3. INTRODUCTION
⢠More than 500 species of bacteria live in the oral cavity
⢠Yet bacterial infections â Aside from caries and Periodontal diseases â are rare to be
seen in the oral cavity due to:
⢠The barrier function of the oral epithelium
⢠The mechanical cleansing action
⢠The specific and non-specific antimicrobial substances in saliva
⢠The migration of phagocytic cells, predominantly neutrophils, into the gingival
crevice and oral cavity.
5. ACUTE NECROTIZING ULCERATIVE GINGIVITIS
⢠Synonyms
⢠Relatively uncommon in industrialized countries, young adults and more common in
males.
⢠Polymicrobial
⢠Clinical picture:
1. Punched out crater-like necrosis in the interdental papilla
2. Pseudo-membrane formation
3. Bleeding
4. Marked Halitosis and bad metallic taste
5. Advanced cases: Cervical Lymphadenopathy, fever and Malaise.
10. CLINICAL FEATURES OF ACTINOMYCOSIS
⢠Chronic indurated swelling in the submandibular area and neck
⢠Multiple foci of chronic suppuration.
⢠Multiple sinuses
⢠Sulfur Granules
⢠Osteomyelitis in Maxillary infections.
11.
12. DIAGNOSIS OF ACTINOMYCOSIS
⢠Radiography.
⢠Biopsy: granulomatous and inflammatory response with central abscess
formation. The microbial colonies are seen in the center
⢠Smear and Light Microscopy.
⢠Microbiological Culture.
13. TREATMENT OF ACTINOMYCOSIS
⢠IV Penicillin: 10 â 20 million units/ day for 4 â 6 weeks
⢠Oral Penicillin: 4 â 6 gms/ day for 6 â 8 weeks
⢠Drainage
⢠Surgical Excision of scar and sinus tract
14. SYPHILIS
⢠Treponema Pallidum
⢠Modes of transmission:
1. Sexual
2. Blood transfusion
3. Trans-placental inoculation
⢠Dark Ground Microscopy
Disease
Latency
Disease
Latency
Disease
15. PRIMARY SYPHILIS
⢠Chancre:
⢠Local to the infection site
⢠2 â 3 weeks after infection and disappears after another 2 weeks
⢠Painless indurated swelling, dark red in colour and with a glazed surface.
⢠Syphilitic Collar: Non-tender enlargement of the cervical lymph nodes.
16.
17. SECONDARY SYPHILIS
⢠May last for many years
⢠Generalized Rash
⢠Snail track ulcers: grey-white ulcers covered by a thick slough
18. TERTIARY SYPHILIS
⢠Syphilitic Leukoplakia
⢠Gumma: Chronic Granuloma, common in palatal tissues causing a tissue defect due
to breakdown
⢠Widespread systemic involvement
21. DIAGNOSIS OF SYPHILIS
⢠Serological tests.
⢠Venereal Disease Reference Laboratory (VDRL) test: + in 75% of Primary Syphilis and
100% of secondary Syphilis patients.
⢠The Treponema pallidum hemagglutination assay (TPHA)
⢠The fluorescent Treponema antibody absorbed test (FTA): + in 90% of primary
Syphilis patients
⢠The Treponema pallidum immobilization (TPI) test
22. TREATMENT OF SYPHILIS
⢠High Doses of Antibiotics Penicillin or Erythromycin or Tetracycline
⢠In primary syphilis the course of antibiotics is up to 1 month
⢠In late (or latent) syphilis this is for up to 12 weeks.
23. TUBERCULOSIS
⢠Mycobacterium Tuberculosis
⢠Endemic with 1/3 of the worldâs population being infected.
⢠Primarily a Respiratory disease with a Secondarily infected oral mucosa
⢠Clinical Features:
⢠The classical description of a tuberculous ulcer is of an irregular lesion with
undermined borders and covered by a grey slough
⢠The Tongue is most commonly affected but can affect other sites
⢠Tuberculosis Lymphadenopathy
24. DIAGNOSIS OF TUBERCULOSIS
⢠A tuberculous origin should be considered in the differential diagnosis of persistent
oral ulceration of unknown aetiology.
⢠Biopsy, with histopathological examination of ZiehlâNielsen staining, or by
immunofluorescent techniques.
⢠Chest X-Ray
⢠Treatment:
⢠The most common medications used to treat tuberculosis include: Isoniazid,
Rifampin, Ethambutol and Streptomycin.
25.
26. LEPROSY
⢠chronic, progressive bacterial infection caused by Mycobacterium leprae.
⢠It primarily affects the nerves of the extremities, the lining of the nose, and the
upper respiratory tract.
⢠Leprosy produces skin sores, nerve damage, and muscle weakness.
27.
28. GONORRHEA
⢠Neisseria Gonorrhoea by direct mucosal contact.
⢠Clinical Features:
⢠Purulent gingivitis
⢠Diffuse erythema and ulcers
⢠Tonsillitis
⢠TMJ affection
⢠Gonorrhoea in the orofacial area is likely to be underdiagnosed
⢠Treatment: varying from a single, high-dose intramuscular injection of procaine
penicillin to oral Amoxicillin to short courses of oral tetracycline or co-Trimoxazole.
31. SCARLET FEVER
⢠Etiology: group A streptococci
⢠Clinical features:
⢠Children
⢠Incubation period
⢠Pharyngitis, tonsillitis, fever
⢠Lymphadenopathy, malaise, headache
⢠Red skin rash
⢠Flushed face and circumoral pallor
⢠Strawberry tongue - Raspberry tongue
⢠Subsides in few days time
⢠Complications:
⢠Rheumatic fever
⢠Glomeriolo-nephritis
32. REFERENCES
⢠Tyldesleyâs Oral Medicine: Chapter 4: Infections of the gingivae and oral Mucosa
⢠Oral Pathology 4th edition: Chapter 11: Infections of the Oral Mucosa