2. Tests for H.pylori
Diabact UBT
Helicobacter Test Hp-Plus®
Helicobacter Test INFAI®
Pylobactell®
3. Precautions
The test should not be performed within 4 weeks of
treatment with an antibacterial or within 2 weeks of
treatment with an antisecretory drug.
However, the appropriateness of testing for H.pylori
infection in children has not been established.
4. Drug regimens used
Anti-acids combined with anti-bacterials eradicate
H. pylori in 90% cases.
Failure of therapy is either due to poor copmliance or
resistance.
Reinfection is rare.
Before therapy, it should first be established that H.
pylori is the cause.
Antibiotic induced colitis is an uncommon risk.
5. Regimens principle
Triple therapy: It includes a p.p.i., Amoxil, and either
Clari or Metro for 14 days, or 7 days.
Two week therapy provides better eradication thn a 7
day though with increased adverse effects risk.
Regimens consisting a p.p.i. and an antibacterial are
licensed though offer less eradication than the triple
therapy thus not recommended.
6. Cont’d
Tinidazole or tetra used in combination with
antisecretory drugs and antibacterials also eradicate
H.pylori
Resistance to clari & metro during treatment is much
more common thn 2 Amoxil.
Thus a regimen with Amoxil & clari is indicated 4
initial therapy and that with Amoxil and metro 4
failure.
7. Cont’d
Ranitide bismuth citrate may be substituted for a
p.p.i.
Regimens consisting metro and Clari are for
specialist settings.
2 wk regimen of ppi+ tripotassium
dicitratobismusthate + 2 antibacterials may used 4
resistant cases.
8. Cont’d
There’s no need to continue antisecretory drugs &
H2-receptor antagonists after therapy unless there’s
complication of hemorrhage, and perforation.
Healing maybe compromised by use of NSAIDS