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Mycobacterium tuberculosis and atypical mycobacteria

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Mycobacterium tuberculosis and Atypical Mycobacteria

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Mycobacterium tuberculosis and atypical mycobacteria

  1. 1. Mycobacterium tuberculosis and atypical Mycobacteria BDS 3-4-15
  2. 2. 1 Mycobacteria Features 2 Mycobacterium tuberculosis Pathogenesis 3 Mycobacterium tuberculosis Lab Diagnosis 4 Atypical Mycobacteria Classification 5 Atypical Mycobacteria Features
  3. 3. Mycobacteria Features Staining Properties
  4. 4. Mycobacterium tuberculosis Transmission and Epidemiology 1.7 Million Deaths 9 Million New Cases Mycobacterium bovis Intestinal Tuberculosis
  5. 5. Mycobacterium tuberculosis Growth & Medium
  6. 6. Mycobacterium tuberculosis Cell Wall & Cord Factor Trehalose Dimycolate
  7. 7. Mycobacterium tuberculosis Pathogenesis Lesions 1. Exudative Lesions 2. Granulomatous Lesions
  8. 8. Mycobacterium tuberculosis Pathogenesis Ghon Complex
  9. 9. Diagnosis of tuberculosis Latent Infection Active tuberculosis Smear examination Solid and liquid culture Identification Susceptibility testing methods TST IFN- techniques Molecular methods -Detection -Identification -Detection of resistance 9
  10. 10. Medically Important Mycobacteria
  11. 11. Atypical Mycobacteria Runyon’s Classification 1. Photochromogens 2. Schotochromogens 3. Nonchromogens 4. Rapid Growers
  12. 12. Group 1 Photochromogens Mycobacterium kansasi and M. marinum M. kansasii • Causes lung disease clinically resembling tuberculosis. • It is susceptible to the standard antituberculosis drugs. Mycobacterium marinum • Causes "swimming pool or "fish tank” granuloma . • These granulomatous, ulcerating lesions occur in the skin at the site of abrasions incurred at swimming pools and aquariums. • Treatment with a tetracyclines
  13. 13. Group 2 Scotochromogens Mycobacterium scrofulacium • Causes lymphadenitis
  14. 14. Group 3 Nonchromochromogens Mycobacterium avium and M. intracellulare Mycobacterium avium intracellulare complex • Cause tuberculosis like illness usually in immunocompromised patients • Highly resistant to antituberculosis drugs
  15. 15. Group 4 Rapid Growers Mycobacterium fortuitum and M. chelonei Mycobacterium fortuitum-chelonei complex • Rarely cause human disease. • Infections occur in immunocompomised patients and patients with catheters or prosthetic joints. • Resistant to antituberculous drugs.
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