2. Objectives
• To discuss gastro duodenal mucosal barrier
• To discuss pathophysiology of peptic ulcer disease
• To discuss physiology of peptic ulcer disease treament
3. Introduction
• Mucosa lining excoriation
extending to muscularis
mucosae
• Disruption of balance
between aggressive and
protective factors
• 1,576 (0.42%) deaths in
Tanzania in 2017 (WHO)
Picture Source: dr. michael koeplin
5. Clinical Presentation and Classification
Duodenal Gastric
more associated with acid hyper
secretion
more associated with acid mucosa
protection damage
pain felt later following meal 2-3
hours
pain felt earlier following meal ½-1
hours
pain often felt in the night or
early morning
often relieved by eating or anti-
acids
not relieved by eating ( may
exacerbate) or anti-acids
may lead to weight gain may lead to weight loss
less associated with vomiting often associated with vomiting
common in lower ages common in advanced ages
relatively common esp. in men relatively les common (3:1)
9. • Gastric hyper secretion: due to either
i. Imbalance between D (secreting Somatostatin) and G
(secreting gastrin) cells function
– Zollinger-Ellison Syndrome: gastrin secreting tumor
– Impaired inhibitory mechanisms
ii. Physiological stress
– Enhanced stimulation and response to vagal stimulation: e.g.
Head injury, brain tumor, infections: Cushing’s ulcer
– Severe burn: Curling’s ulcer
14. Peptic Ulcer Complications
• Intractable
pain
• Obstruction
– Especially at
the pylorus:
healing with
fibrosis
• Malignancy:
rarely
15. References
1. Despopoulos (2003) Color Atlas of Physiology Thieme
2. Fox, Stuart Ira Human Physiology, 12th ed
3. Guyton and Hall Text of Medical Physiology 11th ed
4. https://michaelkoeplinmd.com/peptic-ulcer-disease-causes-symptoms-and-treatment/
5. https://emedicine.medscape.com/article/181753-overview#a6
6. https://en.wikipedia.org/wiki/File:Stomach_mucosal_layer_english_labels.svg
7. https://www.nejm.org/doi/full/10.1056/NEJM199003293221307
8. hopkinsmedicine.org/gastroenterology_hepatology/_pdfs/esophagus_stomach/peptic_ulcer_disease.pd
f
9. Kumar, pavan & narayan, naveen & Mahajan, vikrant. (2013). A clinico-pathological study of duodenal
ulcer perforation and its management in a rural area in karnataka. International journal of medical and
applied sciences. 2. 47.
10.https://www.medscape.com/answers/181753-13856/does-smoking-alcohol-or-caffeine-increase-the-
risk-of-peptic-ulcer-disease-pud
Editor's Notes
Tight junctions: prevents backflow of H+ and pepsin
The surfactant molecules of the gastric epithelium have each two hydrophobic hydrocarbon chains that are orientated out at the exterior surface. These surfactants may prevent water-soluble agents in the gastric lumen from reaching and damaging the epithelial cells. Salicylate and sodium deoxycholate result in a rapid decrease in the hydrophobicity of the mucosa
Prostaglandins are found in high concentration in the gastric mucosa and gastric juice. Exogenous prostaglandins inhibit acid secretion, stimulate mucus and bicarbonate secretion, alter mucosal blood flow, and provide dramatic protection against a wide variety of agents which cause acute mucosal damage. There is now strong evidence that endogenous prostaglandins modulate acid secretion by blocking the histamine-stimulated increase in cyclic AMP within the parietal cell
Other factors: balance btn D (Somatostatin) and G (gastrin) cells,
Urease: immune reaction
Endotoxins: lipopolysaccharide and PLP
Ammonium hydroxide
Elevated gastrin secretion: alkaline by ammonium, reduced D cells
Elevated acid secretion: proliferation of parietal ells
Brain tumors, traumatic head injury, and other intracranial processes including infections, can cause increased intracranial pressure and lead to overstimulation of the vagus nerve.Efferent fibers of the vagus nerve then release acetylcholine onto gastric parietal cell M3 receptors, causing insertion of hydrogen potassium ATPase vesicles into the apical plasma membrane
Curling's ulcer is an acute gastric erosion resulting as a complication from severe burns when reduced plasma volume leads to ischemia and cell necrosis (sloughing) of the gastric mucosa