2. Why anaesthetists should be
concerned?
Perioperative drug interactions
Perioperative predisposition for
seizures
Epileptogenic potential for certain
anaesthetic drugs.
Airway management and general
anaesthesia for refractory status
epilepticus.
3.
4. What is epilepsy?
What is a seizure?
What is status epilepticus?
16. Inhalational agents
Nitrous oxide:
Proconvulsant in animal models.
Increases epileptiform activity intra
operatively.
Myoclonus observed in humans at
hyperbaric conditions.
17. Sevofurane:
proconvulsant in paediatric age groups.
Widespread epileptiform activity in
EEG.
Isoflurane and desflurane:
Anticonvulsant property.
Have been used in status epilepticus.
19. IV induction agents
Proconvulsant at low doses.
Anticonvulsant at higher doses.
Thiopentone and other barbiturates –
anticonvulsant
Propofol-anticonvulsant.Incidences of
myoclonus and opisthotonus have
been reported.
21. Skeletal muscle relaxants
Suxamethonium : contra indictaed in
SE.
Increased risk of rhabdomyolysis and
hyperkalemia.
Atracurium and cisatracurium:
Laudonosine metabolite has
epileptogenic potential.
AED being enzyme inducers:
decreases the potency of NDMR.
22. SMR masks seizures intraoperatively.
How to diagnose?