ME/CFS is a mysterious illness with suspected viral causes but no clear diagnostic or treatment path. It causes overwhelming fatigue, unrefreshing sleep, and chronic flu-like symptoms. A probable pathway involves an initial viral infection triggering an abnormal immune response and second infection, resulting in ongoing flu-like symptoms through mitochondrial dysfunction and impaired organ system function. The body adapts by redirecting energy production to basic functions, forcing rest to restore mitochondrial activity. A possible treatment plan focuses on pacing activities, improving nutrition, sleep, blood sugar and immunity, as well as detoxification.