Exosomes have been found in ascites fluid. And the ascites-derived exosomes from patients with cancer can mirror the pathological state of tumor. https://www.creative-biolabs.com/exosome/exosome-isolation.htm

1. Exosome-based immunotherapy has been integrated into conventional treatments in a way
which maximizes specific T cell activation and minimizes prevalent immunosuppressive
influences of the tumor. Based on abundant experience and professional technical team,
Creative Biolabs is committed to providing exosomes related services for global customers.
Now, we are happy to introduce ascetic cell-derived exosomes (AEX)-based vaccines
development to global clients.
Introduction of Ascetic Cell-derived Exosomes (AEX)
Ascites is initiated and maintained by physical and biological factors resulting from underlying
disease and forms an ecosystem that contributes to disease progression. Cellular components
of ascites communicate with each other through soluble factors, including cytokines, proteins,
metabolites, and through the secretion and exchange of exosomes. Ascitic cell-derived
exosomes (AEX) are exosomes isolated from an ascetic cell of patients with malignant cancer.
They contain molecular signatures of donor cells and can circulate throughout the body,
potentially transferring information between cells to alter gene expression in recipient cells. A
multitude of pathways can be activated because of cellular interactions with exosomal
molecules, including mRNAs, miRNAs, and proteins (e.g., heat shock proteins [HSPs] and
adhesion molecules). Furthermore, studies have shown that exosomes contain diverse
immunomodulatory markers and carcinoembryonic antigen (CEA).
Ascetic Cell-derived Exosomes (AEX)-based
Vaccines
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2. Fig.1 A summary of the roles of exosomes in ovarian cancer. (Li, 2017)
Application of Ascetic Cell-derived Exosomes (AEX)-based Vaccines
Depending on the cellular origin, exosomes contain various cellular proteins that may be
different from proteins that are normally located in the plasma membrane including MHC
molecules, tetraspanins, adhesion molecules, and metalloproteinases. Recent evidence
suggests that the application of AEX could emerge as novel nanoscale immunotherapy
treatments for cancer, by priming the body’s immune system to recognize and kill cancer
cells. What’s more, a phase I colorectal cancer clinical trial of autologous AEX has been
explored whereby 40 advanced stage patients were vaccinated subcutaneously once a week
for a total of four weeks with AEX alone or in combination with recombinant GM-CSF. It
suggests that AEX vaccination is feasible, safe and well tolerated.
In the past years, significant clinical advances have been made in the treatment of cancer
through the immune system. As a new vaccine method for cancer immunotherapy, AEX shows
great potential for the treatment of numerous tumors. The successful development of AEX-
based vaccines will further expand the weaponry to battle cancer. In addition to the AEX-
based vaccine, tumor cell-derived exosomes (TEX)-based cancer vaccines and dendritic cell-
derived exosomes (DEX)-based vaccines have also been developed for immunotherapy. For
more information, please feel free to contact us.
Reference:
1. Li, X.; Wang, X. The emerging roles and therapeutic potential of exosomes in epithelial
ovarian cancer. Molecular cancer. 2017, 16 (1):92.
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3. Dendritic Cell-derived Exosomes (DEX)-based Vaccines
Tumor Cell-derived Exosomes (TEX)-based Vaccines
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