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 Current & Future Trends in
   Physician E-Sampling



                           %




Managing For Superior Sales, Access,
      Service & Cost Benefits


              Copyright © Best Practices®, LLC
          Physician E-Sampling Process Management   BEST PRACTICES,®
                                                                       LLC
Table of Contents



Project Overview
Key Insights & Findings
Origin and Strategy of Physician E-Sampling
Sample Program
Launching and Managing Physician E-Sampling
System
Technology and Applications to Enable Physician
E-Sampling Systems
Measuring and Managing Physician E-Sampling
System
Appendix
  Additional Quotes           1
            Copyright © Best Practices®, LLC
  About PhysicianPractices Management
        Best E-Sampling Process                BEST PRACTICES,®
                                                                  LLC
Business Issue & Corporate Challenge
Best Practices, LLC designed this research study to identify and document current
practices and trends in Physician E-Sampling across the biopharmaceutical industry.


 Background:
     Benchmark how pharmaceutical companies organize their efforts in Physician E-Sampling
     Identify common organizational structures, budget structures, and measure management processes
     Gain insight into trends, challenges, and lessons learned in serving this market




  Field Research & Insight Development:
  Interviewed leaders in Physician Sampling at top
  Pharma companies                                          INFORM
                                                            INFORM
                                                                            Use Insights To Inform &
  Engaged 31 external executives & 22 companies
                                                                              Inspire Physician E-
  Segments composed of 16 different therapeutic
  areas including diabetes/metabolic, cardiology,
                                                                               Sampling Strategy
  respiratory, oncology and others




                                                                                         BEST PRACTICES,
                                                        2                                                  ®
                                         Copyright © Best Practices®, LLC                                      LLC
Universe of Learning: Companies Participating
in Study
Thirty one research respondents from 22 companies participated in this project. The
majority of companies in this study represent United States operations, with 9 of the
top 21 pharmaceutical companies surveyed.




                                                  3
                                 Copyright © Best Practices®, LLC
                             Physician E-Sampling Process Management   BEST PRACTICES,®
                                                                                          LLC
Job Titles & Levels of Participants
The range of titles suggests that Physician E-Sampling is evolving to be an integral
part of sales and marketing organizations. A third of the research participants hold
Vice President or Director leadership roles in their companies.



   Vice President                                         Channel Marketing Manager
   Vice President, Managed Care                           Country Sales Manager
   Executive Director                                     Marketing Manager
   Executive Director, Managed Markets                    Associate Director, Field Support
   Sr. Global Product Manager
                                                          Area Sales Manager
   Sr. Brand Manager
                                                          Area Manager
   Sr. Manager Samples Operations
                                                          Sr. Executive Sales Professionals
   Sr. Manager Sales
                                                          Sr. Manager
   Sr. Product Manager
   Director, Global e-Business                            Market Manager, Managed Care

   Director, Sales Specialist                             Manager, Hearing Healthcare Programs


                                                      4
                                     Copyright © Best Practices®, LLC
                                 Physician E-Sampling Process Management       BEST PRACTICES,®
                                                                                                  LLC
Framework for Presenting Physician E-Sampling S Insights,
Opportunities & Pitfalls
This report utilizes performance benchmarks and field research to harvest many of its
insights and observations. They have been organized into the following summary
framework for discussion, planning and improvement purposes.



                 8. Employ Multi-                          1. Align E-Sampling
                factor Scorecard To                             with Sales &
                Guide Improvement                           Marketing Strategy

     7. Manage for Access,                                               2. Place E-Sampling
         Service, Sales &                                                      With Right
          Cost Benefits          Physician E-                             Therapeutic Areas
                                   Sampling
      6. Call Plans Drive                                                  3. Choose Right
                                  Insights &                                 Outsourcing /
      Sample Distribution                                                    Insourcing for
           Volumes               Opportunities                                  Lifecycle

           5. Technology Enables                          4. Place E-Sampling
            Greater Productivity &                           Management in
                  Flexibility                              Appropriate Group
                                                    5
                                   Copyright © Best Practices®, LLC
                               Physician E-Sampling Process Management          BEST PRACTICES,®
                                                                                                   LLC
Key Findings & Insights – Physician E-Sampling
Trends & Drivers
Physician E-Sampling is well established across many companies and therapeutic areas. It
has become a key marketing and sales tactic in recent years.


      Physician E-Sampling Is Now An Established Tactic: Sales reps are still the primary
      sampling channel -- but Physician E-Sampling is growing and maturing. As sales resources shrink,
      companies look for efficient ways to access physicians. In the benchmark class at large, 1/3 of
      sampling has moved to Physician E-Sampling with 2/3 still delivered through sales reps. However,
      more companies are supplementing rep-based sampling with Physician E-Sampling and a few
      companies have moved to 100% Physician E-Sampling . For most, the Physician E-Sampling
      system is a field tactic coupled with individual products, therapeutic area or lifecycle. It is not yet a
      broad-based company-wide strategy among larger companies.

      Physician E-Sampling Reaches Across Therapeutic Areas: Physician E-Sampling has
      been seeded across multiple therapeutic areas – including diabetes and most other large chronic
      care areas. Physician E-Sampling has been in place for five or more years at many companies. Yet
      ¼ of the benchmark class is new to this channel. Physician E-Sampling innovation seems to be
      stimulated simultaneously by difficulty reaching physicians, sales resource limitations and
      evolving specialty models.

      Key Drivers of Physician E-Sampling Systems: Most companies implement Physician E-
      Sampling to address issues such as shrinking sales force and restricted access to physicians. In
      field commentaries, benchmark partners further spotlighted four principle benefits to Physician E-
      Sampling programs: (1) support increased sales, (2) increased physician access, (3) cost-
      effectiveness, and (4) helps build relationships.

                                                            6
                                           Copyright © Best Practices®, LLC
                                       Physician E-Sampling Process Management          BEST PRACTICES,     ®
                                                                                                                LLC
E-Sampling Requests Dependent on Therapeutic
Area Served and Companies’ Sales Structure
 Physician E-Sampling sample volume seems to reflect therapeutic areas served and market size. For
 example, immunology, metabolic and Gastrointestinal products often employed higher Physician E-
 Sampling sample volumes. Companies that ship high Physician E-Sampling sample volumes (more than 300
 Physician E-Sampling samples per month) tend to manage their own Physician E-Sampling programs.
      Q. How many Physician E-Sampling sample requests are typically processed on a monthly
                                             basis?

           More than 1000
           Monthly Sample                         0-100 Monthly
           Requests, 26%                             Sample
                                                  Requests, 30%
                                                                             75th Percentile        1,250
                                                                                  Mean              1,307
                                                                                 Median              500
                                                                             25th Percentile         100
         501-1000                                                           Nearly one in five companies
       Monthly Sample                                                       indicated that sample requests and
       Requests, 14%                                                        processing were dependent on
                                               101-500
                                                                            brands, therapeutic areas and
                                            Monthly Sample
                                            Requests, 30%
                                                                            product type.




                                                       7
   n=23                               Copyright © Best Practices®, LLC
                                  Physician E-Sampling Process Management            BEST PRACTICES,        ®
                                                                                                                LLC
Sales Representatives are Still the Primary Sampling
Mechanism but Physician E-Sampling is Growing
 As sales resources shrink, companies look for efficient ways to access physicians. In the
 benchmark class, only 1/3 of sampling has moved to Physician E-Sampling from sales
 reps. However, more companies are supplementing rep-based sampling with Physician E-
 Sampling and a few companies have moved to 100% Physician E-Sampling.
 Q. Overall what percentage of your company's brands are supported by Physician E-Sampling versus
 sales rep sampling at your company?

                Average DTP vs Sales Rep Sampling                                   Physician E-Sampling
                                                                                 75th Percentile    30

                                                 DTP Sampling,                       Mean           29
                                                     29%
                                                                                    Median          20
                                                                                 25th Percentile    10



                                                                                     Sales Rep Sampling
              Sales Rep                                                          75th Percentile    90
            Sampling, 71%
                                                                                     Mean           71
                                                                                    Median          80
                     •      Physician E-Sampling :
                            30%                                                  25th Percentile    70

     n=26            •      Sales Rep Sampling: 70%
                                                            8
                                           Copyright © Best Practices®, LLC
                                       Physician E-Sampling Process Management         BEST PRACTICES,    ®
                                                                                                              LLC
Physician E-Sampling Shipments to Reps
Lacks Set Timelines
Most companies have no set frequency in shipping Physician E-Sampling samples to
reps. Participants indicated that the frequency of shipment primarily depends on
therapeutic area and call plan objectives.


                Q. “How often do you ship samples to your sales reps?”


                  No set
                                                                                    80%
                frequency

               Do not ship
               samples to           8%
               sales reps


                 Bi-Weekly          8%



                    Other         4%


                             0%    10%    20%    30%    40%     50%    60%   70%   80%


   n=26
                                                       9
                                      Copyright © Best Practices®, LLC
                                  Physician E-Sampling Process Management                BEST PRACTICES,®
                                                                                                            LLC
Physician E-Sampling Innovation Focuses on
Supplemental Approaches
Field interviews spotlighted how various companies are adding new approaches that supplement their
existing computer-based Physician E-Sampling systems.

         VOICES FROM THE FIELD: COMMENTS FROM FIELD MANAGERS & LEADERS
           Additional Approaches To Complement Existing Systems
     •“We have a tele-sampling program where Physicians are called and asked if they would
     like samples. We have an Electronic Sample request (ESR) program where sample
     requests are initiated by representatives and then electronically sent to the vendor for
     fulfillment.”
     •“We use email requests, fax programs and a telesales team to conduct our Physician E-
     Sampling program.”
     •“Right now we do not have the technology for sales representatives in the field to order
     requests through a tablet/PDA. We can place orders on our tablet ordering system in
     Siebel, but you need an internet connection to complete the order.”




                                                       10
                                      Copyright © Best Practices®, LLC
                                  Physician E-Sampling Process Management     BEST PRACTICES,    ®
                                                                                                     LLC
75% See Physician E-Sampling Program as
Helpful to Sales and Marketing Efforts
Most find Physician E-Sampling to be helpful; however, only one in five companies
“strongly agree” that their companies Physician E-Sampling programs contribute greatly
to their Sales and Marketing efforts. Physician E-Sampling appears well seeded -- but not
fully mature in the field.
             Q. How much do you agree or disagree with the following statement?
“The Physician E-Sampling program positively contributes to the marketing and sales within your
                                         company.”                             75% agree that
                                                                                  Physician E-
                                                                               Sampling provides
          Strongly Agree                   21%
                                                                                positive support
                                                                                  for sales and
                                                                                   marketing.
                  Agree                                                    54%



                 Neutral                        21%



               Disagree     4%



       Strongly Disagree

   n=29
                                                      11
                                     Copyright © Best Practices®, LLC
                                 Physician E-Sampling Process Management    BEST PRACTICES,®
                                                                                               LLC
About Best Practices, LLC
Best Practices, LLC is a research and consulting firm that conducts work based on the simple, yet profound
principle that organizations can chart a course to superior economic performance by studying the best
business practices, operating tactics and winning strategies of world-class companies.




                              Best Practices, LLC
                              6350 Quadrangle Drive, Suite 200,
                                    Chapel Hill, NC 27517
                                  www3.best-in-class.com
                                      For more information contact:

                                                919.4037.0251
                                       best@best-in-class.com




                                                           12
                                          Copyright © Best Practices®, LLC
                                      Physician E-Sampling Process Management      BEST PRACTICES,    ®
                                                                                                          LLC

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E-Sampling Report Summary

  • 1. 0 Current & Future Trends in Physician E-Sampling % Managing For Superior Sales, Access, Service & Cost Benefits Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES,® LLC
  • 2. Table of Contents Project Overview Key Insights & Findings Origin and Strategy of Physician E-Sampling Sample Program Launching and Managing Physician E-Sampling System Technology and Applications to Enable Physician E-Sampling Systems Measuring and Managing Physician E-Sampling System Appendix Additional Quotes 1 Copyright © Best Practices®, LLC About PhysicianPractices Management Best E-Sampling Process BEST PRACTICES,® LLC
  • 3. Business Issue & Corporate Challenge Best Practices, LLC designed this research study to identify and document current practices and trends in Physician E-Sampling across the biopharmaceutical industry. Background: Benchmark how pharmaceutical companies organize their efforts in Physician E-Sampling Identify common organizational structures, budget structures, and measure management processes Gain insight into trends, challenges, and lessons learned in serving this market Field Research & Insight Development: Interviewed leaders in Physician Sampling at top Pharma companies INFORM INFORM Use Insights To Inform & Engaged 31 external executives & 22 companies Inspire Physician E- Segments composed of 16 different therapeutic areas including diabetes/metabolic, cardiology, Sampling Strategy respiratory, oncology and others BEST PRACTICES, 2 ® Copyright © Best Practices®, LLC LLC
  • 4. Universe of Learning: Companies Participating in Study Thirty one research respondents from 22 companies participated in this project. The majority of companies in this study represent United States operations, with 9 of the top 21 pharmaceutical companies surveyed. 3 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES,® LLC
  • 5. Job Titles & Levels of Participants The range of titles suggests that Physician E-Sampling is evolving to be an integral part of sales and marketing organizations. A third of the research participants hold Vice President or Director leadership roles in their companies. Vice President Channel Marketing Manager Vice President, Managed Care Country Sales Manager Executive Director Marketing Manager Executive Director, Managed Markets Associate Director, Field Support Sr. Global Product Manager Area Sales Manager Sr. Brand Manager Area Manager Sr. Manager Samples Operations Sr. Executive Sales Professionals Sr. Manager Sales Sr. Manager Sr. Product Manager Director, Global e-Business Market Manager, Managed Care Director, Sales Specialist Manager, Hearing Healthcare Programs 4 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES,® LLC
  • 6. Framework for Presenting Physician E-Sampling S Insights, Opportunities & Pitfalls This report utilizes performance benchmarks and field research to harvest many of its insights and observations. They have been organized into the following summary framework for discussion, planning and improvement purposes. 8. Employ Multi- 1. Align E-Sampling factor Scorecard To with Sales & Guide Improvement Marketing Strategy 7. Manage for Access, 2. Place E-Sampling Service, Sales & With Right Cost Benefits Physician E- Therapeutic Areas Sampling 6. Call Plans Drive 3. Choose Right Insights & Outsourcing / Sample Distribution Insourcing for Volumes Opportunities Lifecycle 5. Technology Enables 4. Place E-Sampling Greater Productivity & Management in Flexibility Appropriate Group 5 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES,® LLC
  • 7. Key Findings & Insights – Physician E-Sampling Trends & Drivers Physician E-Sampling is well established across many companies and therapeutic areas. It has become a key marketing and sales tactic in recent years. Physician E-Sampling Is Now An Established Tactic: Sales reps are still the primary sampling channel -- but Physician E-Sampling is growing and maturing. As sales resources shrink, companies look for efficient ways to access physicians. In the benchmark class at large, 1/3 of sampling has moved to Physician E-Sampling with 2/3 still delivered through sales reps. However, more companies are supplementing rep-based sampling with Physician E-Sampling and a few companies have moved to 100% Physician E-Sampling . For most, the Physician E-Sampling system is a field tactic coupled with individual products, therapeutic area or lifecycle. It is not yet a broad-based company-wide strategy among larger companies. Physician E-Sampling Reaches Across Therapeutic Areas: Physician E-Sampling has been seeded across multiple therapeutic areas – including diabetes and most other large chronic care areas. Physician E-Sampling has been in place for five or more years at many companies. Yet ¼ of the benchmark class is new to this channel. Physician E-Sampling innovation seems to be stimulated simultaneously by difficulty reaching physicians, sales resource limitations and evolving specialty models. Key Drivers of Physician E-Sampling Systems: Most companies implement Physician E- Sampling to address issues such as shrinking sales force and restricted access to physicians. In field commentaries, benchmark partners further spotlighted four principle benefits to Physician E- Sampling programs: (1) support increased sales, (2) increased physician access, (3) cost- effectiveness, and (4) helps build relationships. 6 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES, ® LLC
  • 8. E-Sampling Requests Dependent on Therapeutic Area Served and Companies’ Sales Structure Physician E-Sampling sample volume seems to reflect therapeutic areas served and market size. For example, immunology, metabolic and Gastrointestinal products often employed higher Physician E- Sampling sample volumes. Companies that ship high Physician E-Sampling sample volumes (more than 300 Physician E-Sampling samples per month) tend to manage their own Physician E-Sampling programs. Q. How many Physician E-Sampling sample requests are typically processed on a monthly basis? More than 1000 Monthly Sample 0-100 Monthly Requests, 26% Sample Requests, 30% 75th Percentile 1,250 Mean 1,307 Median 500 25th Percentile 100 501-1000 Nearly one in five companies Monthly Sample indicated that sample requests and Requests, 14% processing were dependent on 101-500 brands, therapeutic areas and Monthly Sample Requests, 30% product type. 7 n=23 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES, ® LLC
  • 9. Sales Representatives are Still the Primary Sampling Mechanism but Physician E-Sampling is Growing As sales resources shrink, companies look for efficient ways to access physicians. In the benchmark class, only 1/3 of sampling has moved to Physician E-Sampling from sales reps. However, more companies are supplementing rep-based sampling with Physician E- Sampling and a few companies have moved to 100% Physician E-Sampling. Q. Overall what percentage of your company's brands are supported by Physician E-Sampling versus sales rep sampling at your company? Average DTP vs Sales Rep Sampling Physician E-Sampling 75th Percentile 30 DTP Sampling, Mean 29 29% Median 20 25th Percentile 10 Sales Rep Sampling Sales Rep 75th Percentile 90 Sampling, 71% Mean 71 Median 80 • Physician E-Sampling : 30% 25th Percentile 70 n=26 • Sales Rep Sampling: 70% 8 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES, ® LLC
  • 10. Physician E-Sampling Shipments to Reps Lacks Set Timelines Most companies have no set frequency in shipping Physician E-Sampling samples to reps. Participants indicated that the frequency of shipment primarily depends on therapeutic area and call plan objectives. Q. “How often do you ship samples to your sales reps?” No set 80% frequency Do not ship samples to 8% sales reps Bi-Weekly 8% Other 4% 0% 10% 20% 30% 40% 50% 60% 70% 80% n=26 9 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES,® LLC
  • 11. Physician E-Sampling Innovation Focuses on Supplemental Approaches Field interviews spotlighted how various companies are adding new approaches that supplement their existing computer-based Physician E-Sampling systems. VOICES FROM THE FIELD: COMMENTS FROM FIELD MANAGERS & LEADERS Additional Approaches To Complement Existing Systems •“We have a tele-sampling program where Physicians are called and asked if they would like samples. We have an Electronic Sample request (ESR) program where sample requests are initiated by representatives and then electronically sent to the vendor for fulfillment.” •“We use email requests, fax programs and a telesales team to conduct our Physician E- Sampling program.” •“Right now we do not have the technology for sales representatives in the field to order requests through a tablet/PDA. We can place orders on our tablet ordering system in Siebel, but you need an internet connection to complete the order.” 10 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES, ® LLC
  • 12. 75% See Physician E-Sampling Program as Helpful to Sales and Marketing Efforts Most find Physician E-Sampling to be helpful; however, only one in five companies “strongly agree” that their companies Physician E-Sampling programs contribute greatly to their Sales and Marketing efforts. Physician E-Sampling appears well seeded -- but not fully mature in the field. Q. How much do you agree or disagree with the following statement? “The Physician E-Sampling program positively contributes to the marketing and sales within your company.” 75% agree that Physician E- Sampling provides Strongly Agree 21% positive support for sales and marketing. Agree 54% Neutral 21% Disagree 4% Strongly Disagree n=29 11 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES,® LLC
  • 13. About Best Practices, LLC Best Practices, LLC is a research and consulting firm that conducts work based on the simple, yet profound principle that organizations can chart a course to superior economic performance by studying the best business practices, operating tactics and winning strategies of world-class companies. Best Practices, LLC 6350 Quadrangle Drive, Suite 200, Chapel Hill, NC 27517 www3.best-in-class.com For more information contact: 919.4037.0251 best@best-in-class.com 12 Copyright © Best Practices®, LLC Physician E-Sampling Process Management BEST PRACTICES, ® LLC