1. CONTACT
64 route de lyon, 84000 Avignon, France, @: jean.thomas.pierson@gmail.com Tel : +336 29732438
Natural
products
and
phytochemicals
expert
Project
Manager
for
extrac*on,
characterisa*on,
toxicology
and
biological
ac*vi*es
of
natural
extracts.
Biodiversity,
Tradi*onal
medicines
and
Ethnopharmacology
R&D
Scien<fic
coordinator
for
the
development
of
phytopharmaceu*cals,
Botanical
Drug
Substance,
nutraceu*cals
Jean
Thomas
PIERSON,
PhD
64
route
de
Lyon
84000
Avignon,
France
📞
:
+33
6
2973
2438
📧
:
jean.thomas.pierson@gmail.com
:
fr.linkedin.com/pub/jean-­‐thomas-­‐pierson
ACADEMIC
QUALIFICATIONS
2004
-­‐
2008 PhD
*tle
:
Synthesis
of
bio-­‐evalua*on
of
new
an*-­‐mito*c
compounds
of
the
neoflavonoid
family.
Medicinal
Chemistry
S.R.E.P.
laboratory,
Université
d’Aix
Marseille
I,
Marseille,
France
Supervisor:
Pr.
Jean
Pierre
Finet
Occupa*on
and
main
realisa*on:
• Chemical
synthesis
and
biological
evalua*on
of
55
neoflavonoid
type
compounds
using
Suzuki-­‐Coupling
strategy.
• Pharmacology
studies
related
to
an*-­‐tubulin
and
an*-­‐parasi*c
ac*vi*es
(Leishmania
of
neoflavonoid
compounds
• QSAR
analysis
of
major
hits
• Publica*ons
in
peer
reviewed
journals
• Bibliography
2001
-­‐
2002 Masters
of
science
:
Bioorganic
and
bio-­‐inorganic
systems
(Receptology)
University
of
Paris
VI,
Paris,
France
Masters
research
project
:
Chi*n
synthase
inhibi*on
through
radiolabeling
bioassays
2000
-­‐
2001 Bachelor
of
science
:
Chemistry
Majors
:
Bioorganic
chemistry
University
of
Paris
VI,
Paris,
France
1999
-­‐
2000 Advanced
diploma
:
Chemistry
University
of
Paris
VI,
Paris,
France
MEDICINAL CHEMISTRY DOCTOR
RESEARCH OFFICER
(8 years experience)
Phytochemistry - Natural Products

2. CONTACT
64 route de lyon, 84000 Avignon, France, @: jean.thomas.pierson@gmail.com Tel : +336 29732438
PROFESSIONAL
EXPERIENCE
2013
-­‐
2015 Scienfic
Project
coordinator
-­‐
Extrac*on,
Purifica*on
and
process
design
of
a
Botanical
Drug
Substance
for
pharmaceu*cal
industry,
RD
NATPharma,
Dr.
Antoine
Bily.
NATUREX,
Avignon,
France
Occupa*on
:
• Extrac*on,
characterisa*on
and
process
design
for
the
scale
up
development
of
a
natural
extract
in
a
GMP-­‐Pharma
environment.
• Natural
product
extract
characterisa*on
(HPLC
-­‐
HPTLC)
• Support
for
the
defini*on
of
specifica*ons
and
cri*cal
parameters.
• Scien*fic
expert
and
coordinator
in
a
mul*-­‐disciplinary
team
(RD,
industrial,
pharma
regulatory,
agricultural,
supply,
QC-­‐QA).
• Problem
solving
and
troubleshoo*ng.
• Reports
wri*ng
and
oral
presenta*ons
to
the
client.
• Bibliographic
research
for
the
phytochemical
and
tradi*onal
uses
of
diverse
botanical
sources.
Main
realisa*on
:
Laboratory
to
industrial
scale
up
produc*on
of
conform-­‐to-­‐specifica*ons
BDS
to
be
used
in
clinical
trials.
Documenta*on
and
communica*ons
to
client.
2013-­‐2013 Postdoc
fellow
-­‐
Eco-­‐extrac*on
of
natural
products
from
vegetables
using
innova*ve
techniques
Laboratoire
G.R.E.E.N.
UMR
A
408,
Pr.
Farid
Chemat,
Université
d’Avignon
et
des
pays
du
Vaucluse,
Avignon,
France
Occupa*on
:
• Extrac*on
of
phytochemical
components
from
leluce
(microwave
hydrodiffusion
and
gravity),
tomato
(Ultrasound),
and
spices
(Turbohydrodis*lla*on)
• Characteriza*on
of
phytochemicals
from
natural
extracts
(essen*al
oils
(GC),
vegetable
juice
(HPLC).
Encapsula*on
of
phytochemicals
in
beta-­‐cyclodextrins.
• Publica*on
and
communica*on
redac*on
and
correc*ons
Students
supervision
(MSc)
Project
management
Main
realisa*on
:
Ecological
extrac*on
and
pilot
setup
of
phytochemical
extrac*on
using
microwave
technologies.

3. COMMUNICATIONS
BOOK
CHAPTER
2015
Green
extrac*on
of
natural
products,
Chapter
1
:
Green
Extrac*on:
from
concepts
to
research,
educa*on
and
economical
opportuni*es.
Wiley,
ISBN
978-­‐3-­‐527-­‐33653-­‐1.
PATENT
2015
TBA
(May
2015)
PUBLICATIONS
2015
Estrogen
Modula/on
Proper/es
of
Mango
Fruit
Components
Mangiferin
and
Querce/n
and
the
Puta/ve
Mangiferin
Metabolite
Norathyriol.
Wilkinson
et
al..
Molecular
CONTACT
64 route de lyon, 84000 Avignon, France, @: jean.thomas.pierson@gmail.com Tel : +336 29732438
2009-­‐2012
Postdoc
fellow
-­‐
Mango
bioac*ves
characteriza*on
-­‐
Chemistry
and
Pharmacology.
P.A.C.E.
Pr.
Nick
Shaw,
Pr
Greg
Monteith,
Pr
Mike
Gidley.
School
of
Pharmacy,
University
of
Queensland,
Brisbane,
Australia,
Occupa*on
:
Natural
Product
extrac*on,
isola*on
and
purifica*on
of
tropical
fruits
Phytochemical
content
and
characteriza*on
of
tropical
fruits
using
high
throughput
analysis
Pharmacological
studies
on
a
kera*nocyte
inflamma*on
model
Publica*on
and
communica*on
redac*on
and
correc*ons
Student
supervision
(PhD,
Hons)
Prac*ce
Classes
teaching
(2nd
year)
Chemical
safety
officer
(storage,
disposal,
OHS)
Main
realisa*on
:
Setup
and
troubleshoo*ng
of
a
high
throughput
analysis
equipment
Design
of
in
vitro
skin
inflamma*on
model
1996
THROUGH
2004
Internship,
Macromolecular
branched
polymers
synthesis
Specific
Polymers,
ENSCM,
Montpellier,
France
Internship,
Marie
Curie,
Paris
VI,
France
Internship,
Frog
skin
pep/des
synthesis
and
structural
characteriza/on
Université
Pierre
et
Marie
Curie,
Paris
VI,
France.
Internship,
SG1
nitroxide
full
synthesis
Université
de
Provence,
Marseille,
France
Internship,
Polyvinyl
chloride
industrial
produc/on
Elf
Atochem,
Saint
Fons,
France

4. nutrion
and
Food
Research
(in
review)
2015
Polyphenolic
Contents
and
the
Effects
on
Breast
Cancer
Cells
of
Methanolic
Extracts
from
Various
Mango
Varie/es.
Hoang
et
al.
Korean
Society
of
Food
Science
and
Technology
(in
review)
2015
Laboratory
to
pilot-­‐scale
op/miza/on
of
microwave
hydrodiffusion
and
gravity:
solvent-­‐free
extrac/on
of
polyphenols
from
leMuce.
Pierson
et
al.,
Food
science
and
Technology,
(in
review)
2014
Phytochemical
extrac/on,
characterisa/on
and
compara/ve
distribu/on
across
four
mango
(Mangifera
indica
L.)
fruit
varie/es.
Pierson,
et
al.,
2014.
Food
chemistry,
149,
253–
263.
2013
Mango
(Mangifera
indica
L.)
peel
extract
frac/ons
from
different
cul/vars
differen/ally
affect
lipid
accumula/on
in
3T3-­‐L1
adipocyte
cells.
Taing
et
al.,
2013,
Food
func-on,
4(3),
481–491
2012
Mango
fruit
peel
and
flesh
extracts
affect
adipogenesis
in
3T3-­‐L1
cells.
Taing
et
al.
2012.
Food
func-on,
3(8),
828–836
2012
Major
Australian
tropical
fruits
biodiversity:
Bioac/ve
compounds
and
their
bioac/vi/es,
Pierson
et
al.,2012,
Mol.
Nutr.
Food
Res.,
56:
357–387.
2011
Synthesis
and
Biological
Evalua/on
of
4-­‐Arylcoumarin
Analogues
of
Combretasta/ns.
Part
2.
Combes
et
al.,
2011
J.
Med.
Chem.,
54,
3153-­‐3162.
2011
Bioac/vity
of
Mango
Flesh
and
Peel
Extracts
on
Peroxisome
Proliferator-­‐Ac/vated
Receptor
gamma
[PPAR
gamma]
Ac/va/on
and
MCF-­‐7
Cell
Prolifera/on:
Frac/on
and
Fruit
Variability.
Wilkinson
et
al.,
2011,
J.
Food.
Sci.,
76,
H11-­‐H18.
2010
Mango
Extracts
and
the
Mango
Component
Mangiferin
Promote
Endothelial
Cell
Migra/on.
N.
H.
Daud,
C.
S.
Aung,
A.
K.
Hewavitharana,
Wilkinson
et
al.,
2010
J.
Agr.
Food.
Chem.,
58,
5181-­‐5186.
2010
Synthesis
and
an/protozoal
ac/vity
of
4-­‐arylcoumarins.
Pierson
et
al.,
2010,
Eur.
J.
Med.
Chem.,
45,
(3),
864-­‐869.
TRAINING
AND
WORKSHOPS
Go8
Future
Research
Leaders
Program
-­‐
Project
management.
Agilent
Qtof
training
-­‐
Mass
Spectrometry,
Chemwatch
Gold
Training
-­‐
OHS
for
chemicals
storage
and
disposal
Uniquest
commercializaon
workshop
-­‐
IP
and
commercializa*on
REFEREES
Pr.
Nick
Shaw
Ph:
+61
7-­‐334-­‐61701;
Email:
n.shaw@pharmacy.uq.edu.au
(UQ,
Australia)
Pr.
Farid
Chemat;
Email
:
farid.chemat@univ-­‐avignon.fr
(UAPV,
Avignon,
France)
Pr.
Greg
Monteith
Ph:
+61
7-­‐334-­‐61855;
Email
g.monteith@pharmacy.uq.edu.au
(UQ,
Australia)
CONTACT
64 route de lyon, 84000 Avignon, France, @: jean.thomas.pierson@gmail.com Tel : +336 29732438