Anti obesity drugs

1. BWI > 35, resp. BW gra-
ter than 30% above ideal,
is associated with the
development of arterial
hypertension, DM, gout,
osteoarthrosis, hiatus
hernia, hyperlipidemia,
sex problems, etc ...
47% > ....47% > ....
Anti-obesity DrugsAnti-obesity Drugs
(Abstract)(Abstract)
Anti-obesity DrugsAnti-obesity Drugs
(Abstract)(Abstract)

3. B.M. (kg)
height
(m)2
Norm:Norm:
18.518.5––24.924.9
BMI (BWI)BMI (BWI)

4. LeptinLeptin is a peptide hormone,
synthesized and secreted
from adipose tissue.
It acts on hypothalamus:
suppresses appetite, increases body
temperature and increases energy
costs. It is created recombinant leptin!

5. Sponsored
Medical Lecture Notes – All Subjects
USMLE Exam (America) – Practice

6. GhrelinGhrelin is a peptide hormone. It is produced
mainly by the fundus of the stomach and
epsilon cells of the pancreas. It stimulates
hunger. Ghrelin levels increase before meals
and decrease after meals. It is considered the
counterpart of the hormone leptin, produced
by adipose tissue, which induces saturation
when present at higher levels.
Ghrelin is a potent stimulator of GHGhrelin is a potent stimulator of GH
releaserelease tootoo..

8. OrlistatOrlistat (INN)
– AlliAlli®®
: caps. 60 mg
– XenicalXenical®®
:
caps. 120 mg
It inhibits
lipase in the GIT.
ADRs: Diarrhoea.
Orlistat is reducedOrlistat is reduced
BM with 10% afterBM with 10% after
6 – 8 months.6 – 8 months.

10. Sibutramine
Its active metabolites inhibit
the reuptake of 5-HT, NA and
DA in CNS. Sibutramine can
cause hypertension, tachycardia,
insomnia, cardiovascular incidents.
It is out of date and not use.
Rimonabant
It is a selective inhibitor of the canabinoid CB1-receptors.
ADRs: Depression. Rimonabant is out of date and not use.
MetforminMetformin::
tablets 500 and 1000 mgtablets 500 and 1000 mg

11. THINK GREEN

14. www.medpharm-sofia.eu
> 500 files & > 250 links
www.medpharm-sofia.eu
> 500 files & > 250 links