This document outlines coverage criteria for the medication Truvada (emtricitabine/tenofovir disoproxil fumarate) for the treatment of HIV infection, post-exposure prophylaxis to reduce the risk of HIV infection after occupational or non-occupational exposure, and pre-exposure prophylaxis to reduce the risk of sexually acquired HIV infection in high-risk adults. Initial authorization is approved for PrEP for 6 months if screening shows negative HIV status and counseling on safe sex practices has occurred. Reauthorization requires continued screening, counseling, and confirmation of high risk status. PEP is authorized for 1 month if initiated within 72 hours of exposure. Treatment of HIV infection is authorized for 60 months.