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Water soluble Vitmin D3
1.
2. Market
This market is projected
to reach about $2.5
Billion by 2020 at a
CAGR of 11%.
3. The market is over saturated with Vitamin D
supplements that aren’t doing all that much
for us. Why? Poor bioavailability!
4. • 100% Bioavailable Formulation As;
• Dry powder, one capsules a day to keep you Fit.
• The 1st product of its kind in the market
5. Cholesterol
from diet
7 dehydrocholesterol in the skin
Sunlight converts 7-
dehydrocholesterol to
previtamin D3
Cholecalciferol
(Previtamin D3)
The liver converts previtamin D
to 25-hydroxyvitamin D which
appears in circulation.
25-hydroxyvitamin D
(circulating form)
The kidneys and other
tissues convert it to an
active form of 1,25-
dihydroxyvitamin D
1,25-dihydroxyvitamin D
(active form)
6. – Regulating calcium and
phosphate metabolism for
bone health,
– Autoimmune diseases,
– Atopic dermatitis,
– Cardiovascular disease,
– Chronic respiratory
diseases
– Crohn’s disease and
Inflammatory bowel
disease,
– Diabetes, type 1 and type 2
– Kidney disease,
– Osteoarthritis,
– Periodontal disease,
– Rheumatoid arthritis,
– Skin disorders,
– Some cancers,
– Infectious disease,
– Schizophrenia
1,25-dihydroxyvitamin D plays an important role in:
7. Recommended Dietary Allowances (RDAs) for Vitamin D
Age Male Female Pregnancy Lactation
0–12 months* 400 IU
(10 mcg)
400 IU
(10 mcg)
1–13 years 600 IU
(15 mcg)
600 IU
(15 mcg)
14–18 years 600 IU
(15 mcg)
600 IU
(15 mcg)
600 IU
(15 mcg)
600 IU
(15 mcg)
19–50 years 600 IU
(15 mcg)
600 IU
(15 mcg)
600 IU
(15 mcg)
600 IU
(15 mcg)
51–70 years 600 IU
(15 mcg)
600 IU
(15 mcg)
>70 years 800 IU
(20 mcg)
800 IU
(20 mcg)
Institute of Medicine, and Endocrine Society Recommended Vitamin D intake (2011)* Adequate Intake (AI)
8. Food
IUs per
serving Percent DV
Cod liver oil, 1 tablespoon 1,360 340
Swordfish, cooked, 3 ounces 566 142
Salmon (sockeye), cooked, 3 ounces 447 112
Tuna fish, canned in water, drained, 3 ounces 154 39
Orange juice fortified with vitamin D, 1 cup 137 34
Milk, nonfat, reduced fat, and whole, vitamin D-fortified, 1 cup 115-124 29-31
Yogurt, fortified with 20% of the DV for vitamin D, 6 ounces 80 20
Margarine, fortified, 1 tablespoon 60 15
Sardines, canned in oil, drained, 2 sardines 46 12
Liver, beef, cooked, 3 ounces 42 11
Egg, 1 large (vitamin D is found in yolk) 41 10
Ready-to-eat cereal, fortified with 10% of the DV for vitamin D, 1 cup 40 10
nih.gov
9. • What it'll do for you: Vitamin D's main job is to increase the flow of calcium into the bloodstream by promoting the absorption of calcium and
phosphates from food in the intestines and the reabsorption of calcium in the kidneys. That means vitamin D plays a key role in maintaining strong
bones and protecting against osteoporosis. Experts and recent studies say Vitamin D plays a role in a few other positive effects as well:
• Improves longevity
Studies of more than 57,000 subjects found that people taking supplements with at least at least 500 IUS of vitamin D were seven percent less likely
to die than those who didn't take daily supplements. Researchers credited this to the protective effect of vitamin D against diseases—including
cancer—and the vitamin's possible boost of blood vessel efficiency and the immune system.
• Lowers the risk of heart disease
Researchers at the Intermountain Medical Center Heart Institute in Murray, Utah, studied 9,400 patients whose blood tests revealed low vitamin D
levels during a routine trip to the doctor. The patients who raised their vitamin D levels by their next follow-up were 33 percent less likely to have a
heart attack and 20 percent less likely to develop heart failure compared to their counterparts who did not increase vitamin D levels.
• Prevents high blood pressure
It has been noted that blood pressure is often elevated during the winter—when the body is producing lower levels of vitamin D through sunlight.
This suggests a possible direct correlation between higher levels of vitamin and low blood pressure levels.
• May lower risk of certain cancers
European researchers have found that people with higher blood levels of vitamin D have a much lower risk of colon cancer. In one study, doctors
examined the lifestyles of more than 520,000 patients between 1992 and 1998. The results, which were reported in January of this year, found that
those with the highest blood levels of vitamin D had a nearly 40 percent decrease in colorectal cancer compared to those with the lowest levels.
• Helps fight against influenza
After a four-month long study of Japanese schoolchildren, researchers found that taking vitamin D supplements during the winter and early spring
help prevent seasonal flu and asthma attacks. There was no consideration of the effects of the supplements on adults but other studies have found
that vitamin D dramatically stimulates natural killer cells and play a major role in protecting the lungs from infection.
• Reduces muscle pain
Limited research has reported vitamin D deficiency in patients with low-back pain, and that supplementation may help to reduce the pain.
Supplements may also help with chronic fatigue, headaches and other types of pain.
• Suggested intake: The recommended intake of vitamin D for males up to 50 years old is 200 IU (or 5 micrograms) and increases 200 IUs every 20
additional years. "The average man seems to be deficient in many vitamins, especially vitamin D," says registered dietitian and American Dietetic
Association spokesperson Jim White. Not surprisingly, he recommends a varied diet. White adds that the richest sources of vitamin D are egg yolks,
some types of fish (salmon, tuna and mackerel), butter, liver and cheese. "But it is important to stay within you calorie needs," White adds.
• It's been reported that 10 to 15 minutes of sunshine three times a week is enough to prevent deficiencies. However, many people living in sunny
climates still do not make enough vitamin D and need more from their diet or supplementation. "Individuals with limited sun exposure need to
include good sources of vitamin D in their diet or take a supplement," White adds.
• Those who take a multivitamin should note that most pills do include vitamin D, usually in strengths from 50 IU to 1,000 IU. White says supplements
are okay to take but that you should consider the IUs you're already getting from your diet and work with your doctor to find a supplement that
supplies the right amount of IU's for your diet or lifestyle.
• How important is vitamin D? Deficiencies have now been linked to types of cancers, heart disease, depression, weight gain, muscle pain and other
maladies. "Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak," explains White. "In
adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. This is very rare in men but has
been seen in extreme cases."
10.
11. (Solubilized Vitamin D3)
SMART-D3
Highly bio-available
Nutritional Information ( Approximate values)
Each serving/one capsule contains;
Energy 6.14 Kcal
Carbohydrate 0.11g
Protein 0.18g
Fat 0.55g
Cholecalciferol 2000IU
Other ingredients: Magnesium,starch,
microcrystalline cellulose, Turmeric
Uses : Dietary supplement, one capsule
Daily. Store at dry cool place
Marketed By;
AyurvedicDoc.com
Baton Rouge, LA
USA
Highly Bio-available product
Not for medicinal use
Caution : Do not use if allergic to
Any content
No artificial color used
MFG Date :
BEST USE WITHIN 24 MONTHS
Manufactured in association with
Meda Biotech using
Hybrid Nanoenginring
30
Capsules
SMART-D3
(Solubilized Vitamin D3)
Highly bio-available
Nutritional Information ( Approximate values)
Each serving/one capsule contains;
Energy 6.14 Kcal
Carbohydrate 0.11g
Protein 0.18g
Fat 0.55g
Cholecalciferol 2000IU
Other ingredients: Magnesium,starch,
microcrystalline cellulose, Turmeric
Uses : Dietary supplement, one capsule
Daily. Store at dry cool place
Marketed By;
AyurvedicDoc.com
Baton Rouge, LA
USA
Highly Bio-available product
Not for medicinal use
Caution : Do not use if allergic to
Any content
No artificial color used
MFG Date :
BEST USE WITHIN 24 MONTHS
Manufactured in association with
Meda Biotech using
Hybrid Nanoenginring
30
Capsules
Editor's Notes
Cholesterol from the diet undergoes conversion to 7 dehydrocholesterol. As it circulates through the bloodstream and is taken up by cells such as skin cells, it is converted to cholecalciferol by UV exposure. Once it is converted and it enters the bloodstream, it is converted to 25-hydroxyvitamin D by the liver. It then goes to the kidneys and is finally converted to 1,25 dihydroxyvitamin D (active form). It can also be converted to the active form by many other organs in the body.
The vitamin D receptor is expressed in virtually all cells of the body and can influence chronic systemic, metabolic conditions.
Intake reference values for vitamin D and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by the Food and Nutrition Board (FNB) at the Institute of Medicine of The National Academies (formerly National Academy of Sciences).
Recommended Dietary Allowance (RDA): average daily level of intake sufficient to meet the nutrient requirements of nearly all (97%–98%) healthy people.
Adequate Intake (AI): established when evidence is insufficient to develop an RDA and is set at a level assumed to ensure nutritional adequacy.
Tolerable Upper Intake Level (UL): maximum daily intake unlikely to cause adverse health effects.
The FNB established an RDA for vitamin D representing a daily intake that is sufficient to maintain bone health and normal calcium metabolism in healthy people. RDAs for vitamin D are listed in both International Units (IUs) and micrograms (mcg); the biological activity of 40 IU is equal to 1 mcg (Table). Even though sunlight may be a major source of vitamin D for some, the vitamin D RDAs are set on the basis of minimal sun exposure.