Fusion 1 day presentation
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The document discusses a new generation of contact lenses that release natural tear substitutes to maximize comfort and hydration during wear. The lenses incorporate a bipolymer of hyaluronic acid and tamarind seed polysaccharide, which have been shown to attract water, protect the corneal epithelium, and mimic natural ocular mucin. This fusion technology is intended to increase tear film stability and prolong hydration and lubrication for improved comfort during lens wear.
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Fusion 1 day presentation
- 1. The contact lens that thinksThe contact lens that thinks its an eye dropits an eye drop
- 2. Contact Lens Related Dry EyeContact Lens Related Dry Eye 55% of wearers experience end-of-day discomfort Most common cause of drop-out is due to discomfort 41% due to dryness symptoms
- 3. FUSION CONCEPT The new generation of contact lenses that release a natural tear substitute Safilens has dedicated years of research and innovation looking for ways to maximise contact lens comfort and optimise ocular hydration. Safilens believes the controlled release of bio- active substances during contact lens wear to be the key to maintaining the delicate relationship between the contact lens and the tear film
- 4. Hyaluronic AcidHyaluronic Acid Benefits in EyecareBenefits in Eyecare Biological polymer HA’s function in nature is to attract water extremely effective, even at very low concentrations Attracts 3000x its own weight in water Bio-adhesive properties Non Newtonian behaviour Protective effect on corneal epithelium
- 5. Tamarind Seed PolysaccharideTamarind Seed Polysaccharide (TSP)(TSP) Similar structure to ocular mucinSimilar structure to ocular mucin
- 6. HA + TSPHA + TSP The interaction between HA and TSP is cooperative forming a new bi-polymer Resulting performance > SUM of its 2 partsResulting performance > SUM of its 2 parts
- 7. Relative Performance of tearRelative Performance of tear substitutessubstitutes Natural Semi-synthetic Synthetic HA TSP HPMC CMC PVA PVP Hydration **** **** ** **** **** * Lubrication **** **** ** *** *** *** Muco- adhesive **** **** * **** * * Muco- mimetic **** **** * * * * Viscoelastic **** **** * *** * * Wound healing *** *** * ** * * Ref: Current Medical Research and Opinion (2006)
- 8. Non Newtonian Fluid at High Viscosity Non Newtonian Fluid at Low Viscosity Non-Newtonian BehaviourNon-Newtonian Behaviour
- 9. How it works…How it works… Polymer chains become more disorganised with heating increasing its fluidity Sheer force from blinking aids flow into tears Non-Newtonian behaviour mimics the natural tears More fluid during blink – more viscous between blinks
- 10. Fusion Technology Increased tear film stability for improved comfort Prolonged muco-mimetic activity Maintains lens hydration longer Constant hydration and lubrication for excellent VA Minimal friction between lens and lid
- 11. Ultra-thin lens design Handles well Lens can be pulled quite robustly without breaking Excellent DK/t: 40 (-3.00 at 35ºC) More or less same as other hydrogel daily disposables Lens designLens design
- 13. -0.50 to -6.00 (0.25 steps) -6.50 to -12.00 (0.50 steps) Filcon IV Incorporating a bipolymer of HA-TSP
- 14. At the end of the day, whichAt the end of the day, which would you choose?would you choose?
Editor's Notes
- OPEN EYE Low shear force/high viscosity Protects against tear break-up Resists loss from drainage or evaporation CLOSED EYE High shear force/low viscosity Protects against epithelial damage Spreads evenly for good vision Viscosity of water is the same regardless of the force applied to it. In the eye we want the tears to be more stable between blinks and ‘runnier’ during the blink. Non newtonian molecules do this. HA/TSP molecules in gel form are all tangled up – when a shear force (such as blinking) is applied they untangle and align making them thinner and more water like.