Depending on the cell of tissue of origin, exosomes act as many different roles and functions including eradication of obsolete molecules, intercellular communication, antigen presentation, programmed cell death, dissemination of oncogenes from tumor cells, and spread of pathogens, such as prions and viruses from one cell to another, and transfer of tumorigenic proteins, mRNA and miRNA. For example, exosomes from certain cells of the immune system, such as dendritic cells and B cells, containing immunologically active substance can transfer molecules from one cell to another via membrane vesicle trafficking, thereby mediating adaptive immune responses to pathogens and tumors. https://www.creative-biolabs.com/exosome/services.htm

1. With years of hard working in exosome therapy field, Creative Biolabs has successfully
operated a platform that provides the most comprehensive exosome related services. We aim
to help global customers to facilitate the translational applications of exosome in disease
therapy.
Background of Exosome Therapy
Since exosome carriers possess many advantages in both cell-based drug delivery and
nanotechnology, interest in using exosomes for therapeutic approaches has exploded in
recent years. Due to their small size, exosomes are able to cross barriers that cells cannot.
Because of their characteristics of endogenous systems, exosomes show low immunogenicity.
Moreover, compared to other non-viral delivery systems, exosome-based delivery system
possesses higher loading efficiency and sustained drug release. Thus, exosomes have been
recently used for the treatment of many different diseases, including cancer, infectious
diseases and heart disease.
Exosomes Application in Cancer
With their capability to transferring bioactive molecules between cancer and various cells,
exosomes have been reported to participate in cancer progression and metastasis.
Selectively, exosomes derived from specific sites can be promising candidates for anticancer
vaccines since they can present antigens against that specific type of cancer. In addition,
exosomes can be engineered to carry a range of contents such as a gene or drug via using a
virus to “load” the exosomes. Furthermore, the surface of exosome has been modified to
support tumor-targeted delivery of contents. The exosome-based drug delivery system is
critical in the treatment of metastatic cancers.
Diseases
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2. Fig. 1 Loading exosomes with therapeutic cargo can be achieved in two ways. (Munson, 2015)
Exosomes Application in Infectious Diseases
Exosomes have been reported to function a role in the pathological process of infectious
diseases. Exosomes derived from pathogens influence the host immune system. While
exosomes derived from host cells may defend against infections. It has been reported to
block the exosomes secretion from infectious pathogens of viruses may be a potential
strategy to curb virus infections or inflammatory reactions in infection control. Besides,
modification of the contents of exosomes may also be a potential strategy for anti-infection
therapy.
Exosomes Application in Central Nervous System (CNS) Disorders
The blood-brain barrier (BBB) is a highly selective semipermeable border that separates the
circulating blood from the brain and extracellular fluid in the CNS. Many compounds cannot
cross the BBB, which restricts their therapeutic potential . Exosome-based delivery system
can carry effective drugs across BBB and transport into the brain, which provides a novel
therapeutic strategy for CNS disorders.
Exosomes Application in Cardiac Diseases
Exosomes have been reported to act as an essential role in cardiac cell function and used for
an effective carrier for drugs delivery into target cardiac cells. And stem cell-derived
exosomes have also been indicated to play a cardioprotective roleby activating regenerative
signals and participating in cardiac repair. These suggest that exosome-based therapy can be
applied for cardiac diseases treatment.
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3. Fig. 2 Therapeutical potential of extracellular vesicles in the context of cardiovascular disorders. (Fleury, 2014)
With the help of our advanced technologies and skillful scientists, Creative Biolabs can
provide the best exosome-related services, including exosome sampling, profiling,
manufacture and exosome engineering. Please contact us to discuss your project and create a
custom quote.
References:
1. Munson, P.; Shukla, A. Exosomes: potential in cancer diagnosis and therapy. Medicines, 2015,
2(4):310-327.
2. Fleury, A.; et al. Extracellular vesicles as therapeutic tools in cardiovascular diseases. Front
Immunol, 2014, 5(3):370.
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Approaches Utilized for Drug Loading into Exosomes
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