#Bronchial asthma #Drugs for bronchial asthma #Mechanism of action of β2 receptor agonists in Bronchial Asthma #Mechanism of action of Methylxanthines in Bronchial Asthma #Mechanism of action of Anticholinergics in Bronchial Asthma #Mechanism of action of Leukotriene antagonists in Bronchial Asthma #Mechanism of action of Mast cell stabilizers in Bronchial Asthma #Mechanism of action of Corticosteroides in Bronchial Asthma

1. BRONCHIAL ASTHMA AND
DRUGS FOR BRONCHIAL
ASTHMA

2. INTRODUCTION
Bronchial asthma is
hyperresponseiveness of
tracheobronchial smooth muscle to a
variety of stimuli, resulting in increased
secretion, mucosal edema and mucosal
plugging, along with narrowing of air
tubes

4. DRUGS FOR BRONCHIAL ASTHMA
1) Bronchodialators
• β2 receptor agonists e.g. Salbutamol, Terbutaline, Ephedrine
• Methylxanthines e.g. Theophylline, Aminophylline, Doxophylline
• Anticholinergics e.g. Ipratropium bromide

5. 2) Leukotriene antagonists
e.g. Montelukast, Zafirlukast
3) Mast cell stabilizers
e.g. Sodium cromoglycate
4) Corticosteroides
Systemic e.g. Hydrocortisone, Prednisolone
Inhalation e.g. Beclomethasone dipropionate, Budesonide

6. Mechanism of action of β2 receptor agonists
and Methylxanthines

7. Mechanism of action of Anticholinergics

8. Mechanism of action of Mast cell stabilizers and Leukotriene antagonists

9. Mechanism of action of Corticosteroides
• Glucocorticoids not do bronchodialation,
• Works by reducing bronchial hyperactivity
• Reduces mucosal edema
• Supresses antigen antibody reaction
• Thus they work by suppressing inflammatory response

10. THANK YOU
PRESENTED BY
DR. V. K. PATHAK