Skin Ailments Psoriasis By Dr. Darbha Aneeta
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Skin Ailments Psoriasis
1. SKIN AILMENT
PSORIASIS
Dr. Darbha Aneeta
Yizhar Anae
Yizhar Academia Of Noesis And
Eupheus
draaradhya15@rediffmail.com / yizharanae@rediffmail.com
+91 8454075171 / +91 9730933851
2. An Auto – immune disorder
Results of body’s own immune / defence
system turning against it self
Affects the skin and joints.
External Manifestation of Internal Tumult
.
A scaly, chronic, recurring inflammatory
skin disorder.
Skin rapidly accumulates at these sites and
takes a silvery-white appearance.
Plaque a scaly, red , raised psoriatic patch
of skin .
Plaques frequently occur on the skin of the
elbows and knees, can affect any area
including the scalp and genitals.
Burning hurting stinging aggravating
symptoms.
3. Psoriasis is an inflammatory skin disorder
Skin cells replicate at an extremely rapid rate.
New skin cells are produced about eight times faster than normal--over
several days instead of a month--but the rate at which old cells slough
off is unchanged.
This causes cells to build up on the skin's surface, forming thick patches,
or plaques, of red sores (lesions) covered with flaky, silvery-white dead
skin cells (scales).
4. Spread
The disorder is a chronic recurring condition
Varies in severity from minor localized patch to
complete body coverage.
Fingernails and toenails frequently affected
(psoriatic nail dystrophy) - and can be seen as an
isolated finding.
Psoriasis can also cause inflammation of the
joints, which is known as psoriatic arthritis.
5. The cause of psoriasis is not known, but it is believed
to have a genetic component.
Several factors are thought to aggravate psoriasis.
These include stress, excessive alcohol consumption,
and smoking.
Individuals with psoriasis may suffer from depression
and loss of self-esteem.
As such, quality of life is an important factor in
evaluating the severity of the disease.
Certain medicines, including lithium salt and beta
blockers, have been reported to trigger or aggravate the
disease.
6. Two main hypotheses
1. Psoriasis as primarily a disorder of excessive growth and
reproduction of skin cells. The problem is simply seen as a
fault of the epidermis and its keratinocytes.
2. an immune-mediated disorder in which the excessive
reproduction of skin cells is secondary to factors produced by
the immune system.
T cells (which normally help protect the body against
infection) become active, migrate to the dermis and trigger the
release of cytokines (tumor necrosis factor-alpha TNFα, in
particular) which cause inflammation and the rapid production
of skin cells. It is not known what initiates the activation of
the T cells.
The immune-mediated model of psoriasis has been supported
by the observation that immunosuppressant medications can
clear psoriasis plaques.
7. Plaque psoriasis (psoriasis vulgaris) is the most
common form of psoriasis. It affects 80 to 90% of
people with psoriasis. Plaque psoriasis typically
appears as raised areas of inflamed skin covered with
silvery white scaly skin. These areas are called plaques.
Types of Psoriasis
8. Flexural psoriasis (inverse psoriasis)
appears as smooth inflamed patches of
skin. It occurs in skin folds, particularly
around the genitals (between the thigh
and groin), the armpits, under an
overweight stomach (pannus), and under
the breasts (inframammary fold). It is
aggravated by friction and sweat, and is
vulnerable to fungal infections.
Guttate psoriasis is characterized by
numerous small oval (teardrop-shaped)
spots. These numerous spots of psoriasis
appear over large areas of the body, such
as the trunk, limbs, and scalp. Guttate
psoriasis is associated with streptococcal
throat infection
9. Pustular psoriasis appears as raised bumps that are
filled with non-infectious pus (pustules). The skin
under and surrounding pustules is red and tender.
Pustular psoriasis can be localised, commonly to the
hands and feet , or generalised with widespread
patches occurring randomly on any part of the body.
10. Nail psoriasis produces a variety of changes in
the appearance of finger and toe nails. These
changes include discolouring under the nail
plate, pitting of the nails, lines going across the
nails, thickening of the skin under the nail, and
the loosening (onycholysis) and crumbling of the
nail.
11. Psoriatic arthritis involves
joint and connective tissue
inflammation.
Psoriatic arthritis can affect
any joint but is most
common in the joints of the
fingers and toes. This can
result in a sausage-shaped
swelling of the fingers and
toes known as dactylitis.
Psoriatic arthritis can also
affect the hips, knees and
spine (spondylitis). About
10-15% of people who have
psoriasis also have psoriatic
12. Erythrodermic psoriasis involves
Widespread inflammation
Exfoliation of the skin over most of
the body surface.
Accompanied by severe itching,
swelling and pain.
Result of an exacerbation of
unstable plaque psoriasis,
particularly following the abrupt
withdrawal of systemic treatment.
Can be fatal
Extreme inflammation and
exfoliation disrupt the body's ability
to regulate temperature and for the
skin to perform barrier functions.
13. Life’s Lessons
Anxiety
Fear
Old buried guck
I am being Threatened
Fear of being hurt
Deadening the sense of self
Refusing to accept responsibility for one’s own
feeling
Psycho – Sociological Problems
14. A diagnosis of psoriasis is usually based on
the appearance of the skin. There are no
special blood tests or diagnostic procedures
for psoriasis. Sometimes a skin biopsy, or
scraping, may be needed to rule out other
disorders and to confirm the diagnosis. Skin
from a biopsy will show clubbed pegs if
positive for psoriasis.
Another sign of psoriasis is that when the
plaques are scraped, one can see pinpoint
bleeding from the skin below (Auspitz's
sign).
15.
16. Other Triggering Factors
Stress and Emotional Distress
Climate and Temperature Changes
Skin Injury – Cuts, Bruises
Conventional Medicines -- Non – Steroidal anti –
inflammatory Drugs – Nimesulide/Diazepam/ Chloroquine/
Anti – hypertensives
Alcohol
Tobacco
Poor general health
Exposure to Ultra Violet Light
Infection
Puberty, Menopause and Pregnancy – changes hormonal level
17. Medications with the least potential for adverse
reactions are preferentially employed.
As a first step, medicated ointments or cream
application to the skin.
Exposur of the skin to ultraviolet (UV) radiation.
This type of treatment is called phototherapy.
The third step involves the use of medications which
are taken internally by pill or injection : systemic
treatment.
Over time, psoriasis can become resistant to a specific
therapy. Treatments may be periodically changed to
prevent resistance developing (tachyphylaxis) and to
reduce the chance of adverse reactions occurring:
treatment rotation.
20. Coal Tar
- Prefered for limited or scalp psoriasis
- Can be effective in widespread psoriasis
- Antimitotic, anti-pruritic
- No quick onset but longer remission
- Often combined with SA, UV light therapy
- 2 types: Crude coal tar and Liquor picis
carbonis
21. Dithranol
May restore normal epidermal proliferation and
keratinization
Useful in thick plaque psoriasis
Commonly used with SA
2 treatment approach: long contact and short
contact
Stains clothes, irritating to normal skin
22. Topical CS
Anti-inflammatory, immunosuppressive
Quick onset than coal tar and dithranol
Tachyphylaxis can occur
High potent agents used in severe cases, thick
plaques
AE local and systemic
Should not be stopped abruptly – rebound
psoriasis
23. Phototherapy
UVA, UVB, PUVA
UVB prefered
Administered by lamp, sunlight exposure alone
or in combo with another topical agent
PUVA (methoxsalen) given PO 2 hours before
UVA or lotion applied 30mins before exposure
AE: itch, edema
25. Systemic agents are generally
recommended for patients with
moderate-to-severe disease.
Moderate disease is defined as
greater than 5% body-surface
area involvement; severe disease
is defined by greater than 10%
26. Take in Sun – Light – Climatotherapy
Moisturize your skin
Reduce Weight
Relax
Up your fibre intake – Flaxseeds / Evening Primrose
Oil
Quit Smoking / Avoid Alcohol
Eat a Healthy diet – 4-5 helpings of fruits /
vegetables/ cooked dried beans / peas/ Nuts and
seeds
Reduce / Remove – red meat / animal fat/ sugar
Omega – 3 Supplement / Teaspoon of flaxseeds
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