El 12 de mayo de 2017 celebramos en la Fundación Ramó Areces una jornada con IS Global y Unitaid sobre enfermedades transmitidas por vectores, como la malaria, entre otras.

2. New method for applying insecticides
Electrostatic coating technology:
• Developed by In2Care founder as window screening product against hay-fever
• Binds small pollen particles due to static charge
- No need for oil/water/solvents
- Netting can be washed (>30 times) & coating remains active >3 years
Patented Technology: WO2009048324A1

3. New method for applying insecticides
Electrostatic coating technology:
• Developed by In2Care founder as window screening product against hay-fever
• Binds small pollen particles due to static charge
Patented Technology: WO2009048324A1
Deltamethrin dust Fungus spores Pyriproxyfen particles
200 x 100 x 200 x
Can bind any bioactive particle <50 μm diameter

4. New method for applying insecticides
Electrostatic coating technology:
• Developed by In2Care founder as window screening product against hay-fever
• Binds small pollen particles due to static charge
Can bind any bioactive particle <50 μm diameter
and be used to infect/contaminate mosquitoes with a lethal dose
Patented Technology: WO2009048324A1
Andriessen et al. 2015
Proc Natl Acad Sci USA

5. Gauze used for malaria control in In2Care’s Eave Tubes
Phase 3 Trial in Ivory Coast

6. In2Care product innovation & scalability
• Mass scale Eave Tube insert production
• Customized drill support tools
• Automated insecticide powder applicator
• Recycling via steam cleaner

8. In2Care® Mosquito Trap
Innovation against Aedes vectors
Attracts, contaminates, spreads & kills

9. New combination of bioactives
1. Slow-killing fungus: Beauveria bassiana
2. Auto-disseminated larvicide: Pyriproxyfen
Applied on charged gauze floater: near water surface
Packaged in aluminum refills (10 x 18 cm)
Gauze + powder + odour tablets

10. • Impact on multiple life stages
• Mosquito-driven larval control
 target small/cryptic Aedes breeding sites
Mode of Action

11. Scientific validations
Publications:
• Snetselaar et al. Parasites & Vectors, 2014
• US-EPA field efficacy studies Manatee County, 2016
• Buckner et al. J Am. Mosq Control Assoc. submitted Feb 2017
Field trials (10 units per acre):
• Trinidad (IVCD MoH), Feb - May 2015
• Grand Cayman Island (MRCU), May - Nov 2015
• Manatee County Florida (MCMAD), 2016
• Puerto Rico CDC, Feb 2017 – July 2017
Adulticidal impact fungus
Control cohorts
5 In2Care traps
1 trap + 4 clean sites
Control Treatment
Larvicidal impact via disseminated PPF
>75% breeding
reduction in ovisites
near In2Care Trap
Courtesy: Buckner et al. 2017

12. Improved Product design
• More robust & stable
• Fewer components: easier to install
• No leakage risks
• More water (5L): less refilling
• Floater clips
• Stackable
• Easy fixation options
• Servicing reminder cap

13. Mass scale Production
Fully automated
Capacity = 30.000 traps / week

15. Welcome to our
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Community involvement
Providing a Notification Service
& Portal
• Targeted at do-it-yourself
segment
• Email reminders for servicing
• Direct professional support
for end-users
• Multi-lingual to start with
English and Spanish
• Next phase: WhatsApp / SMS
reminder functionality
• Privacy: no name & address
registration

16. In2Care® Trap distribution
• Registration/ sales approval in >25 countries
• US-EPA Section 18 Emergency exemption
Section 3 registration ongoing
Distributed via pest control distributors & GOs
- Government-based vector control
- NGOs / Institutes
- Mosquito Abatement Districts
- Professional Pest Control Operators

17. From innovation to vector control
- WHO VCAG dossier submitted
- Phase 3: Validate impact on disease
• Large-scale RCT in Malaysia with Bayer (start end 2017)
Integrated approach: Outdoor spraying & In2Care Traps
 measure impact on Dengue
- Integration in vector management
• Complement mosquito control efforts
• Cost-effective programs

18. Marius de Waard
Director In2Care Email: marius@in2care.org
www.in2care.org
Thank you