_A catus 0.06% 0.00% - 0.21% Average
Bacteroidetes Parabacteroides sp 0.13% 0.00% - 0.00% High
Firmicutes Catenibacterium sp 1.39% 0.00% - 0.00% High
Bacteroidetes Prevotellamassilia timonensis 2.03% 0.00% - 0.00% High
PDF Report
Options for data delivery
Integration via Microba’s APIs
Electronic PDF report deliveryRaw data delivery* Online Interactive Report
PDF of results in a
Partner-branded report
Embed Microba’s results
into your own report structure
Secure link to view results
Partner-branded Report
delivered by Microba
Your Microbiome
report
*Rapid Integration into your own
reporting solution

25. 26
Case study: measuring the microbiome for evidence-based health management
Eggerthella lenta = high
Clostridium perfringens = high
Klebsiella aerogenes= high
Histamine = highUses Microba’s at-
home microbiome
test
Supplement foods containing
prebiotics; FOS, pectin,
resistant starch
Prebiotic supplements such as
green banana flour, powdered
FOS, apple pectin capsule
Patient has
chronic
GI symptoms
Key findings RecommendationsPatient action
Symptom
resolution

26. 27
International partners who have chosen Microba
(integrative
practitioner-only
product)
Asia
India (in discussion)
South Korea
America
United States
Colombia
Europe
Spain
Rest of EU (in discussion)
Oceania
Australia
New Zealand

27. 28
Case study: myBiome™
with Synlab
• Synlab is Europe’s largest pathology
provider
• Sought Microba to deliver a
microbiome testing solution in
Europe
• New language support (translation
to Spanish)
• Established healthy cohort for
regional comparison
• Ensured data privacy in new
jurisdictions (GDPR compliance)

28. 29
Partnership models are bespoke
Partner 1
Microba
sales &
marketing
customer
training &
onboarding
outbound
logistics
inbound
logistics
sample
preparation
& quality
control
library prep
&
sequencing
bioinformatic
& report
generation
report
delivery
customer
support
Partner 2
Microba
sales &
marketing
customer
training &
onboarding
outbound
logistics
inbound
logistics
sample
preparation
& quality
control
library prep
&
sequencing
bioinformatic
& report
generation
report
delivery
customer
support

29. 30
Brand Leadership
• Microba’s industry-leading microbiome testing solution for evidence-
based gut health management.
Modular Platform
• Offering a tailored solution for Partner’s vision. Microba can manage as
much or as little of the testing, logistics & patient support as desired by
the Partner.
Track Record
• Proven track record of delivering products to regionally diverse partners.
Why partner with Microba?

30. microba.com
+61 427 439 633
kasra.sabermanesh@microba.com
Dr Kasra Sabermanesh
Regional Partnerships Manager