Multiple sclerosis

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Materi Presentasi Biologi Molekuler Please contact me if you necessity to this presentation in gilangrizki.alfarizi@gmail.com

Health & Medicine

Autoimmune Disease
Multiple Sclerosis
Gilang Rizki Al Farizi
Prodi Magister
Fakultas Farmasi Universitas Ahmad Dahlan
Yogyakarta

Introduction
Definisi : Merupakan suatu peradangan diotak dan tulang belakang
yang menyerang substansia alba juga. Kerusakan
karena sel limfosit T pada antigen myelin (dimyelinisasi

Epidemiologi
Discussion Questions:
Why can’t certain blood types be mixed during a transfusion
Why doesn’t the body of a pregnant woman reject the fetus

Gen HLA class II
 Alel HLA class II menjadi lebih rinci menjadi
HLA-DRA, -DRB1, DRB -3, - DRB4, -DRB5,
-DPA 1, dan HLA-DQA1, -DQB1
 Pada perkembangan teknologi variasi HLA DRB1
terdapat 50 spesifisitas genom
 Fisiologis HLA kelas II sama halnya dengan
MHC kelas II, yaitu mempresentasikan antigen
exogen, misalnya protein bakteri (bacterial
peptide)

Types of Multiple sclerosis
1. Relapsing Limiting MS (RRMS
Ditandai dengan episode relaps atau eksaserbasi yang
diikuti dengan episode remisi (perbaikan
Relapsing Limiting MS (RRMS
2. Secondary progressif MS  tahap lanjut dari stage
RRMS
3. Primary Progressive MS
4. Primary relapsing MS

Medication
1. Deseases Modifying Agent Drugs
a. Interferon beta
b. Glatiramer asetat
c. Fongolimod
d. Natilzumab
e. Metoxantrone
2. Simptomatik

Resources:
• Campbell, Neil A. and Reece, Jane B. Biology. Benjamin Cummings., 6th edition. 2002.
• Marieb, Elaine. Essentials of Human Anatomy and Physiology. Pearson Education Inc., 2000.
• www.biology.arizona.edu/immunology/tutorials/immunology/main.html
• www.biologymad.com
• www.cdad.com/nih/immune2/index.html
• www.hhmi.org/biointeractive/disease/animations.html
• www.mayoclinic.com
• www.micro.msb.le.ac.uk/MBChB/2a.html
• www.ncbi.nlm.nih.gov/
• www.niaid.nih.gov/publications/autoimmune/autoimmune.html
• www.northarundel.com/aniplayer
• www.ntri.tamuk.edu/immunology/blood.html
• www.nci.nih.gov/sciencebehind/immune/immune00.html
• www.whfreeman.com/kuby/index.html

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