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Alexander Ghanem & David Leistner
Antegrade Approach – How to start?
Minimalists‘ versus Maximalists‘ Approaches
17. September 2017
Our aim and its Paradigmata
Minimalists‘ view Maximalists‘ view
“The patient is treated in one attempt by the most
experienced operator fitted to his lesion complexity.“
Patient
Patient
ProcedureProcedure
Outcome
G. Werner
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
Minimalists‘ Appropriateness List
adopted from Prof. G. Werner, Darmstadt
• Selection of the patient with normal LV-EF
– Symptoms, but „asymptomatic“ patients may be
adapted to their limitations by a CTO...
– Ischemic territory should be > 10%
Relationship between mortality and extent
of myocardial ischaemia, depending on therapy
Montalescot / Sechtem et al., Eur Heart J 2013;34:2949–3003.
Hachamovitch et al., Circulation 2003;107:2900–2907.
OMT / Revascularisation
adopted from Prof. G. Werner, Darmstadt
• Selection of the patient with normal LVF
– Symptoms, but „asymptomatic“ patients may be
adapted to their limitations by a CTO...
– Ischemic territory should be > 10%
• In patients with akinesia and ischemic CMP
– Presence of viability tested by MRI
– A grey zone of scar tissue extension remains
Minimalists‘ Appropriateness List
Viability is a Continuum
Wilcox et al, JACC 2015
Baks T et al. JACC 2006;47:721-5
Improvement of LV-Function depends
on viability of revascularized myocardium
Adapted from Werner et al. JACC 2006;48:51-8
Collateral blood flow is never
sufficient...
Min vs. Max
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
(Retrograde) CTO PCI reduced markely
symptoms (angina and dyspnea)
Boden et al., NEJM 2007
PCI added to optimal medical
therapy did not improve outcome
Garcia S et al, JACC 2013;62(16):1421 –31
Outcome after incomplete versus
complete revascularisation in MVD
Farooq et al., Circulation. 2013; 128: 141-151
Prognosis is significantly related to
residual SYNTAX-Score
SYNTAX Revascularisation Index
Genereux et al., Am J Cardiology, 2015, DOI: 10.1016/j.amjcard.2015.03.056
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
1:0
Min vs. Max
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
CTO-lesion characteristics
Srivatsa et al. JACC 1997;29:955-63
Necrotic Core, Cholesterol,
inflammated Tissue
Fibrous-calcific Tissue
Micro Channels
Histological CTO Correlates
De Labriolle et al, Am J Cardiol 2008
Causes of failure of CTO-PCI
CTO Toyohashi Heart Center
Development of CTO-PCI procedure
Miracle
Conquest
Parallel wiring
IVUS guidance
Retrograde approach
1995 2000 2005 2010
Fielder XT
Pilot
Fielder FC
SION
MDCT
Corsair
wire, device
imaging modality
wiring technique
Complex PCI, NYC
Conquest
Parallel wiring
IVUS guidance
Retrograde approach
1995 2000 2005 2010
Fielder XT
Pilot
Fielder FC
SION
MDCT
Corsair
wire, device
imaging modality
wiring technique
ACS standard
Cross-It
Progress family
RG3
Ultimate
Gaia family
Fielder XT A/R
Wire evolution
Complex PCI, NYC
Conquest
Parallel wiring
IVUS guidance
Retrograde approach
1995 2000 2005 2010
Fielder XT
Pilot
Fielder FC
SION
MDCT
Corsair
wire, device
imaging modality
wiring technique
Wire evolution
Microcatheter
Finecross
Improve wire pushabilityConcentrate rotating force
for better wire control
Superior device passage for the next option
1. 2.
3.
Microcatheter
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
Min vs. Max
1:1
1:0
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
Guiding Backup
BEST OPTION FOR STRENGTHENING A GUIDE:
1. FIRST best maneuver- put the guide in power position or deep
seat the guide.
2. SECOND best maneuver – Add a second stiffer wire
3. THIRD best maneuver – change to a stronger guide
4. use the balloon anchoring technique
5. insert a smaller straight inside the current guide (mother &
child)
6. remove everything- change the short sheath to a longer one
Guiding Diameter
Ghione et al., Eurointervention 2013
Guiding Diameter
Habit #2: Begin with the End in Mind !
Habit #1: Begin with any End in Mind !
PCI - OPERATORS
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
1:1
1:0
1:2
Min vs. Max
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
Gasparini et al. JACC INTV, 7 (4), 2014.
Vessel Remodelling
Galassi et al., JACC 59 (8) 2012, 711-718.
N=100
Vessel Remodelling
+ 20 - 30%
Galassi et al., JACC 59 (8) 2012, 711-718.
Vessel Remodelling
6-month Follow-up
Gasparini et al. JACC INTV, 7 (4), 2014.
 Less is more !
Vessel Remodelling
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
1:1
1:0
1:2
1:3
Min vs. Max
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
Strategy
Patient
Selection
Standardized
Protocols
Min vs. Max
Strategy is often about what
you don‘t do!
Hybrid Approach
pC
dC
Pl
Hybrid Approach
Hybrid Approach
4
5
6 6´
 7
4´
4
B 2
Strategic Options
adopted from Prof. G. Werner, Darmstadt
The apparent length of the
occlusion is often shorter
than you think !
Bilateral Injection
Maximum Guide
Backup
Antegrade
Fielder XT/A/R or
Gaia 1  Gaia 2,
Confienza,
Progress
Penetration, then
step down
Antegrade
No stump
IVUS for guided
penetration?
Reentry-System
Crossboss /
Stingray
Distal good target
Parallel with stiff
wire
Retrograde
Feasible collateral
pathways
Symptoms
Objectified
Ischemia
Procedure:
Wires
Procedure:
Guiding
Outcomes:
Angiography
Strategy
Min vs. Max
CTO – PCI always should be
planned and performed
with a maximalist‘s mindset !

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