The document discusses the challenges of clinical trial recruitment and retention, including delays, costs, and increased complexity. It introduces an online solution that uses digital campaigns, predictive tools, and a patient relationship management system to generate leads, screen candidates, enroll and engage patients, and optimize sites. The proposed approach aims to fill recruitment gaps cost-effectively with fast setup, total flexibility, patient centricity, and recent experience recruiting for trials in various therapeutic areas.
Clinical trials organization recruits 14,500 patients in 4 months
recruitment & retention introduction V2
1. On-line Recruitment & Retention 1Recruitment & Retention ǀ Gil Pal & Hagit Nof ǀ Aug 28th, 2016
On Line Patients Recruitment &
Retention Services
2. On-line Recruitment & Retention 2
Challenges
Loss of time
80% of clinical trials
fail to meet the
recruitment target on
time
Loss of money
Each day a drug
development
program is delayed,
costs $40K in
operational costs and
$600 to $8M in lost of
opportunities
Increased
complexity
Over the past decade,
the average eligibility
criteria for clinical
trials have increased
by 58%, while patient
enrollment rate
dropped by 21% and
retention rates fell by
30%
Dual competition
Competition is fierce
on each patient and
on site attention
3. On-line Recruitment & Retention 3
Solution
Reach out your patients
onlineSite optimization
Traditional
advertising
4. On-line Recruitment & Retention 4
How it works ?
Our services lead the patient
journey
Engag
ed
Learning the
study
specifications
and patients
target, to
provide
estimation
where best to
open sites on
the globe
Prediction
Using customer
retention
methods to
motivate the
patient to
complete the
study
Retention
Creating a
supportive
environment to
optimize the
recruitment
stage, by using
our PRM tool
Screening
Optimization
Evoke potential
patients
awareness to
the study and
invite them to
leave details
and consider
participation
Lead
Generation
Seeking
treatment
Trial
candidate
Enrolled Engaged
6. On-line Recruitment & Retention 7
Building an on-line campaign specifically
designed for your study to generate "leads" -
people who are considering to participate in
your study and interested to hear more
information.
The campaign targets audience per
geographical area and relevant criteria.
On-Line Lead Generation
8. On-line Recruitment & Retention 9
Few working days after IRB approval is
obtained, your campaign will be “on-air”.
At any country in every language you need.
Fast Set-Up
9. On-line Recruitment & Retention 10
Sites should recruit patients and we want you
to benefit from that. We supply leads only to
complete a recruitment gap.
No. of leads per site can be determined on a
monthly basis.
Filling the Gap
10. On-line Recruitment & Retention 11
Cloud-base customized PRM
tool is a significant aid for sites in
managing the recruitment,
screening & retention activities.
Constant insight on sites’
performances and lesson
learned from the success
stories.
Site Optimization
12. On-line Recruitment & Retention 13
• Success fee pricing model – you pay only
for leads you get.
• No Initial investment - stop the campaign
once patient target is achieved, without
compromising high fixed investment.
Cost Effectiveness
13. On-line Recruitment & Retention 14
Successful recruitment & retention process is
highly attached to the patient satisfactory
and commitment to the trial.
As a digital company, most communication
with the patients through their entire journey
in the clinical trial, will be automated, with no
extra work at site level.
Patient Centricity
14. On-line Recruitment & Retention 15
3 dimensions of flexibility:
• Choose which services you need per your
clinical trial stage.
• Choose which sites to involve, how many
leads to refer them and for how long.
• Change your choices when needed
Total Flexibility
Whether you are a sponsor, CRO or Hospital, patients’ recruitment is probably one of your biggest concerns.
Competition for trial subjects is intense and patient participation is a critical bottleneck in the clinical trials.
What do you find the most relevant challenge from your experience ?
What is your specific challenge in the study ?
In the traditional way, trial’s candidates are limited to the patient population of the physician/ site and once exhausted the site’s recruitment slows or halted.
nRollMed is specializing in extending the reach and the target population of the trial candidates by increasing the awareness to the trial to all potential patients within the sites geographical region no matter where the patients are treated, and have them actively approach the site and show interest in joining the trial.
nRollMed provides 2 layers in 1 service. In the first layer we provide leads of potential patients. We do that by developing a digital presence of the trial that explains the candidates about the trial, the team, its advantages and criteria and allow them to express interest to join.
The digital online advertising is active, i.e. constant evaluation of the website and new landing pages’ development in a format of A /B testing, that will ensure maximum effectiveness in the shortest time period.
In the second layer, and equally important, we provide the recruiting sites (hospital, clinic), effective tools to manage the recruitment process of the candidates and help keep high recruiting rate and reduce drop-outs at the recruitment stage. We also provide the sponsor periodic reports about the recruitment status.
time lost never comes back
In the second tier we do screening optimization. nRollmed keeps a direct contact with the sites. We provide them our in house and customized “patient relationship management tool”. The tool is a web based software, very easy to use and requires no efforts from the sites side . This effective tool is a game changer that helps to keep high recruiting rate and reduce drop-outs at the treatment stage. We also provide the sponsor periodic reports about the recruitment status.
Extend the reach for trial patients to the online world & optimize all sites performance
We suggest a different model of site identification, where patient recruitment is considered before sites and investigators are identified.
For years, the clinical trail industry invests much in identifying the sites with the correct qualifications and credentials, considering standard of care, key opinion leaders etc. and yet, 30% of sites will fail to recruit a single patient and 50%-70% will fail to meet their recruitment target. It is time to deploy new methods.
we will use live data about patients’ interest you can use as your main criterion in site selection.
The average cost of initiating a site is $20,000 - $30,000 and the estimated cost of maintaining sites is $1,500.
Our capabilities in identifying geographical locations where recruitment success is more probable, can dramatically influence your recruitment time and save a fortune
Whether you are a sponsor, CRO or Hospital, patients’ recruitment is probably one of your biggest concerns.
Competition for trial subjects is intense and patient participation is a critical bottleneck in the clinical trials.
Another
Another
“on-line Lead generation”
The process:
* Learning about the indication and study specifications
* Prepare material to IRB and obtain approval
* build a study “internet site” (landing page), where initial and clear details are presented and motivation is explained.
* unique digital search strategies are used to introduce the landing page to potential patients in social communities, search engines and other.
* Per geographical area, we provide sites with contact details of potential patients who agreed to be approached (leads).
we are not limited to each specific site patients. We create Study's online presence with exposure to geographical and criteria wise relevant audience.
2-3 working days after IRB approval is obtained, your campaign will be “on-air”. At any country in every language you need.
Filling the gap
We know how to attract people in the geographical areas relevant to the study, so you don't spend money on irrelevant potential candidates.
You can start working with us at the beginning of the recruitment stage, knowing you will pay only for those patients you want us to complete, so once sites ‘ ability to recruit is dropping, you are already set up with our solution
“Site optimization”
we want sites to work smarter. Not harder. Our cloud based system gives the site staff a supportive tool to easily manage and communicate with each patient. among other features, our system includes automatic appointment reminders, messages generator, synchronization among study staff members, current status of each patient, tasks initiation and prioritization. When sponsors are competing on study staff attention and fighting to improve performances, our system is a a necessary tool
We optimize the performances at the site level. We are using an in-house customized “patient relationship management" tool. The tool is a web based software, very easy to use and requires no efforts from the sites side. It is proven to be a significant aid to sites in managing the whole recruitment and screening activities, with automatic e-mails sent to patients, reminders and follow-ups on patients.
Once our PRM system is used, you can get performance reports on a weekly / monthly basis.
Cost effectiveness
Digital search is the most efficient way to recruit patients. 44% of people find out about studies through media. Only 14% gain the information from their physicians.
We don't use traditional methods of patients recruitment like existing databases, TV / Radio advertisements etc. We focus on the audience in the digital world who are currently showing interest (and not those who were interested in the past). This method is the most cost effective compare to any other and doesn't require a high initial investment. That means that you have the freedom to stop the campaign once patient target is achieved or for any other reason, without wasting money.
לאח עם filling the gap
או עם success fee
“Patient centricity”
When a patient is dropping out or not following study instructions, You lose twice.
Focusing on patient recruitment is not enough, and a more patient centric approach is needed to enable patients to be an integral part of the clinical trail until its successful completion.
we understand the success of the trial's recruitment & retention process is highly attached to the patient satisfactory and commitment to the trial. we manage & automate the engagement with him throughout all steps of it's trials journey to make sure of it.
Our experience shows an increase of up to 66% in recruitment if we are engaged at the beginning of the recruitment period and 30%-50% improvement if we step in to rescue a study failing to meet recruitment goals.
list of customers and medical fields experience
Psychiatry (brainsway, Optimise, Eulast), Oncology (Tiltanpharma), Gastroenterology (vibrant, Abott), Dermatology (mediwound, sol-gel) and more..