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Biosensors Final Presentation - Fall 2015
- 2. Importance
• Hundreds of thousands of deaths from treatable
diseases in each year
• Early detection increases survival rates
© Israel Flores 2016
- 3. Our Goal
• Early diagnosis the key to effectively
treating diseases like cancer.
• Low Cost
• Point of Care Diagnosis
• Portable Biosensor
To develop a Point-of-Care (POC) Biosensor for medical diagnosis
to monitor health status
© Israel Flores 2016
- 5. Why CD-based Microfluidics?
• Optical system requires fluid to be in a
~2.5 µm cavity
• Microfluidics effectively transports fluid
from input to sensing region
• CD-based design:
• Space effective
• Cost effective
• Controllable fluid flow
© Israel Flores 2016
- 9. Channel Selection
• Fluid ‘split’ in channels with a large
change in cross-section
• Fluid continuous in uniform channels
• Easier to fabricate
• 1 mm channel width
© Israel Flores 2016
- 11. Results
• Spinning necessary to transport fluid
to waste reservoir
• Goals:
• Use calibration fluid
• Reusable channels
© Israel Flores 2016
- 12. Future Plan
• Disc design improvements
• Simplify microfabrication
• Easier to align sensing region
• 4 identical channels on each disk
• Functionalization of sensing region surface with bioreceptors
© Israel Flores 2016
- 20. Control System
• Precise positioning of disk
• Closed loop control
• User friendly
Rotate CD at high
RPM for a specified
period of time
Stop CD at a specific angle
© Israel Flores 2016
- 21. Our Approach
• Dual-Motor system
- Stepper Motor
- DC Motor
- Pulley Connection
• Stepper motor allows for precise
positioning
• DC Motor enables rotation speeds up to
4600 RPM
• IR sensor is used for reference point
© Israel Flores 2016
- 25. Photonic
Early
Diagnoses
Combine different wavelength lasers
and shooting them at the sample
The brains of the operation, interpret
detection results from the process
Detecting changes in wavelength
Move sample through disc and
position across laser beam
Optics
Sample
Detection
Processing
© Israel Flores 2016
- 33. Progress Report
• New Library
• Camera Interface
• Successful Data
Frame Exchange
Team Friendly Software for
rapid test script development
© Israel Flores 2016
- 36. Gantt Chart Spring 2016
Enclosure System
Biodetection Fabrication technique
Microcomputer Stand alone system
Optics detection
Microfluidics Stage 1
Enclosure System Final Design
Biodetection
Microcomputer
Optics
Microfluidics
Final Device Complete
5/19/1888 3/27/1924 2/3/1960 12/11/1995 10/18/2031
© Israel Flores 2016
