3. Mycobacterium Tuberculosis
Mycobacterium tuberculosis is a species of pathogenic
bacteria in the family Mycobacteriaceae and the
causative agent of Tuberculosis.
*Long, slender ,straight or curved about 3x0.3µm
Aerobic bacilli non spore forming .*
Acid fast bacilli*
*Mycolic acid ,waxes and lipidin cell wall
Slow growing doubling time(15-20hour)*
*non motile rod shape
4. The primary site of TB is in the lung
Infection can spread to other system
-Musculoskeletal
-Genitourinary
-Central nervous
5. Pathogenicity :
The tubercle bacilli resides within dendritic cells and
macrophages, and in an immunocompetent host, the
infection is walled off within a granuloma where it can
remain dormant for years. While many factors contribute
to its success, it is the thick, waxy cell wall of the bacillus
that prevents dehydration, affords protection against
varying levels of acidity and the detrimental affects of
free radicals. In many respects, it is the unique
architecture of the cell wall itself that makes
Mycobacterium tuberculosis (Mtb) infection relatively
difficult to treat with antibiotics
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15. Clinical Diagnosis
•.Radiological exams
•-chest X-ray or chest CT scan
•-present as pulmonary scarring cavity lesion,
infiltrates ,pleural effusion and atelectasis.
•.Bacterial exams
•-collection of sputum for the testing of blood
presence
•.Bacterial testing of biopsied from lungs
