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A scan biometry
Presenter: Dr. Kshama K
IOL FELLOW
RJ SANKARA EYE HOSPITAL,
NEW PANVEL
Ocular Biometry
• Word meaning of biometry: measurement of tissues
• Components of ocular biometry include
• Measurement of axial length
• Measurement of corneal dioptric power
• IOL formulae and IOL power calculations
• The key issue faced in selecting an accurate power IOL is obtaining
accurate measurements and selection of optimal IOL calculation
formula.
Axial length measurements
• Different methods to measure the axial length of the eye ball
• Ultrasound
• A scan : applanation and immersion a scan
• B scan
• Optical Biometer
Ultrasound A scan
• One dimensional scan in which echoes are represented as vertical
spikes from baseline
• 1mm error in AXL – 2.35D error
• Axial length has to be repeated if difference between 2 eyes is 0.3
mm or if there is difference of 0.2 mm in consequtive readings
• Time required for sound pulse to travel from probe to interface is
noted
• Velocity of sound in different medium is known
• 1620 m/s in cornea
• 1641 m/s in lens
• 1629 in dense cataract
• 1630 m/s sclera
• 1532 m/s in aqueous and vitreous
• 986 m/s in silicone oil
• 2718 m/s PMMA
• Knowing time and velocity distance between two spikes gives the
length / AXL
Ultrasound waves have frequency greater than
20khz (20,000 oscillations/sec),inaudible to
human ears.
Audible Sound Waves : 20-20,000 Hz
• Diagnostic ophthalmology utilizes frequency of 8-10 Mhz
(1Mhz=1,000,000 cycles/sec)
• High frequencies produces short wavelength <0.2mm, which allows
resolution of minute ocular structure.
• Lower frequency produce longer wavelength
Principles of Ultrasound
• Reflectivity
• When sound wave travels part of the sound is reflected from the interfaces
into the probe -echo.
• Greater the density difference at the interface, stronger the echo
• stronger echo : higher the spike in A-scan and brighter the dots in B-scan.
• Velocity
• Angle of incidence
perpendicular
angle of incidence will be equal to the angle of
reflection
oblique
part of the echo is reflected away from the p
tip
weaker echo than the perpendicular sound
incidence
Less energy is returned
displayed image is compromised.
Probes
• first generation of contact biometers: water-filled probes with a soft
membranous tip.
• filled with distilled water,
• small air bubbles trapped : erroneous AEL
• Newer biometers : solid probes
• Applanation/ contact vs immersion probes
• 10-12 MHz
• Focused vs non focused beam
Applanation probe
Instrumentation
Instrument Settings
• (1) measurement mode,
• (2) eye type,
• (3) position of electronic gates or cursors, and
• (4) gain.
Measurement Mode (Automatic vs. Manual)
Automatic Measurement Mode
In automatic continuous measurement mode the software uses standard settings for gain, gates and
detection threshold.
Beep is heard after each reading. Beep indicates valid scan , and momentarily freezes the scan pattern
on the screen.
Rapid
10 reading are taken continuously .
Used for most of the cooperative patients with normal cataract eyes.
Manual Measurement Mode
The A-scan will recognise the valid pattern
freeze the amplitude pattern for 2 seconds after which the screen is reset.
if the biometrist decides to retain the reading, press the freeze button.
Eye type ( Sound velocity)
• velocity setting on the instrument should
always be checked prior to beginning the
examination.
• phakic eye:
• Avg sound velocity setting : 1550 m/s
• Assumes constant relationship btwn lens thickness and
the depth of the anterior chamber.
• sufficient for measuring the normal phakic eye , small
errors in thick and thin lenses, long or short eyes
• Measure components separately and add the AXL
• VELOCITY CONVERSION EQUATION can be
used if uncorrect velocity is used
Gates
• Electronic calipers that
measure between two points
• Auto mode : gate position
decided by the machine
• Manual mode : gate position
decided by operator
Gain setting
• degree of echo amplification in an ultrasound system.
• beginning of an examination, the gain must be high – align grossly
along the visual axis to see overall appearance of echo gram
• Reduce gain to medium level – improve resolution of spikes
• High gain – artefact spike is tall and confused with Retinal spike –
short AXL
• Low gain – small retinal spike – adjacent scleral spike might be
misread as retinal spike – longer AXL
EXAMINATION PROCEDURES FOR A-SCAN
BIOMETRY
• history and explaining the examination to the patient.
• Patient Positioning
• Applanation : chin rest
• Hand held contact : sitting/reclining
• Immersion : supine / recliner/ supine with chin elevation
• Silicone filled eyes : sitting with no head tilting back
• instrument settings adjusted
• both eyes measured whenever possible
• Actual measurement
Contact Technique
• probe placed gently on the center of the cornea
• no ointment or excess fluid : erroneously high AXL
• Steps to minimise corneal compression
• If manual mode :
• measurement taken as soon as the probe touches cornea.
• Probe is removed before taking subsequent measurements: intermittent probe contact
• Pt asked to blink
• Each reading to see ACD
• 3 high quality readings
Applanation method.
• Pressure sensitive probe can be used
• Joystick is retracted as far away as possible
• joystick is then advanced until the probe gently touches the center of
thecornea.
Handheld method
• cornea is more easily compressed with
this technique than with the
applanation method.
• When a pressure sensitive sleeve is not
employed, the patient should be
reclined.
• When pt seated upright , examiner
should observe cornea from side to
minimise compression
Immersion Technique
• employs a small water bath – hence corneal compression avoided
• separate corneal spike (not present in the contact method) -facilitate
alignment of the sound beam along visual axis.
• Avoid air bubbles
Ossoinig Hansen
Immersion a scan
Prager shell
An advantage of this shell is that it allows the immersion ex- amination
to be performed with the patient sitting upright rather than reclined.
• examiner immerses the probe into the fluid just until an echogram si
displayed.
• tip located approximately 3⁄8inch from the bottom of the shell.
• balanced salt solution
• double-peaked corneal spike and single-peaked spikes from the
anterior and posterior lens surfaces, retina, and sclera.
• 3 high quality reading
fluid for immersion
• If Hansen scleral shells are used : CMC 1%
• If prager shell: BSS (slightly hypotonic) or CMC 0.5%
• goniosol: hypromellose 40ml
• Dacriose: 60ml
• Isotonic, Buffered Solution of Purified Water, Sodium
Phosphate, Potassium Chloride, Sodium Hydroxide, Edetate
Disodium and Sodium Chloride, Preserved with Benzalkonium
Chloride 0.1 mg/ml.
Measurement of Phakic Eye
• Phakic setting is used
• Phakic setting works in 3 way depending on the instrument
• In extremely dense cataracts :
• Sound attenuation : weakening of retinal spike – prolonged measuring time
• Manual mode / dense cataract mode to be used
Measurement of Phakic Eye
• 3WAYS
• 2 gates
• between initial spike and retinal spike
• Preset avg sound velocity – 1550 m/sec
• 4 gates
• AC depth measured using 1532 m/s
• LENS thickness using 1641 m/s
• vitreous cavity using 1532 m/s
• ACD+LT+VL = AXL
• Aphakic sound velocity setting of 1532 m/s
• Uses 2 gates
• AXL measured + CALF (0.32 mm)CALF depends on the lens thickness for the age
• CALF changes with density of cataract
• Avg CALF value for most cataract pts is 0.32
Multiple signals
• Between ant n posterior lens capsule
• due to interfaces within a cataractous lens
• In vitreous baseline (reverberations) :
• These decrease with decrease in gain
• caution should be exercised in using the automatic mode when
multiple signals are present: the instrument may place one or more
gates on the wrong spikes, resulting in erroneous measurement
A scan of a moderately dense Cataract:. Spikes between anterior and
posterior Lens capsule spikes are seen.
Multiple signals in vitreous baseline
Measurement of Aphakic Eye
• The aphakic echogram consists of
• initial spike
• spike from iris/posterior lens capsule/anterior vitreous face spike
• spike from retina and sclera.
• aphakic type (1532m/sec) is used for measurement
• two gates,
• three gates
Measurement of Pseudophakic Eye
• Manual mode
• Aphakic velocity
• pseudophakic echogram
: IOL reverberations
• Reverberations of PMMA
vs. Acrylic into the
vitreous cavity. Longer chain of
reverberation :
PMMA
Shorter chain
chain of
reverberation :
acrylic
• IOL can be made from PMMA, Silicone or acrylic lenses.
• true AEL is determined by adding appropriate correction factor for
the IOL composition
Potential sources of error with contact
technique
• corneal compression
• fluid meniscus
• misalignment of the sound beam.
• Improper gate position
Potential sources of error with contact
technique
• small air bubbles within the fluid
• improper gate position,
• selection of an inappropriate eye type (sound velocity) setting
TROUBLESHOOTING
• Inadequate Patient Fixation
• Incorrect Sound Velocity Settings
• Intraocular Lesions
• Posterior Staphyloma
• Macular Lesions
• Retinal D e t a c h m e n t
• Vitreous Lesions
• Silicone Oil
• Dense Cataract
• Post Trab
Inadequate patient fixation
• Re explaining the procedure to patient
• Patch other eye to eliminate distraction or if there is strabismus
• Fix at a target with another eye
• If fixation near primary gaze cannot be achieved – examination from
unconventional side position
• Nystagmus and blepharospasm – immersion is preferred
Incorrect Sound Velocity Settings
• Velocity Conversion Equation
• correct measurement when an inappropriate sound velocity is used
during the examination.
• correct value = (Vc/Vm) X measurement
• For example, an aphakic eye was measured using in correct velocity -
1,550 m/see rather than aphakic velocity
• The erroneous axial length reading obtained was 25.0 mm. To
determine the correct (true) axial length measurement:
• 1.532/1.550 m/sec × 25.0 mm= 24.71 mm
Intra ocular lesions
• Patients history
• high myopia
• previous cataract or
vitreoretinal surger
• DR
• ARMD
• B-scan examination – detect
any abnormalities that
affects AXL
• rule of thumb : if no view
during ophthalmoscopy – b
scan prior to biometry
Posterior Staphyloma
• posterior staphyloma is suggested:
• distinct, high retinal spike is difficult to display
• AXL readings : long and inconsistent
• fi a distinct retinal spike and consistent measurements are obtained but the
probe appears to be directed eccentric to the macula (e.g., nasally)
• Immersion a scan is preferred
• Vector Ascan/Bsacan
• Horizontal axial B-scan echogram
Macular lesions
• suspected if
• Difficulty in displaying a steeply rising, retinal spike
• Distance between retinal and scleral spike is more
• If macular lesions are temporary
• Measure macular thickness on OCT/ Bscan and add the thickness to AL
• OR DISTANCE BETWEEN RETINAL AND SCLERAL SPIKE
Retinal Detatchment ( macula off)
• suspected when
• wider than normal distance between the retinal and scleral spikes
• B scan is indicated
• Other eye AXL If no refractive error difference between both eyes
• User adjusted AXL*
• both optical and US biometry is performed
• In optical scans: posterior spike considered
• SNR 2dB or more
• If on optical biometry: multiple spikes – posterior peak correlating to AL is
guided by fellow Eye AL or ipsilateral Ultrasound AL
Rahman, R. et al. (2016) “Accuracy of user-adjusted axial length measurements with optical biometry in eyes having combined phacovitrectomy for
macular-off Rhegmatogenous Retinal Detachment,” Journal of Cataract and Refractive Surgery, 42(7), pp. 1009–1014. Available at:
https://doi.org/10.1016/j.jcrs.2016.04.030.
Silicone Oil
• Cataract surgery after silicone oil injection or combined cataract
surgery and oil removal
• Pre oil inj biometry
• Conversion factor
• 0.64 if 1000 cs silicone used
• 0.71 if 1300 cs silicone used
• Conversion factor can be obtained by : Velocity (oil)/ velocity ( vitreous)
• Silicone oil in eye over estimates AXL so conversion factor is needed
• If above methods not possible
• Other eye biometry if no ref error difference
Biometry of the silicone oil-filled eye1999 Jun;13 ( Pt 3a):319-24. doi: 10.1038/eye.1999.82
• There are presently 2 viscosity of silicon oil in use:
• 1000mPas : 980 m/s
• 5000mPas: 1040 m/s
• If an optical bio meter is not available, the next best approach is
• prior biometry before silicon oil injection
• Or first remove silicon oil and then in place IOL
Post trab*
• AL reduction postoperatively, which became stable nearly 3 months
after the surgery.
• the amount of reduction in AL measured by optical devices is less
than that measured by ultrasonic tools
• Changes in ACD are of small amount and short lived : doesn’t affect
IOL power calculation
• reported changes in AL and keratometry are of sufficient magnitude
to affect refractive prediction of cataract surgery
• better to delay cataract surgery and lens implantation if possible until
AL and keratometry changes stabilize
• preferable to measure biometric parameters using non‐contact
optical biometry method instead of contact ultrasound biometry for
IOL power calculation in such cases.
Esfandiari, H. et al. (2016) “Ocular biometric changes after
trabeculectomy,” Journal of Ophthalmic and Vision Research, 11(3), p. 296.
Available at: https://doi.org/10.4103/2008-322x.188399.
Limitations of Immersion A scan
• After a single immersion A scan , 18-34 samples (53%) grew
organisms from probe/ shell or tubing
• Positive cultures in 32% of immersion shell/probe (11 of 34) and in
31% of infusion tubing samples (10 of 32)
• Shell/ probe should be soaked in alcohol or hydrogen peroxide for at
least 5 min. immersion shell should be allowed to dry completely and
flushed with BSS
VELAZQUEZESTADES, L. et al. (2005) “Microbial contamination of immersion biometry ultrasound equipment,” Ophthalmology, 112(5). Available at:
https://doi.org/10.1016/j.ophtha.2005.01.030.
Method of disinfection
• Following each biometry remove the tubing Kit from the Prager Shell
and discard.
• soak both shell and probe in
• 70% isopropanol or
• solution of 3% hydrogen peroxide for a minimum of 5 minutes.
• Follow CDC Guidelines avoid viral and bacterial patient cross-
contamination.
• CDC Guidelines. wiped clean and then disinfected by:
• (a) a 5- to 10-minute exposure to a fresh solution of 3% hydrogen
peroxide; or (
• (b) a fresh solution containing 5,000 parts per million (mg/L) free available
chlorine--a 1/10 dilution of common household bleach (sodium
hypochlorite);
• (c) 70% ethanol; or
• (d) 70% isopropanol.
• The device should be thoroughly rinsed and dried before patient use.
Good A scan
• Corneal echo seen as tall single spike
• No echoes from aqueous humour
• Ant and post lens capsule produce tall echoes
• Retina – tall sharp rising – no stair casing at origin
• Orbital fat medium to low echoes
• If retinal spike is not followed by multiple small spikes – one is hitting
the optic nerve
• Adequate gain
• ACD : maximum ACD
• 8-10 measurements
• SD < 0.06 ( here we take < 0.03)
AXL length measurement instruments in our
hospital
• Ascan :
• Biomedix echorule pro
• Applanation and immersion
BIOMEDIX ECHORULE 2 BIOMEDIX ECHORULE PRO
Optical biometry
• Optical biometry is highly accurate, noninvasive automated method
for measuring anatomical details of eye.
• First optical biometer – IOL Master 500 – 1999
• Biometric measurements provided
• AL, K, ACD, LT, CCT, PS, WTW
partial coherence interferometry
(PCI) biometry was first created by
Austrian physicists Fercher and Roth
in 1986
1986
In 1999, Carl Zeiss released the IOL
master 500 ( first commercially
accessible optical biometer.)
1999
Currently available optical biometers
• Today’s optical biometers employ one of the following technologies:
• PCI
• OLCR
• Swept-source optical coherence tomography (SS-OCT).
PCI
• Uses 780 nm wavelength IR light wave
• light is reflected by tissue surfaces with different refractive indices
• The ocular distances are then measured using interferometric
techniques.
• Dual Co axial beam interferometer is used
• Example
• IOL master 500
• AL scan
• Pentacam AXL
OLCR
• Video
• A detector detects the interference pattern generated by the
coaxially travelling emitted and reflected light.
• Scanning the reference beam determines the precise spot from
which the light was reflected from within the eye.
• Example
• Lenstar LS900 (Haag-Streit),
• Aladdin (Topcon),
• Galilei G6 (Zeimer).
SS OCT
examples
The IOL Master
700 (Carl Zeiss),
Argos (Movu),
O.A 2000
(Tomey)
Eyestar 900
(Haag-Streit).
Rapid-cycle tunable wavelength laser
source is used
COMPANY PRINCIPLE SOURCE OF LIGHT METHOD OF
MEASURING K
VALUE
IOL MASTER S00 Carl Zeiss, Meditec
AG, Jena , Germany
PCI 780 nm IR laser Reflection based
AL SCAN (NIDEK) Nidek PCI 830 nm diode laser Reflection based
PENTACAM AXL OCULUS
Optikgeräte
GmbH, Germany
PCI 475 nm
monochromatic slit
of blue light
Dual Scheimpflug
rotating camera
with placido disc
imaging
Scanning in opaque
media
Parameters Special features Limitations
IOL MASTER S00 New version 5.0 can
scan in opaque
media
AL, K ACD, WTC GOLD STD
BIOMETER*
Old version can
scan opaque media
AL SCAN (NIDEK) No AL, K ACD, WTW,
pupil size, CCT, ACD
( CCT and ACD
scheimpflug
principles)
3D auto tracking,
auto shoot,
aberrations, torrid
lens assist software
Attached US AXL
and patchy for
dense opacities
Cannot scan in
opaque media
PENTACAM AXL Acquisition success
rate is less **
AL, K ACD, WTW,
pupil size, CCT, ACD
The Gold Standard in
anterior eye segment
tomography
Toric IOL, IOL after LVC,
cataract density grading,
wavefront analysis
Acquisition rate in
denser cataracts is
less
BhattAB,ScheflerAC,FeuerWJ,YooSH,MurrayTG.Comparisonof predictions made by intraocular lens master and ultrasound biometry. Arch Ophthalmol
2008;126:929‐33.
**Henriquez, M.A. et al. (2020) “Effectiveness and agreement of 3 optical biometers in measuring axial length in the eyes of patients with mature
cataracts,” Journal of Cataract and Refractive Surgery, 46(9), pp. 1222–1228. Available at: https://doi.org/10.1097/j.jcrs.0000000000000237.
COMPANY PRINCIPLE SOURCE OF LIGHT METHOD OF
MEASURING K
VALUE
LENSTAR LS 900 HAAG-STREIT AG,
Switzerland
OLCR 820 nm
superluminescent
diode
Placido disc +
optical T module
ALLADIN HW 3.0 TOPCON OLCR 850 nm laser –
penetration in
dense cataracts
Placido disc
GALILEI G6 System vision,
Greece
OLCR 880nm Dual Scheimpflug
and Placido disc
Scanning in opaque
media
Parameters Special features Limitations
LENSTAR LS 900 Poor when
compared to IOL
master 500
AL, K ACD, WTC EYE SUITE IOL:
Comprehensive set
of premium IOL
calculat formulae
Automated
positioning- allows
dynamic eye
tracking of patients.
Poor acquisitions in
dense cataract
ALLADIN HW 3.0 Good AL, K ACD, WTW,
pupil size, CCT, ACD,
LT
Zernicke wavefront
analysis for higher
order aberrations
Mesopic, photo pic
and dynamic
pupillometry
Posterior corneal
surface not
measured
GALILEI G6 System vision,
Greece
AL, K ACD, WTW,
pupil size, CCT, ACD,
LT
3D AC analysis, refractive
surgery,
Ray tracing IOL formulae
Scheimpflug + OCT helpful
in post LVC
Newer IOL formulae
IOL formulae
available are less
compared to
pentacam axl
COMPANY PRINCIPLE SOURCE OF LIGHT METHOD OF
MEASURING K
VALUE
IOL master 700 Carl Zeiss, Meditec
AG, Jena , Germany
SS OCT ( first to use
ss oct)
rapidly tuned laser
with longer
wavelength (1310
nm)
SS OCT with placido
pattern
Argos SS OCT 1060nm From OCT image +
2.2 diameter ring
OA 2000 TOMEY GmbH ,
Nagoya, Japan )
SS OCT Placido disc based
EYE STAR 900 HAAG-STREIT AG,
Switzerland
SSOCT OCT based with
placido pattern
Scanning in opaque
media
Parameters Special features Limitations
IOL master 700 Good K, CCT, ACD, LT,
WTW, PS, AXL,
Telecentric
keratometry
Good in media
opacities
Crystalline lens tilt
or decentration
Fixation check
OA 2000 Fair AL, ACD, LT, CCT,
WTW,
K 3 , 5.5 mm
OA 4000: hAndheld
ultrasound AL,CCT
Scan acquisition
not there in mature
catarcts
EYESTAR 900 Under trial Eye suite software
3D pics of anterior
segment and lens
Hill RBF 3.0
Purpose: To systematically compare and rank
ocular measurements with optical and
ultrasound biometers based on big data.
methods
129 studies
17,181 eyes
12 optical biometers and two ultrasound
biometers (with both contact and
immersion techniques)
• AL and ACD measurements : statistically significant differences
existed btwn contact ultrasound biometry and optical biometers.
• There were no statistically significant differences among 4 ( SS-OCT)
based devices (IOLMaster 700, OA-2000, Argos and ANTERION).
• Ks, Km and CD, statistically significant differences : pentacam AXL was
compared with the IOLMaster 700 and IOLMaster 500.
• There were statistically significant differences for CCT when the OA-
2000 was compared to Pentacam AXL, IOLMaster 700, Lenstar, AL-
Scan and Galilei G6.
• AL and ACD, contact ultrasound biometry obtained lower values
compared to all optical biometers.
• Lowest CCT : OA 2000; highest CCT : Galilei G6
• In relation to Kf, ACD, CCT and CD measurements, results indicate
that there is too much heterogeneity to draw reliable conclusions.
J Cataract Refract Surg 2021; 47:802–814
Copyright Š 2021 The Author(s). Published by
Wolters Kluwer Health, Inc. on behalf of ASCRS
and ESCRS
• Purpose: updated review of the repeatability and re- producibility of
optical biometers based on SS-OCT and their agreement for ocular
dimensions necessary for cat- aract surgery,
• repeatability, reproducibility, and agreement between devices were
analyzed.
• conclusion:
• Differences obtained between some parameters in different studies
has to be analysed and validated to use these values interchangeably
Agreement between Two Swept-Source Optical
Coherence Tomography Biometers and a Partial
Coherence Interferometer
• Purpose :
• agreement between anterion and OA 2000 AND IOL master 500
• Methods
• 51 eyes
• Flat and steep K, ACD, AXL
• Predicted IOL power of each device was compared ( srk/t, Haigis, Barrett
universal 2 and Kane formulas)
Results:
• K values : anterion flatter than other instruments,
but more agreeable with OA 2000
• ACD of anterion and OA 2000 was interchangeable
• Axl high agreement btwn devices
• Iol powers were not interchangeable
ONLY AXL SHOWED GOOD AGREEMENT
BETWEEN THESE DEVICES
Purpose: agreement btwn OA2000 and IOL master
700
103 eyes considered
Except CCT, WTW and PD, IOLMaster 700 and OA-
2000 have excellent agreement on AXL, ACD and
astigmatism power vectors
Intra op wavefront aberrometry
• It uses a system which produces a fringe pattern as wave fronts.
Based on the pattern formed after diffraction through media, sphere,
cylinder and axis is determined
• WaveTec vision systems, Inc : ORAnge , ORA
• Later - Alcon
• Aphakic and pseudophakic measurements
• Confirm and update IOL power, optimise lens postion, corneal
arucate incisions
• Incorporation of AnalyzOR, compares pre-, intra-, and post-op data
and allows surgeons to fine-tune their calculations to improve
outcomes.
• HOLOS
• HOLOS IntraOp by Clarity is the newest available product.
• rapidly rotating micro electro-mechanical system (MEMS) mirror and
quad detector
• measure the magnitude of wavefront displacement.
• 90 measurements per second and has a range from -5D to +16 D
• It attaches to operating microscope
• Advantage is that surgeon doesn’t have change the focus as it has
inbuilt auto focus
Currently available optical biometers
Turczynowska, M. et al. (2016) “Effective ocular biometry and intraocular lens power calculation,” European Ophthalmic Review, 10(02), p. 94. Available
at: https://doi.org/10.17925/eor.2016.10.02.94.
Haigis, W. et al. (2000) “Comparison of immersion ultrasound biometry and partial
coherence interferometry for intraocular lens calculation according to
Haigis,” Graefe's Archive for Clinical and Experimental Ophthalmology, 238(9), pp.
765–773. Available at: https://doi.org/10.1007/s004170000188.
OPTICAL BIOMETER US A SCAN
From corneal vertex to RPE From corneal vertex to ILM
IR Light rays used Ultrasound used
Non contact Contact procedure
Difficult in axial opacities Can be done in axial opacities
Easier in posterior staphylomas ( fovea
may lie along the slope of staphyloma)
Erroneously measured as long axial
length
AXL length measurement instruments in our
hospital
• Ascan :
• Biomedix echorule pro
• Applanation and immersion
• IOL formulae available
• Optical biometer
• OA 2000 (TOMEY GmbH , Nagoya, Japan )
• SSOCT based (product description- dense cataract can also be measured)
• Auto alignment - auto shot
• Placido disc 9 rings
• 5.5 mm cornea is measured
• CCT is measured at 9 points
• K , ACD, LT, PACHYMETRY, pupil size, WTW
• SRKT , Haigis, HOFFER Q, holladay 2, Olsen,
• Oculix, barretts
• IOL models details can be downloaded
• Low reliability mark
• Low reliability data sets have exceeded the majority: !
• When reliability of all data is low: !
• When multiple higher peaks are detected in AXL measurement: !
• When all data returns as error : error
OA 2000 video
Thank you

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a scan.pptx

  • 1. A scan biometry Presenter: Dr. Kshama K IOL FELLOW RJ SANKARA EYE HOSPITAL, NEW PANVEL
  • 2. Ocular Biometry • Word meaning of biometry: measurement of tissues • Components of ocular biometry include • Measurement of axial length • Measurement of corneal dioptric power • IOL formulae and IOL power calculations • The key issue faced in selecting an accurate power IOL is obtaining accurate measurements and selection of optimal IOL calculation formula.
  • 3. Axial length measurements • Different methods to measure the axial length of the eye ball • Ultrasound • A scan : applanation and immersion a scan • B scan • Optical Biometer
  • 4. Ultrasound A scan • One dimensional scan in which echoes are represented as vertical spikes from baseline • 1mm error in AXL – 2.35D error • Axial length has to be repeated if difference between 2 eyes is 0.3 mm or if there is difference of 0.2 mm in consequtive readings
  • 5. • Time required for sound pulse to travel from probe to interface is noted • Velocity of sound in different medium is known • 1620 m/s in cornea • 1641 m/s in lens • 1629 in dense cataract • 1630 m/s sclera • 1532 m/s in aqueous and vitreous • 986 m/s in silicone oil • 2718 m/s PMMA • Knowing time and velocity distance between two spikes gives the length / AXL
  • 6. Ultrasound waves have frequency greater than 20khz (20,000 oscillations/sec),inaudible to human ears. Audible Sound Waves : 20-20,000 Hz
  • 7. • Diagnostic ophthalmology utilizes frequency of 8-10 Mhz (1Mhz=1,000,000 cycles/sec) • High frequencies produces short wavelength <0.2mm, which allows resolution of minute ocular structure. • Lower frequency produce longer wavelength
  • 8. Principles of Ultrasound • Reflectivity • When sound wave travels part of the sound is reflected from the interfaces into the probe -echo. • Greater the density difference at the interface, stronger the echo • stronger echo : higher the spike in A-scan and brighter the dots in B-scan.
  • 9. • Velocity • Angle of incidence perpendicular angle of incidence will be equal to the angle of reflection oblique part of the echo is reflected away from the p tip weaker echo than the perpendicular sound incidence Less energy is returned displayed image is compromised.
  • 10. Probes • first generation of contact biometers: water-filled probes with a soft membranous tip. • filled with distilled water, • small air bubbles trapped : erroneous AEL • Newer biometers : solid probes • Applanation/ contact vs immersion probes • 10-12 MHz • Focused vs non focused beam
  • 11.
  • 14. Instrument Settings • (1) measurement mode, • (2) eye type, • (3) position of electronic gates or cursors, and • (4) gain.
  • 15. Measurement Mode (Automatic vs. Manual) Automatic Measurement Mode In automatic continuous measurement mode the software uses standard settings for gain, gates and detection threshold. Beep is heard after each reading. Beep indicates valid scan , and momentarily freezes the scan pattern on the screen. Rapid 10 reading are taken continuously . Used for most of the cooperative patients with normal cataract eyes.
  • 16. Manual Measurement Mode The A-scan will recognise the valid pattern freeze the amplitude pattern for 2 seconds after which the screen is reset. if the biometrist decides to retain the reading, press the freeze button.
  • 17. Eye type ( Sound velocity) • velocity setting on the instrument should always be checked prior to beginning the examination. • phakic eye: • Avg sound velocity setting : 1550 m/s • Assumes constant relationship btwn lens thickness and the depth of the anterior chamber. • sufficient for measuring the normal phakic eye , small errors in thick and thin lenses, long or short eyes • Measure components separately and add the AXL • VELOCITY CONVERSION EQUATION can be used if uncorrect velocity is used
  • 18. Gates • Electronic calipers that measure between two points • Auto mode : gate position decided by the machine • Manual mode : gate position decided by operator
  • 19. Gain setting • degree of echo amplification in an ultrasound system. • beginning of an examination, the gain must be high – align grossly along the visual axis to see overall appearance of echo gram • Reduce gain to medium level – improve resolution of spikes • High gain – artefact spike is tall and confused with Retinal spike – short AXL • Low gain – small retinal spike – adjacent scleral spike might be misread as retinal spike – longer AXL
  • 20.
  • 21. EXAMINATION PROCEDURES FOR A-SCAN BIOMETRY • history and explaining the examination to the patient. • Patient Positioning • Applanation : chin rest • Hand held contact : sitting/reclining • Immersion : supine / recliner/ supine with chin elevation • Silicone filled eyes : sitting with no head tilting back • instrument settings adjusted • both eyes measured whenever possible • Actual measurement
  • 22. Contact Technique • probe placed gently on the center of the cornea • no ointment or excess fluid : erroneously high AXL • Steps to minimise corneal compression • If manual mode : • measurement taken as soon as the probe touches cornea. • Probe is removed before taking subsequent measurements: intermittent probe contact • Pt asked to blink • Each reading to see ACD • 3 high quality readings
  • 23. Applanation method. • Pressure sensitive probe can be used • Joystick is retracted as far away as possible • joystick is then advanced until the probe gently touches the center of thecornea.
  • 24. Handheld method • cornea is more easily compressed with this technique than with the applanation method. • When a pressure sensitive sleeve is not employed, the patient should be reclined. • When pt seated upright , examiner should observe cornea from side to minimise compression
  • 25. Immersion Technique • employs a small water bath – hence corneal compression avoided • separate corneal spike (not present in the contact method) -facilitate alignment of the sound beam along visual axis. • Avoid air bubbles Ossoinig Hansen
  • 27. Prager shell An advantage of this shell is that it allows the immersion ex- amination to be performed with the patient sitting upright rather than reclined.
  • 28. • examiner immerses the probe into the fluid just until an echogram si displayed. • tip located approximately 3⁄8inch from the bottom of the shell. • balanced salt solution • double-peaked corneal spike and single-peaked spikes from the anterior and posterior lens surfaces, retina, and sclera. • 3 high quality reading
  • 29. fluid for immersion • If Hansen scleral shells are used : CMC 1% • If prager shell: BSS (slightly hypotonic) or CMC 0.5% • goniosol: hypromellose 40ml • Dacriose: 60ml • Isotonic, Buffered Solution of Purified Water, Sodium Phosphate, Potassium Chloride, Sodium Hydroxide, Edetate Disodium and Sodium Chloride, Preserved with Benzalkonium Chloride 0.1 mg/ml.
  • 30. Measurement of Phakic Eye • Phakic setting is used • Phakic setting works in 3 way depending on the instrument • In extremely dense cataracts : • Sound attenuation : weakening of retinal spike – prolonged measuring time • Manual mode / dense cataract mode to be used
  • 31. Measurement of Phakic Eye • 3WAYS • 2 gates • between initial spike and retinal spike • Preset avg sound velocity – 1550 m/sec • 4 gates • AC depth measured using 1532 m/s • LENS thickness using 1641 m/s • vitreous cavity using 1532 m/s • ACD+LT+VL = AXL • Aphakic sound velocity setting of 1532 m/s • Uses 2 gates • AXL measured + CALF (0.32 mm)CALF depends on the lens thickness for the age • CALF changes with density of cataract • Avg CALF value for most cataract pts is 0.32
  • 32. Multiple signals • Between ant n posterior lens capsule • due to interfaces within a cataractous lens • In vitreous baseline (reverberations) : • These decrease with decrease in gain • caution should be exercised in using the automatic mode when multiple signals are present: the instrument may place one or more gates on the wrong spikes, resulting in erroneous measurement
  • 33.
  • 34. A scan of a moderately dense Cataract:. Spikes between anterior and posterior Lens capsule spikes are seen.
  • 35. Multiple signals in vitreous baseline
  • 36.
  • 37. Measurement of Aphakic Eye • The aphakic echogram consists of • initial spike • spike from iris/posterior lens capsule/anterior vitreous face spike • spike from retina and sclera. • aphakic type (1532m/sec) is used for measurement • two gates, • three gates
  • 38. Measurement of Pseudophakic Eye • Manual mode • Aphakic velocity • pseudophakic echogram : IOL reverberations • Reverberations of PMMA vs. Acrylic into the vitreous cavity. Longer chain of reverberation : PMMA Shorter chain chain of reverberation : acrylic
  • 39. • IOL can be made from PMMA, Silicone or acrylic lenses. • true AEL is determined by adding appropriate correction factor for the IOL composition
  • 40. Potential sources of error with contact technique • corneal compression • fluid meniscus • misalignment of the sound beam. • Improper gate position
  • 41. Potential sources of error with contact technique • small air bubbles within the fluid • improper gate position, • selection of an inappropriate eye type (sound velocity) setting
  • 42. TROUBLESHOOTING • Inadequate Patient Fixation • Incorrect Sound Velocity Settings • Intraocular Lesions • Posterior Staphyloma • Macular Lesions • Retinal D e t a c h m e n t • Vitreous Lesions • Silicone Oil • Dense Cataract • Post Trab
  • 43. Inadequate patient fixation • Re explaining the procedure to patient • Patch other eye to eliminate distraction or if there is strabismus • Fix at a target with another eye • If fixation near primary gaze cannot be achieved – examination from unconventional side position • Nystagmus and blepharospasm – immersion is preferred
  • 44. Incorrect Sound Velocity Settings • Velocity Conversion Equation • correct measurement when an inappropriate sound velocity is used during the examination. • correct value = (Vc/Vm) X measurement • For example, an aphakic eye was measured using in correct velocity - 1,550 m/see rather than aphakic velocity • The erroneous axial length reading obtained was 25.0 mm. To determine the correct (true) axial length measurement: • 1.532/1.550 m/sec × 25.0 mm= 24.71 mm
  • 45. Intra ocular lesions • Patients history • high myopia • previous cataract or vitreoretinal surger • DR • ARMD • B-scan examination – detect any abnormalities that affects AXL • rule of thumb : if no view during ophthalmoscopy – b scan prior to biometry
  • 46. Posterior Staphyloma • posterior staphyloma is suggested: • distinct, high retinal spike is difficult to display • AXL readings : long and inconsistent • fi a distinct retinal spike and consistent measurements are obtained but the probe appears to be directed eccentric to the macula (e.g., nasally) • Immersion a scan is preferred • Vector Ascan/Bsacan • Horizontal axial B-scan echogram
  • 47.
  • 48. Macular lesions • suspected if • Difficulty in displaying a steeply rising, retinal spike • Distance between retinal and scleral spike is more • If macular lesions are temporary • Measure macular thickness on OCT/ Bscan and add the thickness to AL • OR DISTANCE BETWEEN RETINAL AND SCLERAL SPIKE
  • 49. Retinal Detatchment ( macula off) • suspected when • wider than normal distance between the retinal and scleral spikes • B scan is indicated • Other eye AXL If no refractive error difference between both eyes • User adjusted AXL* • both optical and US biometry is performed • In optical scans: posterior spike considered • SNR 2dB or more • If on optical biometry: multiple spikes – posterior peak correlating to AL is guided by fellow Eye AL or ipsilateral Ultrasound AL Rahman, R. et al. (2016) “Accuracy of user-adjusted axial length measurements with optical biometry in eyes having combined phacovitrectomy for macular-off Rhegmatogenous Retinal Detachment,” Journal of Cataract and Refractive Surgery, 42(7), pp. 1009–1014. Available at: https://doi.org/10.1016/j.jcrs.2016.04.030.
  • 50. Silicone Oil • Cataract surgery after silicone oil injection or combined cataract surgery and oil removal • Pre oil inj biometry • Conversion factor • 0.64 if 1000 cs silicone used • 0.71 if 1300 cs silicone used • Conversion factor can be obtained by : Velocity (oil)/ velocity ( vitreous) • Silicone oil in eye over estimates AXL so conversion factor is needed • If above methods not possible • Other eye biometry if no ref error difference Biometry of the silicone oil-filled eye1999 Jun;13 ( Pt 3a):319-24. doi: 10.1038/eye.1999.82
  • 51. • There are presently 2 viscosity of silicon oil in use: • 1000mPas : 980 m/s • 5000mPas: 1040 m/s • If an optical bio meter is not available, the next best approach is • prior biometry before silicon oil injection • Or first remove silicon oil and then in place IOL
  • 52. Post trab* • AL reduction postoperatively, which became stable nearly 3 months after the surgery. • the amount of reduction in AL measured by optical devices is less than that measured by ultrasonic tools • Changes in ACD are of small amount and short lived : doesn’t affect IOL power calculation • reported changes in AL and keratometry are of sufficient magnitude to affect refractive prediction of cataract surgery
  • 53. • better to delay cataract surgery and lens implantation if possible until AL and keratometry changes stabilize • preferable to measure biometric parameters using non‐contact optical biometry method instead of contact ultrasound biometry for IOL power calculation in such cases. Esfandiari, H. et al. (2016) “Ocular biometric changes after trabeculectomy,” Journal of Ophthalmic and Vision Research, 11(3), p. 296. Available at: https://doi.org/10.4103/2008-322x.188399.
  • 54. Limitations of Immersion A scan • After a single immersion A scan , 18-34 samples (53%) grew organisms from probe/ shell or tubing • Positive cultures in 32% of immersion shell/probe (11 of 34) and in 31% of infusion tubing samples (10 of 32) • Shell/ probe should be soaked in alcohol or hydrogen peroxide for at least 5 min. immersion shell should be allowed to dry completely and flushed with BSS VELAZQUEZESTADES, L. et al. (2005) “Microbial contamination of immersion biometry ultrasound equipment,” Ophthalmology, 112(5). Available at: https://doi.org/10.1016/j.ophtha.2005.01.030.
  • 55. Method of disinfection • Following each biometry remove the tubing Kit from the Prager Shell and discard. • soak both shell and probe in • 70% isopropanol or • solution of 3% hydrogen peroxide for a minimum of 5 minutes. • Follow CDC Guidelines avoid viral and bacterial patient cross- contamination. • CDC Guidelines. wiped clean and then disinfected by: • (a) a 5- to 10-minute exposure to a fresh solution of 3% hydrogen peroxide; or ( • (b) a fresh solution containing 5,000 parts per million (mg/L) free available chlorine--a 1/10 dilution of common household bleach (sodium hypochlorite); • (c) 70% ethanol; or • (d) 70% isopropanol. • The device should be thoroughly rinsed and dried before patient use.
  • 56. Good A scan • Corneal echo seen as tall single spike • No echoes from aqueous humour • Ant and post lens capsule produce tall echoes • Retina – tall sharp rising – no stair casing at origin • Orbital fat medium to low echoes • If retinal spike is not followed by multiple small spikes – one is hitting the optic nerve
  • 57. • Adequate gain • ACD : maximum ACD • 8-10 measurements • SD < 0.06 ( here we take < 0.03)
  • 58.
  • 59. AXL length measurement instruments in our hospital • Ascan : • Biomedix echorule pro • Applanation and immersion BIOMEDIX ECHORULE 2 BIOMEDIX ECHORULE PRO
  • 60. Optical biometry • Optical biometry is highly accurate, noninvasive automated method for measuring anatomical details of eye. • First optical biometer – IOL Master 500 – 1999 • Biometric measurements provided • AL, K, ACD, LT, CCT, PS, WTW
  • 61. partial coherence interferometry (PCI) biometry was first created by Austrian physicists Fercher and Roth in 1986 1986 In 1999, Carl Zeiss released the IOL master 500 ( first commercially accessible optical biometer.) 1999
  • 62. Currently available optical biometers • Today’s optical biometers employ one of the following technologies: • PCI • OLCR • Swept-source optical coherence tomography (SS-OCT).
  • 63. PCI • Uses 780 nm wavelength IR light wave • light is reflected by tissue surfaces with different refractive indices • The ocular distances are then measured using interferometric techniques. • Dual Co axial beam interferometer is used
  • 64. • Example • IOL master 500 • AL scan • Pentacam AXL
  • 65. OLCR • Video • A detector detects the interference pattern generated by the coaxially travelling emitted and reflected light. • Scanning the reference beam determines the precise spot from which the light was reflected from within the eye.
  • 66.
  • 67. • Example • Lenstar LS900 (Haag-Streit), • Aladdin (Topcon), • Galilei G6 (Zeimer).
  • 68. SS OCT examples The IOL Master 700 (Carl Zeiss), Argos (Movu), O.A 2000 (Tomey) Eyestar 900 (Haag-Streit). Rapid-cycle tunable wavelength laser source is used
  • 69. COMPANY PRINCIPLE SOURCE OF LIGHT METHOD OF MEASURING K VALUE IOL MASTER S00 Carl Zeiss, Meditec AG, Jena , Germany PCI 780 nm IR laser Reflection based AL SCAN (NIDEK) Nidek PCI 830 nm diode laser Reflection based PENTACAM AXL OCULUS Optikgeräte GmbH, Germany PCI 475 nm monochromatic slit of blue light Dual Scheimpflug rotating camera with placido disc imaging
  • 70. Scanning in opaque media Parameters Special features Limitations IOL MASTER S00 New version 5.0 can scan in opaque media AL, K ACD, WTC GOLD STD BIOMETER* Old version can scan opaque media AL SCAN (NIDEK) No AL, K ACD, WTW, pupil size, CCT, ACD ( CCT and ACD scheimpflug principles) 3D auto tracking, auto shoot, aberrations, torrid lens assist software Attached US AXL and patchy for dense opacities Cannot scan in opaque media PENTACAM AXL Acquisition success rate is less ** AL, K ACD, WTW, pupil size, CCT, ACD The Gold Standard in anterior eye segment tomography Toric IOL, IOL after LVC, cataract density grading, wavefront analysis Acquisition rate in denser cataracts is less BhattAB,ScheflerAC,FeuerWJ,YooSH,MurrayTG.Comparisonof predictions made by intraocular lens master and ultrasound biometry. Arch Ophthalmol 2008;126:929‐33. **Henriquez, M.A. et al. (2020) “Effectiveness and agreement of 3 optical biometers in measuring axial length in the eyes of patients with mature cataracts,” Journal of Cataract and Refractive Surgery, 46(9), pp. 1222–1228. Available at: https://doi.org/10.1097/j.jcrs.0000000000000237.
  • 71. COMPANY PRINCIPLE SOURCE OF LIGHT METHOD OF MEASURING K VALUE LENSTAR LS 900 HAAG-STREIT AG, Switzerland OLCR 820 nm superluminescent diode Placido disc + optical T module ALLADIN HW 3.0 TOPCON OLCR 850 nm laser – penetration in dense cataracts Placido disc GALILEI G6 System vision, Greece OLCR 880nm Dual Scheimpflug and Placido disc
  • 72. Scanning in opaque media Parameters Special features Limitations LENSTAR LS 900 Poor when compared to IOL master 500 AL, K ACD, WTC EYE SUITE IOL: Comprehensive set of premium IOL calculat formulae Automated positioning- allows dynamic eye tracking of patients. Poor acquisitions in dense cataract ALLADIN HW 3.0 Good AL, K ACD, WTW, pupil size, CCT, ACD, LT Zernicke wavefront analysis for higher order aberrations Mesopic, photo pic and dynamic pupillometry Posterior corneal surface not measured GALILEI G6 System vision, Greece AL, K ACD, WTW, pupil size, CCT, ACD, LT 3D AC analysis, refractive surgery, Ray tracing IOL formulae Scheimpflug + OCT helpful in post LVC Newer IOL formulae IOL formulae available are less compared to pentacam axl
  • 73. COMPANY PRINCIPLE SOURCE OF LIGHT METHOD OF MEASURING K VALUE IOL master 700 Carl Zeiss, Meditec AG, Jena , Germany SS OCT ( first to use ss oct) rapidly tuned laser with longer wavelength (1310 nm) SS OCT with placido pattern Argos SS OCT 1060nm From OCT image + 2.2 diameter ring OA 2000 TOMEY GmbH , Nagoya, Japan ) SS OCT Placido disc based EYE STAR 900 HAAG-STREIT AG, Switzerland SSOCT OCT based with placido pattern
  • 74. Scanning in opaque media Parameters Special features Limitations IOL master 700 Good K, CCT, ACD, LT, WTW, PS, AXL, Telecentric keratometry Good in media opacities Crystalline lens tilt or decentration Fixation check OA 2000 Fair AL, ACD, LT, CCT, WTW, K 3 , 5.5 mm OA 4000: hAndheld ultrasound AL,CCT Scan acquisition not there in mature catarcts EYESTAR 900 Under trial Eye suite software 3D pics of anterior segment and lens Hill RBF 3.0
  • 75.
  • 76. Purpose: To systematically compare and rank ocular measurements with optical and ultrasound biometers based on big data. methods 129 studies 17,181 eyes 12 optical biometers and two ultrasound biometers (with both contact and immersion techniques)
  • 77. • AL and ACD measurements : statistically significant differences existed btwn contact ultrasound biometry and optical biometers. • There were no statistically significant differences among 4 ( SS-OCT) based devices (IOLMaster 700, OA-2000, Argos and ANTERION). • Ks, Km and CD, statistically significant differences : pentacam AXL was compared with the IOLMaster 700 and IOLMaster 500. • There were statistically significant differences for CCT when the OA- 2000 was compared to Pentacam AXL, IOLMaster 700, Lenstar, AL- Scan and Galilei G6.
  • 78. • AL and ACD, contact ultrasound biometry obtained lower values compared to all optical biometers. • Lowest CCT : OA 2000; highest CCT : Galilei G6 • In relation to Kf, ACD, CCT and CD measurements, results indicate that there is too much heterogeneity to draw reliable conclusions.
  • 79. J Cataract Refract Surg 2021; 47:802–814 Copyright Š 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of ASCRS and ESCRS
  • 80. • Purpose: updated review of the repeatability and re- producibility of optical biometers based on SS-OCT and their agreement for ocular dimensions necessary for cat- aract surgery, • repeatability, reproducibility, and agreement between devices were analyzed. • conclusion: • Differences obtained between some parameters in different studies has to be analysed and validated to use these values interchangeably
  • 81. Agreement between Two Swept-Source Optical Coherence Tomography Biometers and a Partial Coherence Interferometer
  • 82. • Purpose : • agreement between anterion and OA 2000 AND IOL master 500 • Methods • 51 eyes • Flat and steep K, ACD, AXL • Predicted IOL power of each device was compared ( srk/t, Haigis, Barrett universal 2 and Kane formulas)
  • 83. Results: • K values : anterion flatter than other instruments, but more agreeable with OA 2000 • ACD of anterion and OA 2000 was interchangeable • Axl high agreement btwn devices • Iol powers were not interchangeable ONLY AXL SHOWED GOOD AGREEMENT BETWEEN THESE DEVICES
  • 84.
  • 85. Purpose: agreement btwn OA2000 and IOL master 700 103 eyes considered Except CCT, WTW and PD, IOLMaster 700 and OA- 2000 have excellent agreement on AXL, ACD and astigmatism power vectors
  • 86. Intra op wavefront aberrometry • It uses a system which produces a fringe pattern as wave fronts. Based on the pattern formed after diffraction through media, sphere, cylinder and axis is determined • WaveTec vision systems, Inc : ORAnge , ORA • Later - Alcon
  • 87. • Aphakic and pseudophakic measurements • Confirm and update IOL power, optimise lens postion, corneal arucate incisions • Incorporation of AnalyzOR, compares pre-, intra-, and post-op data and allows surgeons to fine-tune their calculations to improve outcomes.
  • 88. • HOLOS • HOLOS IntraOp by Clarity is the newest available product. • rapidly rotating micro electro-mechanical system (MEMS) mirror and quad detector • measure the magnitude of wavefront displacement.
  • 89. • 90 measurements per second and has a range from -5D to +16 D • It attaches to operating microscope • Advantage is that surgeon doesn’t have change the focus as it has inbuilt auto focus
  • 90. Currently available optical biometers Turczynowska, M. et al. (2016) “Effective ocular biometry and intraocular lens power calculation,” European Ophthalmic Review, 10(02), p. 94. Available at: https://doi.org/10.17925/eor.2016.10.02.94.
  • 91. Haigis, W. et al. (2000) “Comparison of immersion ultrasound biometry and partial coherence interferometry for intraocular lens calculation according to Haigis,” Graefe's Archive for Clinical and Experimental Ophthalmology, 238(9), pp. 765–773. Available at: https://doi.org/10.1007/s004170000188. OPTICAL BIOMETER US A SCAN From corneal vertex to RPE From corneal vertex to ILM IR Light rays used Ultrasound used Non contact Contact procedure Difficult in axial opacities Can be done in axial opacities Easier in posterior staphylomas ( fovea may lie along the slope of staphyloma) Erroneously measured as long axial length
  • 92. AXL length measurement instruments in our hospital • Ascan : • Biomedix echorule pro • Applanation and immersion • IOL formulae available
  • 93. • Optical biometer • OA 2000 (TOMEY GmbH , Nagoya, Japan ) • SSOCT based (product description- dense cataract can also be measured) • Auto alignment - auto shot • Placido disc 9 rings • 5.5 mm cornea is measured • CCT is measured at 9 points • K , ACD, LT, PACHYMETRY, pupil size, WTW • SRKT , Haigis, HOFFER Q, holladay 2, Olsen, • Oculix, barretts • IOL models details can be downloaded
  • 94. • Low reliability mark • Low reliability data sets have exceeded the majority: ! • When reliability of all data is low: ! • When multiple higher peaks are detected in AXL measurement: ! • When all data returns as error : error
  • 96.
  • 97.

Editor's Notes

  1. Sound waves are generated at frequency more than 20000 hz (20kHz) A scan = time amplitude scan = amplitude scan – 10 MHz B scan – 12 MHz B scan = brightness scan UBM – 35-100Mhz – high resolution but depth of penetration is 4-5 mm
  2. 1476 m/s in silicon IOL Other uses of A scan Intra ocular tumor progression / regression Detect IOFB Extent of intra ocular damage in trauma Ultrasonic pachymetry
  3. For dense cataract velocity conversion equation can b used
  4. External multiple signals : reverberations : repeated back and forth movement of sound btween the transducer (probe tip) and an acoustic interface crystalline lens intraocular lens foreign body air bubble Sclera Internal multiple signals reverberations (ringing) within certain types of foreign bodies. spherical foreign body: small bubble non-spherical foreign body:
  5. If silicon oil is to remain for extended period after cataract surgery adjustment to iol must be made PMMA lens is first choice , silicone is avoided Plano convex lens with Plano facing vitreous Additional power : +3.0 to +3.5
  6. Increase gain: dense cataracts, opacities, high myopia Decrease gain in: silicone oil, PSK
  7. IOL master 500 Carl Zeiss AL scan from Nidek Pentacam AXL from Oculus Light from a low coherence light source is split at 1 and reflected by mirrors 1 n 2 and merge back at one To produce a coaxial dual beam The coaxial dual beam enters eye and there are 2 reflections at cornea and retina. And light travels back When 2d is equal to 2 OL If the delay of these two light beam components – produced by the interfer- ometer – equals an intraocular distance within the coherence length of the light source, an interference signal (called PCI signal) is detected, THEN PATTERN
  8. Current optical biometers are based on different optical technologies, including partial coherence interferometry, optical low coherence reflectometry, optical low coherence interferometry, and, most recently, swept-source optical coherence tomography (SS-OCT). SS-OCT has several advantages over other technologies used in ocular biometry, such as deeper light penetration or long-range OCT imaging of posterior segment structures.6 This may be useful (easier and more accurate) for determination of biometric parameters in patients with cataract because of the use of a large wavelength in the light source compared with other optical technologies that use shorter wavelengths.6.
  9. TD OCR- 400 scans per second, 30 deg spacing so pathologies can be missed. SD oct – 20000 – 40000 scans / s SS OCT – 1 lakh to 4 lakhs scans / s EDI increasing of wavelength Wavelength Td oct : 810 Sd oct 800- 870 nm Ss oct : 1052
  10. The multidot-keratometer comprises 18 points, which are arranged on three rings radially to pivot the instrument.
  11. Different wavelength, different density of cataracts Recommend more studies in future which considers this subgroup
  12. The focal point of HOLOS surgery is retained at the iris plane or wherever the surgeon is working. The surgeon does not have to readjust the scope to achieve qualified readings because the data are constantly generated and certified. To get a reading, you do not have to alter the focus, switch off the microscope light or raise the system to a set height above the cornea as you do with ORA.[46] The focus of the HOLOS[49] system corresponds to the focus in the microscope. This improves your efficiency in OR.2
  13. Ray tracing is a method for calculating the path of a single ray of light through a given optical system Ray tracing technique adv : post op ACD can be more accurately predicted and hence ELP can be derived more accurately when compared to Gaussian optics Because in comparison with Gaussian optics ray tracing considers cornea as it is I.e., both ant and posterior surface. So ACD = from posterior surface of cornea to anterior surface of IOL Olsen formula uses ray tracing 3rd gen formulae uses Gaussian optics.