Good Stuff Happens in 1:1 Meetings: Why you need them and how to do them well
Inhibitor Table
1. HpMTAN
Inhibitor Ki Ki*
9fpm 0.81 ± 0.01 nM 0.24 ± 0.02 nM
PT03-159
H
N
HO OH
NH
N
N
NH2
S
0.54 ± 0.17 nM 0.22 ± 0.04 nM
PT02-159 (?)
H
N
HO OH
H
N
N
N
NH2
SCl
2.42 ± 0.51 nM 2.33 ± 0.13 nM
PT-02-186
H
N
HO OH
H
N
N
N
NH2
S
N/A
PCLMT-O-A (?)
H
N
HO OH
H
N
N
N
NH2
OCl
0.11 ± 0.03 nM 0.08 ± 0.02 nM
OVZN709 N/A
2. KC9-156
H
N
HO OH
H
N
N
N
NH2
S
O
Me
O
N/A
KC9-15 (?)
H
N
HO OH
H
N
N
N
NH2
S
O
Me
N/A
KC8169A N/A
JM132A 0.27 ± 0.04 nM .04 ± 0.01 nM
JM129 0.32 ± 0.01 nM N/A
JM1-579 N/A
DHL-159 0.21 ± 0.05 nM 0.01 ± 0.03 nM
DHL140 N/A
AIL091486 0.58 ± 0.19 nM 0.41 ± 0.06 nM
KC9-15-C N/A
Bn-D-A 0.29 ± 0.04 nM 0.31 ± 0.08 nM
mMe-Phe-A 1.50 ± 0.26 nM 2.11 ± 0.11 nM
pMe-phe-A 1.89 ± 0.21 nM 2.63 ± 0.26 nM