As per Kidney Sujit Chatterjee Hiranandani Hospital Kidney, failure occurs when kidneys can’t do their job well, causing significant health issues. The kidneys play a crucial role in cleaning your blood and maintaining balance in the body. However, they can become weak, leading to difficulties in getting rid of waste and managing essential functions. Various reasons, such as frequent illness (especially with diabetes or high blood pressure), taking specific medicines, having infections, or family genes, can contribute to kidney failure.