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0210-5691/ © 2022 Elsevier España, S.L.U. y SEMICYUC. Todos los derechos reservados.
medicina intensiva
www.medintensiva.org
Medicina Intensiva 46S1 (2022):1-13
https://doi.org/ 10.1016/j.medin.2022.03.017
Volumen 34, Número 5. Junio-Julio 2010
Sociedad Española
de Medicina Intensiva, Crítica
y Unidades Coronarias
Federación Panamericana
e Ibérica de Sociedades
de Medicina Crítica
y Terapia Intensiva
www.elsevier.es/medintensiva
www.semicyuc.org
www.fepimcti.org
Incluida en:
Index Medicus/MEDLINE
EMBASE/Excerpta Medica
SCOPUS
ISSN:
0210-5691
Editorial
Diagnóstico precoz del fracaso renal agudo
M. Rodríguez López y A. Roglan Piqueras
291
Originales
Concordancia en pacientes críticos entre las
ecuaciones diseñadas para la estimación
del filtrado glomerular y el aclaramiento de
creatinina en orina de 24h
G. Seller-Pérez, M.E. Herrera-Gutiérrez,
E. Banderas-Bravo, R. Olalla-Sánchez,
R. Lozano-Sáez y G. Quesada-García
294
Sincronía auriculo-ventricular en pacientes
portadores de marcapasos con estimulación
VDD. Estudio descriptivo de un periodo de
14 años
A. Canabal Berlanga, M. Sánchez Casado,
J.M. Díaz Borrego, A. Raigal Caño y
P. Sánchez Rodríguez
303
Síndrome de Distrés Respiratorio Agudo,
durante la pandemia de Influenza A H1N1
2009 en Ecuador
G. Paredes y C. Cevallos
310
Puesta al día: El enfermo crítico con
infección grave
Neumonía asociada a la ventilación
mecánica
E. Diaz, L. Lorente, J. Valles y J. Rello
318
Debates en Medicina Intensiva:
Empleo de Descontaminación
Digestiva Selectiva
Pro descontaminación selectiva
M. Sánchez García
325
Descontaminación: un tratamiento sin
indicaciones
E. Palencia Herrejón y P. Rico Cepeda
334
Revisión
Hemofiltración de alto volumen en shock
séptico
C.M. Romero, P. Downey y G. Hernández
345
Nota clínica
Hiperinfección por Strongyloides stercoralis
J. Llagunes, E. Mateo, J.J. Peña, P. Carmona y
J. de Andrés
353
Cartas al Director
Administración accidental de dosis tóxicas
de adrenalina intravenosa a un lactante de
5 meses
M.S. Holanda Peña, J.L. Teja Barbero,
J. Velasco Montes y M. López Sánchez
357
Diagnóstico tardío de un caso de porfiria
aguda intermitente en una unidad de
cuidados intensivos
A.J. Betbesé, L. Zapata, C. Martínez-Brú y
C. Herrero
358
Muerte encefálica aparente tras sobredosis
de baclofén
R. Salas De Zayas, F. San José Pacheco,
C. Dolera Moreno y L. Zoila Peiró
359
Imágenes en Medicina Intensiva
Embolia aérea pulmonar como complicación
de punción venosa central
J. Bayón, M. Martín e I. Lozano
360
Actividad acreditada
en base a la encomienda de gestión concedida por los Ministerios
de Educación, Cultura y Deporte y de Sanidad y Consumo
ciales de Médicos con
2,1 créditos equivalentes a 10 horas lectivas.
www.formacion.elsevier.es/medicinaintensiva
COMISIÓN
DE FORMACIÓN
CONTINUADA DEL SNS
PALABRAS CLAVE
Sepsis;
Shock séptico;
Respuesta
LQÁDPDWRULD
Citocina;
Endotelio;
Endotoxina;
0LFURFLUFXODFLyQ
Resumen La sepsis y el shockVpSWLFRVRQHOUHVXOWDGRGHXQDUHVSXHVWDLQDGHFXDGDGHOKXpVSHG
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RUJiQLFD+DJUDQFDQWLGDGGHHYLGHQFLDVREUHHOSDSHOGHODHQGRWR[LQDHQODSDWRJpQHVLVGHOD
VHSVLVHOSDSHOIXQGDPHQWDOTXHWLHQHHQHOLQLFLRGHODUHVSXHVWDLQÁDPDWRULDHQODVHSVLVFDX-
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‹(OVHYLHU(VSDxD6/86(0,87RGRVORVGHUHFKRVUHVHUYDGRV
Pathophysiology of septic shock
Abstract 6HSVLVDQGVHSWLFVKRFNUHVXOWIURPDQLQDGHTXDWHKRVWUHVSRQVHWRDQLQIHFWLRQ
ZKLFKFDXVHVRUJDQGVIXQFWLRQ7KHSURJUHVVLRQRIWKLVFRQGLWLRQLVPDQLIHVWHGEWKHRFFX-
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$XWRUSDUDFRUUHVSRQGHQFLD
Correo electrónico:UIHUUHU#YKHEURQQHW 5)HUUHU 
5(68,7$,Ð1'(/3$,(17(216(36,6SHOCK6e37,2
Fisiopatología del shock séptico
Luis Chiscano-Camóna,b,c
, Erika Plata-Menchacaa,b
, Juan Carlos Ruiz-Rodrígueza,b,c
y Ricard Ferrera,b,c,
*
a
Servicio de Medicina Intensiva, Hospital Universitario Vall d’Hebron, Barcelona, España
b
Grupo de Investigación Sepsis Organ Dysfunction and Resuscitation (SODIR), Vall d’Hebron Institut de Recerca (VHIR),
Hospital Universitari Vall d’Hebron, Barcelona, España
c
Departament de Medicina. Universitat Autònoma de Barcelona. Barcelona. España
KEYWORDS
Sepsis;
6HSWLFVKRFN
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Endotoxin;
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FDORXWFRPHV
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Introducción
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Medicina Intensiva 46S1 (2022):1-13 3
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VHHQFXHQWUDHQWRGRV
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nuevos YDVRVVDQJXtQHRV (DQJLRJpQHVLV HODXPHQWRGH
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FLQLQRJHQDVD
/DEUDGLFLQLQDFDXVDYDVRGLODWDFLyQSRUPHGLRGHOD
VHFUHFLyQGHSURVWDFLFOLQDVy[LGRQtWULFRHOIDFWRU
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es un potente YDVRGLODWDGRU dependiente del endotelioTXH
SURYRFDODFRQWUDFFLyQGHOP~VFXOROLVRQRYDVFXODUDXPHQWD
la SHUPHDELOLGDGYDVFXODUWDPELpQHVWiUHODFLRQDGRFRQ
HOPHFDQLVPRGHOGRORU(QFLHUWRVDVSHFWRVDFW~DGHPDQHUD
VLPLODUDODKLVWDPLQDDOLJXDOTXHHVWDVHVHFUHWD
en las vénulas y no en las DUWHULRODV
Medicina Intensiva 46S1 (2022):1-13 5
Tabla 1 3ULQFLSDOHVPHGLDGRUHVLQÁDPDWRULRVHQODVHSVLV(cont.)
Ð[LGRQtWULFR 9DVRGLODWDGRU
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DODDFWLYDFLyQFRQHOORODDJUHJDFLyQROLEHUDFLyQ
SODTXHWDULD8QDSURGXFFLyQH[FHVLYDGH12FDXVDOD
UHODMDFLyQGHODVDUWHULDVXQDSUHVLyQVDQJXtQHD
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de tipos de
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de los leucocitosDQWLDJUHJDQWHSODTXHWDULRHVWtPXORGH
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VpSWLFRODGLVIXQFLyQPXOWLRUJiQLFD(QHOVLVWHPD
FDUGLRYDVFXODULQFUHPHQWDODIUHFXHQFLDFDUGLDFDHOtQGLFH
FDUGLDFRGLVPLQXHODVUHVLVWHQFLDVYDVFXODUHVVLVWpPLFDV
KDVWDODKLSRWHQVLyQ$QLYHOPLFURYDVFXODUODHQGRWR[LQD
DFWLYDODFRDJXODFLyQORVVLVWHPDVGHFRQWDFWR
GHOFRPSOHPHQWRÀEULQROtWLFR$FW~DHQHOHQGRWHOLR
LQKLELHQGRODDFFLyQGHDQWLFRDJXODQWHVHQGyJHQRV
SURGXFLHQGRUDGLFDOHVOLEUHVHLQFUHPHQWDQGRODSURGXFFLyQ
GH12$GHPiVDFWLYDORVPDFUyIDJRVLQGXFLHQGRODVtQWHVLV
GHFLWRFLQDVORVQHXWUyÀORVFDXVDQGROHVLyQHQGRWHOLDO
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SURWHROtWLFDV
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TXHLQPRYLOL]DQDOSDWyJHQRHVWLPXODQRWUDVVXV-
WDQFLDVLQÁDPDWRULDV(VWRVSURFHVRVFRQOOHYDQODDFWLYDFLyQ
GHODFDVFDGDGHODFRDJXODFLyQ18
(ÀJXUD 'HKHFKRORV
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SUHVHQWDQXQDXPHQWRGHODVUHGHVGHQHXWUyÀORWLVXODU19

(OVLVWHPDGHOFRPSOHPHQWRWDPELpQHVWiLPSOLFDGRHQOD
ÀVLRSDWRORJtDGHODVHSVLV7DQWRODIUDFFLyQD D FRPR
VXUHFHSWRU D5 VRQDFWRUHVUHOHYDQWHV7UDVODXQLyQFRQ
ORVQHXWUyÀORVHVWHHOHPHQWRGHOVLVWHPDGHFRPSOHPHQWR
SHQHWUDHQODFpOXODGRQGH3$03'$03LQGXFHQODUHG
QHXWURItOLFDTXHJHQHUDGDxRR[LGDWLYRFRDJXORSDWtDFD-
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tico20
8QDDFWLYDFLyQH[FHVLYDGHDFDXVDDSRSWRVLVGHORV
OLQIRFLWRVGLVIXQFLyQGHORVQHXWUyÀORV21

([LVWHXQDKHWHURJHQHLGDGRYDULDELOLGDGLQWHULQGLYLGXDO
FRQVLGHUDEOHHQODUHVSXHVWDLQÁDPDWRULDGHVFULWDTXHVH
PRGXODSRUYDULRVIDFWRUHVFRPRODKLSRJDPPDJOREXOLQH-
PLD22
ORTXHPRWLYDGLÀFXOWDGHVHQHOGLDJQyVWLFRHOWUDWD-
PLHQWR23
%HUPHMR0DUWLQHWDOKDQGHVFULWRKDVWD
LQPXQRIHQRWLSRVGLVWLQWRVDVRFLDGRVFRQODLQPXQRVXSUH-
VLyQHOGHVHTXLOLEULRLQPXQROyJLFRHQODVHSVLV/RVIHQRWL-
SRVTXHGHVFULEHQVRQODVDOWHUDFLRQHVFXDQWLWDWLYDV
FXDOLWDWLYDVHQODV3$ORVOLQIRFLWRV%7ODVFpOXODV1. y
ORVQHXWUyÀORV7DPELpQGHVFULEHQDOWHUDFLRQHVHQODSUR-
SRUFLyQGHODVFpOXODV7UHJXODGRUDVHOLQFUHPHQWRHQOD
H[SUHVLyQGHODSURWHtQDprogrammed cell death protein-1
3' KLSRJDPPDJOREXOLQHPLDKLSHUFLWRFLQHPLDGLVIXQ-
FLyQGHOVLVWHPDGHFRPSOHPHQWRHOLPSRUWDQWHSDSHOGH
ODVUHGHVH[WUDFHOXODUHVGHQHXWUyÀORHQHOGHVDUUROORGHOD
LQIHFFLyQ24
/RVDXWRUHVSURSRQHQTXHVXHVWXGLRFRQGX]FDD
XQWUDWDPLHQWRSHUVRQDOL]DGR(VWH~OWLPRDVSHFWRQRVH
WUDWDHQHVWDUHYLVLyQ
Endotelio y coagulopatía en la sepsis
/DDFWLYDFLyQGHODFDVFDGDGHODFRDJXODFLyQHQHOSDFLHQWH
VpSWLFRVHUHFRQRFHFRPRSDUWHGHXQDUHVSXHVWDLQPXQLWD-
ULDDGDSWDWLYDGHOKXpVSHGDODLQIHFFLyQ25
6LQHPEDUJROD
FRDJXODFLyQLQWUDYDVFXODUGLVHPLQDGD ,' TXHSXHGHDSD-
UHFHUHQSDFLHQWHVFRQVHSVLVHVHOUHVXOWDGRGHXQDDFWLYD-
FLyQGHVPHGLGDGHOHWpUHDGHODFRDJXODFLyQ26
6HWUDWDXQ
VtQGURPHDGTXLULGRFDUDFWHUL]DGRSRUDFWLYDFLyQGHORVIDF-
WRUHVGHODFRDJXODFLyQRULJLQDGRVDUDt]GHXQGDxRHQHO
/KLVFDQR(3ODWD0HQFKDFD-5XL]5RGUtJXH]HWDO
OHFKRPLFURYDVFXODUTXHSXHGHOOHJDUDFDXVDUGLVIXQFLyQ
RUJiQLFDGHSHQGLHQGRGHVXPDJQLWXG
$OFDQ]DXQDJUDQ
YDULHGDGGHHQWLGDGHVFOtQLFDVFRQIHQyPHQRVKHPRUUiJL-
cos en etapas iniciales28
DOWHUDFLRQHVHQODVSUXHEDVGHFRD-
JXODFLyQRLVTXHPLDGLVWDOGHODVH[WUHPLGDGHVSRU
IHQyPHQRVWURPEyWLFRV29
6RQORVIDFWRUHVFODYHTXHFRQ-
WULEXHQHQOD,'ODDFWLYDFLyQGHODFDVFDGDGHODFRDJX-
ODFLyQODDJUHJDFLyQSODTXHWDULDHOGDxRHQGRWHOLDO
Activación de la cascada de coagulación
EORTXHRÀEULQROtWLFR
/DVHSVLVVHFDUDFWHUL]DSRUXQHVWDGRSURWURPEyWLFRMXQWR
FRQEORTXHRÀEULQROtWLFRDPERVVRQORVPHFDQLVPRVIXQ-
GDPHQWDOHVGHOD,'+DXQDVHULHGHPHGLDGRUHVLQÁDPD-
WRULRVTXHSURPXHYHQODDFWLYDFLyQGHODWURPELQDHQODYtD
FRP~QGHODFRDJXODFLyQFRPRSDUWHGHODUHVSXHVWDGHO
KXpVSHGDODLQIHFFLyQ30
(OIDFWRUWLVXODU )7 SRUVXSDUWH
FRPRDFWLYDGRUGHODYtDH[WUtQVHFDVHH[SUHVDHQPDFUyID-
JRVPRQRFLWRVFpOXODVHQGRWHOLDOHV31
/DDFFLyQFRQMXJDGD
GH3$03'$03HVHOIDFWRUGHWHUPLQDQWHSDUDHOLQLFLRGHO
SURFHVR$GHPiVLQWHUYLHQHQRWURVPHGLDGRUHVKXPRUDOHV
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FRPSOHPHQWRTXHWDPELpQVRQIDFLOLWDGRUHVGHOSURFHVR32

,QFOXVRODVUHGHVH[WUDFHOXODUHVGHQHXWUyILORVDFWLYDGRV
WDPELpQHVWiQLPSOLFDGDV33

1RVHSURGXFHH[FOXVLYDPHQWHXQDDFWLYDFLyQGHODFDVFD-
GDGHODFRDJXODFLyQVLQRGHORVHOHPHQWRVTXHODUHJXODQ
FRPRHOVLVWHPDILEULQROtWLFRTXHVHDOWHUDQHQWUDQHQ
GLVIXQFLyQ6HKDOODQYDORUHVHOHYDGRVGHOLQKLELGRUWLVXODU
GHSODVPLQyJHQRTXHSURGXFHQXQYLUDMHDXQHVWDGRGH
WURPERÀOLDHQOD,'34
'HKHFKRVXFRQFHQWUDFLyQSODVPi-
WLFDVHKDUHODFLRQDGRFRQGLVIXQFLyQRUJiQLFDPRUWDOLGDG
en la sepsis35
7DPELpQKDXQDUHJXODFLyQDODEDMDGHORV
LQKLELGRUHVGHODWURPELQD36
HOSODVPLQyJHQR
HLQFUHPHQ-
WRGHOLQKLELGRUGHODFWLYDGRUGHOSODVPLQyJHQRORTXHFDX-
VDXQEORTXHRÀEULQROtWLFR7DPELpQVHREVHUYDUHGXFFLyQGH
ODVFRQFHQWUDFLRQHVSODVPiWLFDVGHSURWHtQDSRUORTXHVH
KDFRQYHUWLGRHQIDFWRUSURQyVWLFRGHPRUWDOLGDG38

/DLQKLELFLyQGHODVSURWHtQDVSURFRDJXODQWHVSRUHOHQGR-
WHOLRVHSURGXFHDWUDYpVGHORVVLVWHPDVDQWLFRDJXODQWHVÀ-
VLROyJLFRVODYtDGHODSURWHtQDHOVLVWHPDGHOD
DQWLWURPELQD,,,HOLQKLELGRUGHO)7(QODVHSVLVVHSURGXFH
XQDGLVPLQXFLyQGHHVWRVLQKLELGRUHVSRUFRQVXPRUHGXF-
FLyQGHVXVtQWHVLVRGHJUDGDFLyQPHGLDQWHHODVWDVDV/D
FRQVHFXHQFLDGHHOORHVODDSDULFLyQGHXQHVWDGRSURWURP-
EyWLFRFDUDFWHUL]DGRSRUXQDFRDJXODFLyQDFWLYDGDHLQVXÀ-
FLHQFLDGHORVVLVWHPDVLQKLELGRUHVGHODFRDJXODFLyQ
Disfunción endotelial
(OHQGRWHOLRHVHOyUJDQRGLDQDIXQGDPHQWDOGHODVHSVLV39
y
VHFDUDFWHUL]DSRUVHUPHWDEyOLFDPHQWHDFWLYRWHQHUOD
FDSDFLGDGSDUDUHVSRQGHUDGLYHUVRVHVWtPXORVÀVLROyJLFRV
SDWROyJLFRV(QWUHVXVIXQFLRQHVHVWiQHOPDQWHQLPLHQWRGH
ODKHPRVWDVLDODÁXLGH]GHODVDQJUH(OHQGRWHOLRGHVHP-
SHxDXQSDSHOFODYHHQODUHJXODFLyQGHODSUHVLyQDUWHULDO
HVIXQGDPHQWDOHQORVPHFDQLVPRVLQÁDPDWRULRV/DVFpOX-
ODVHQGRWHOLDOHVPDQWLHQHQXQGHOLFDGRHTXLOLEULRGHOWRQR
YDVFXODUODDGKHVLyQGHODVFpOXODVVDQJXtQHDVODFRDJXOD-
FLyQ3RUGLYHUVRVPHFDQLVPRVHOHQGRWHOLRHVFDSD]GH
FRQWURODUHOWRQRYDVRPRWRUPDQWHQHUODÁXLGH]GHODVDQ-
Figura 2 )LVLRSDWRORJtDGHODVHSVLV/DXQLyQGH3$03'$03DODV3$LQGXFHXQDDFWLYDFLyQGHHOHPHQWRVLQÁDPDWRULRVTXH
FRQOOHYDODSURGXFFLyQGHFLWRFLQDVODDFWLYDFLyQGHQHXWUyÀORVODDFWLYDFLyQGHOVLVWHPDGHOFRPSOHPHQWRGHODFDVFDGDGH
FRDJXODFLyQFDXVDUiGLVIXQFLyQRUJiQLFDHQFDVRGHXQDUHVSXHVWDGHVHTXLOLEUDGD,'FRDJXODFLyQLQWUDYDVFXODUGLVHPLQDGD
3$FpOXODSUHVHQWDGRUDGHDQWtJHQRV,/LQWHUOHXFLQD '$03V damage-associated molecular patterns; *6)*06)IDFWRU
HVWLPXODGRU GH FRORQLDV /3% LPS-binding protein; 3$03 pathogen-derived molecular patterns; 526 HVSHFLHV UHDFWLYDV GH
R[tJHQR 71)IDFWRUQHFURVLVWXPRUDO 7/5: toll-like receptors.
Medicina Intensiva 46S1 (2022):1-13 
JUHHLQWHUYHQLUHQODUHVSXHVWDLQÁDPDWRULD(QFRQGLFLRQHV
ÀVLROyJLFDVVHFDUDFWHUL]DIXQGDPHQWDOPHQWHSRUVXVSUR-
SLHGDGHVDQWLWURPEyWLFDVDQWLFRDJXODQWHVSURÀEULQROtWLFDV
DQWLDJUHJDQWHVSODTXHWDULDVRPRFRQVHFXHQFLDGHOD
HVWLPXODFLyQGHYDULDVFLWRFLQDV 71)Ş,/RWURV
PHGLDGRUHVLQÁDPDWRULRVFRPRHOFRPSOHPHQWRDFWLYDGR 
HVWDVSURSLHGDGHVHQGRWHOLDOHVVHYHQSURIXQGDPHQWH
DOWHUDGDVVHSURGXFHXQDWUDQVIRUPDFLyQHQGRWHOLDO
GHQRPLQDGD´DFWLYDFLyQGHOHQGRWHOLRµ(VWDVHFDUDFWHUL]D
SRUXQDVXSHUILFLHHQGRWHOLDOSURFRDJXODQWHXQEORTXHR
ÀEULQROtWLFRPHGLDGRSRUOLEHUDFLyQPDVLYDGHOLQKLELGRUGHO
DFWLYDGRUGHOSODVPLQyJHQRODH[SUHVLyQGHPROpFXODVGH
DGKHVLyQODSURGXFFLyQGHPHGLDGRUHVLQIODPDWRULRV
DJHQWHVYDVRDFWLYRV

Agregación plaquetaria
/DWURPERFLWRSHQLDHQODVHSVLVVHGHEHDGLYHUVRVIDFWRUHV
)XQGDPHQWDOPHQWHORVPHGLDGRUHVLQÁDPDWRULRVVXSULPHQ
ODSURGXFFLyQSODTXHWDULD2WURPHFDQLVPRHVHODXPHQWR
GHOFRQVXPRGHELGRDTXHODVSODTXHWDVSDUWLFLSDQHQOD
,'DOVHUDFWLYDGDVSRUODWURPELQDHOVLVWHPDGHFRPSOH-
PHQWRHOIDFWRUGHYRQ:LOOHEUDQG )Y: 42

Alteraciones hemodinámicas macrovasculares
y microvasculares en la sepsis y el shock
séptico
Alteraciones macrocirculatorias en la sepsis
$QLYHOPDFURKHPRGLQiPLFRVHKDFRQVLGHUDGRKLVWyULFD-
PHQWHTXHHOVKRFNVpSWLFRRFXUUHHQGLIHUHQWHVIDVHV(QOD
SULPHUDIDVHKDXQDKLSRYROHPLDFDXVDGDSULQFLSDOPHQWH
SRUSpUGLGDVUHODWLYDVGHYROXPHQGHELGDVDODXPHQWRGHOD
FDSDFLWDQFLDYHQRVDODGLVPLQXFLyQGHOYROXPHQHVWUHVDGR
TXHGHWHUPLQDHOUHWRUQRYHQRVR43
7DPELpQLQÁXHQHQOD
KLSRYROHPLDODVSpUGLGDVDEVROXWDVGHYROXPHQGHELGDVD
ÀHEUHGLVPLQXFLyQGHODLQJHVWDVDQJUDGRSpUGLGDVJDV-
WURLQWHVWLQDOHVHWF/DVHJXQGDIDVHHVODKLSHUGLQiPLFDGH
ODVHSVLVODWHUFHUDGLVIXQFLyQFDUGLDFDTXHFRQGXFHD
GLVIXQFLyQPXOWLRUJiQLFD44
DXQTXHODFDUGLRPLRSDWtDDVR-
FLDGDDVHSVLVVHSXHGHDGHODQWDUHVWDUSUHVHQWHGHVGHHO
inicio45

(VWDVIDVHVSXHGHQVHULQWHUFDPELDEOHVVLHPSUHFDUDFWH-
UL]DGDVSRUVHUXQSUREOHPDSULQFLSDOPHQWHGHFDUiFWHUGLV-
WULEXWLYR/DIDVHWHPSUDQDKLSHUGLQiPLFDVHFDUDFWHUL]D
SRUDOWRJDVWRFDUGLDFREDMDVUHVLVWHQFLDVSHULIpULFDVHKL-
SRYROHPLDUHODWLYD'HVSXpVKDXQDIDVHKLSRGLQiPLFDFRQ
EDMRJDVWRSREUHSHUIXVLyQGLVWDOGLVIXQFLyQPXOWLRUJi
nica46

OiVLFDPHQWHODHYDOXDFLyQPDFURKHPRGLQiPLFDVHKD
OOHYDGRDFDERPHGLDQWHFDWHWHUL]DFLyQGHODDUWHULDSXOPR-
QDU6LQHPEDUJRHOHPSOHRGHODHFRFDUGLRJUDItDKDPHMR-
UDGRVXVWDQFLDOPHQWHHVWDHYDOXDFLyQGLULJLpQGRODKDFLDXQ
PDRUGLQDPLVPR
$GHPiVGHODHYDOXDFLyQGHODIUDFFLyQ
GHHHFFLyQ )( HQODHFRFDUGLRJUDItDVHSRGUtDLQFOXLU
RWURVSDUiPHWURVGHFDUDDWLWXODUODÁXLGRWHUDSLDGHVRSRU-
WHYDVRDFWLYRRLQRWUySLFR48
6HSURSRQHTXHHVWRVVHDQ
DGHPiVGHOD)(GHOYHQWUtFXORL]TXLHUGR 9, HOiUHDGHO9,
HO97,DyUWLFR LQWHJUDOYHORFLGDGWLHPSRGHOÁXMRWUDQVDyU-
WLFR ODFRODSVDELOLGDGGHODYHQDFDYDLQIHULRUHOiUHDGH
ORVYHQWUtFXORVL]TXLHUGRGHUHFKRDOÀQDOGHODGLiVWROH
HYDOXDFLyQGHODIXQFLyQGLDVWyOLFDGHO9,PHGLDQWHHOHVWX-
GLRGHODVRQGDV(·H·6(VWRVMXQWRFRQSDUiPHWURVFOt-
QLFRVFRPRODIUHFXHQFLDFDUGLDFDODSUHVLyQDUWHULDO
VLVWyOLFDGLDVWyOLFDODGRVLVGHFDWHFRODPLQDVSXHGHQ
GLIHUHQFLDUIHQRWLSRVFDUGLRYDVFXODUHVPDFURKHPRGLQiPL-
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S0210569122001097 (3).pdf

  • 1. 0210-5691/ © 2022 Elsevier España, S.L.U. y SEMICYUC. Todos los derechos reservados. medicina intensiva www.medintensiva.org Medicina Intensiva 46S1 (2022):1-13 https://doi.org/ 10.1016/j.medin.2022.03.017 Volumen 34, Número 5. Junio-Julio 2010 Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias Federación Panamericana e Ibérica de Sociedades de Medicina Crítica y Terapia Intensiva www.elsevier.es/medintensiva www.semicyuc.org www.fepimcti.org Incluida en: Index Medicus/MEDLINE EMBASE/Excerpta Medica SCOPUS ISSN: 0210-5691 Editorial Diagnóstico precoz del fracaso renal agudo M. Rodríguez López y A. Roglan Piqueras 291 Originales Concordancia en pacientes críticos entre las ecuaciones diseñadas para la estimación del filtrado glomerular y el aclaramiento de creatinina en orina de 24h G. Seller-Pérez, M.E. Herrera-Gutiérrez, E. Banderas-Bravo, R. Olalla-Sánchez, R. Lozano-Sáez y G. Quesada-García 294 Sincronía auriculo-ventricular en pacientes portadores de marcapasos con estimulación VDD. Estudio descriptivo de un periodo de 14 años A. Canabal Berlanga, M. Sánchez Casado, J.M. Díaz Borrego, A. Raigal Caño y P. Sánchez Rodríguez 303 Síndrome de Distrés Respiratorio Agudo, durante la pandemia de Influenza A H1N1 2009 en Ecuador G. Paredes y C. Cevallos 310 Puesta al día: El enfermo crítico con infección grave Neumonía asociada a la ventilación mecánica E. Diaz, L. Lorente, J. Valles y J. Rello 318 Debates en Medicina Intensiva: Empleo de Descontaminación Digestiva Selectiva Pro descontaminación selectiva M. Sánchez García 325 Descontaminación: un tratamiento sin indicaciones E. Palencia Herrejón y P. Rico Cepeda 334 Revisión Hemofiltración de alto volumen en shock séptico C.M. Romero, P. Downey y G. Hernández 345 Nota clínica Hiperinfección por Strongyloides stercoralis J. Llagunes, E. Mateo, J.J. Peña, P. Carmona y J. de Andrés 353 Cartas al Director Administración accidental de dosis tóxicas de adrenalina intravenosa a un lactante de 5 meses M.S. Holanda Peña, J.L. Teja Barbero, J. Velasco Montes y M. López Sánchez 357 Diagnóstico tardío de un caso de porfiria aguda intermitente en una unidad de cuidados intensivos A.J. Betbesé, L. Zapata, C. Martínez-Brú y C. Herrero 358 Muerte encefálica aparente tras sobredosis de baclofén R. Salas De Zayas, F. San José Pacheco, C. Dolera Moreno y L. Zoila Peiró 359 Imágenes en Medicina Intensiva Embolia aérea pulmonar como complicación de punción venosa central J. Bayón, M. Martín e I. Lozano 360 Actividad acreditada en base a la encomienda de gestión concedida por los Ministerios de Educación, Cultura y Deporte y de Sanidad y Consumo ciales de Médicos con 2,1 créditos equivalentes a 10 horas lectivas. www.formacion.elsevier.es/medicinaintensiva COMISIÓN DE FORMACIÓN CONTINUADA DEL SNS PALABRAS CLAVE Sepsis; Shock séptico; Respuesta LQÁDPDWRULD Citocina; Endotelio; Endotoxina; 0LFURFLUFXODFLyQ Resumen La sepsis y el shockVpSWLFRVRQHOUHVXOWDGRGHXQDUHVSXHVWDLQDGHFXDGDGHOKXpVSHG DXQDLQIHFFLyQORTXHSURGXFHGLVIXQFLyQRUJiQLFD/DSURJUHVLyQGHHVWDDIHFFLyQVHPDQLÀHVWD SRUODDSDULFLyQGHHVWDGLRVFOtQLFRVVXFHVLYRVGHULYDGRVGHODUHVSXHVWDLQÁDPDWRULDVLVWpPLFD VHFXQGDULDDODDFWLYDFLyQGHGLIHUHQWHVPHGLDGRUHVLQÁDPDWRULRVTXHFRQGXFHQDODGLVIXQFLyQ RUJiQLFD+DJUDQFDQWLGDGGHHYLGHQFLDVREUHHOSDSHOGHODHQGRWR[LQDHQODSDWRJpQHVLVGHOD VHSVLVHOSDSHOIXQGDPHQWDOTXHWLHQHHQHOLQLFLRGHODUHVSXHVWDLQÁDPDWRULDHQODVHSVLVFDX- VDGDSRUPLFURRUJDQLVPRV*UDPQHJDWLYRV/DDFWLYDFLyQGHODFDVFDGDGHFRDJXODFLyQHQORVSD- FLHQWHVFRQVHSVLVHVSDUWHGHODUHVSXHVWDLQPXQLWDULDDGDSWDWLYDGHOKXpVSHGDODLQIHFFLyQ(O HQGRWHOLRHVHOEODQFRSULQFLSDOHQODVHSVLVHOFXDOHVPHWDEyOLFDPHQWHDFWLYRSXHGHUHVSRQGHU DGLYHUVRVHVWtPXORVÀVLROyJLFRVSDWROyJLFRV DFWLYDFLyQHQGRWHOLDO $GDSWDUORVWUDWDPLHQWRVD SDFLHQWHVHVSHFtÀFRVHVXQDHVWUDWHJLDREOLJDGDSHUVRQDOL]DGDSDUDFHQWUDUVHHQODFRKHUHQFLD KHPRGLQiPLFD/DLQYHVWLJDFLyQIXWXUDGHEHUHVSRQGHUDVLODVHVWUDWHJLDVGLULJLGDVDUHFOXWDU PLFURFLUFXODFLyQSXHGHQPHMRUDUORVGHVHQODFHVFOtQLFRVGHORVSDFLHQWHV ‹(OVHYLHU(VSDxD6/86(0,87RGRVORVGHUHFKRVUHVHUYDGRV Pathophysiology of septic shock Abstract 6HSVLVDQGVHSWLFVKRFNUHVXOWIURPDQLQDGHTXDWHKRVWUHVSRQVHWRDQLQIHFWLRQ ZKLFKFDXVHVRUJDQGVIXQFWLRQ7KHSURJUHVVLRQRIWKLVFRQGLWLRQLVPDQLIHVWHGEWKHRFFX- UUHQFHRIVXFFHVVLYHFOLQLFDOVWDJHVUHVXOWLQJIURPWKHVVWHPLFLQÁDPPDWRUUHVSRQVHVHFRQ- GDUWRWKHDFWLYDWLRQRIGLIIHUHQWLQÁDPPDWRUPHGLDWRUVOHDGLQJWRRUJDQGVIXQFWLRQ7KHUH LVDKLJKEXUGHQRIHYLGHQFHRQWKHUROHRIHQGRWR[LQLQWKHSDWKRJHQHVLVRIVHSVLVDQGLWVFUXFLDO UROHLQWULJJHULQJWKHLQÁDPPDWRUUHVSRQVHLQVHSVLVFDXVHGEJUDPQHJDWLYHEDFWHULD7KH FRDJXODWLRQFDVFDGHDFWLYDWLRQLQVHSVLVSDWLHQWVLVSDUWRIWKHKRVW·VDGDSWLYHLPPXQHUHVSRQVH WRLQIHFWLRQ7KHHQGRWKHOLXPLVWKHPDLQWDUJHWLQVHSVLVZKLFKLVPHWDEROLFDOODFWLYHDQGFDQ $XWRUSDUDFRUUHVSRQGHQFLD Correo electrónico:UIHUUHU#YKHEURQQHW 5)HUUHU 5(68,7$,Ð1'(/3$,(17(216(36,6SHOCK6e37,2 Fisiopatología del shock séptico Luis Chiscano-Camóna,b,c , Erika Plata-Menchacaa,b , Juan Carlos Ruiz-Rodrígueza,b,c y Ricard Ferrera,b,c, * a Servicio de Medicina Intensiva, Hospital Universitario Vall d’Hebron, Barcelona, España b Grupo de Investigación Sepsis Organ Dysfunction and Resuscitation (SODIR), Vall d’Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d’Hebron, Barcelona, España c Departament de Medicina. Universitat Autònoma de Barcelona. Barcelona. España KEYWORDS Sepsis; 6HSWLFVKRFN ,QÁDPPDWRU UHVSRQVH WRNLQH (QGRWKHOLXP Endotoxin; 0LFURFLUFXODWLRQ
  • 2. /KLVFDQR(3ODWD0HQFKDFD-5XL]5RGUtJXH]HWDO UHVSRQGWRYDULRXVSKVLRORJLFDODQGSDWKRORJLFDOVWLPXOL$GDSWLQJWUHDWPHQWVWRVSHFLÀFSD- WLHQWVZLOOEHDPDQGDWRUDQGSHUVRQDOL]HGVWUDWHJWRIRFXVRQ´KHPRGQDPLFFRKHUHQFHµ )XWXUHUHVHDUFKVKRXOGDQVZHUZKHWKHUVWUDWHJLHVWRUHFUXLWPLFURFLUFXODWLRQFDQLPSURYHFOLQL- FDORXWFRPHV ‹(OVHYLHU(VSDxD6/86(0,8$OOULJKWVUHVHUYHG Introducción La sepsis y el shockVpSWLFRVRQHOUHVXOWDGRGHODUHVSXHVWD LQDGHFXDGDGHOKXpVSHGDXQDLQIHFFLyQTXHRFDVLRQDGLV- IXQFLyQGHXQRRPiVyUJDQRV1 /DUHVSXHVWDLQÁDPDWRULDHQ ODPDRUtDGHORVLQGLYLGXRVHVDGDSWDWLYDFRQWULEXHD FRQWURODUODLQIHFFLyQ6LQHPEDUJRHQODVHSVLVVHSURGXFH XQGHVHTXLOLEULRHQWUHORVPHFDQLVPRVSURLQÁDPDWRULRV DQWLLQÁDPDWRULRV/DSURJUHVLyQGHHVWDFRQGLFLyQVHFDUDF- WHUL]DSRUODDSDULFLyQVXFHVLYDGHHVWDGLRVFOtQLFRVTXHVRQ HOUHVXOWDGRGHODUHVSXHVWDLQÁDPDWRULDVLVWpPLFDVHFXQGD- ULDDODDFWLYDFLyQGHGLIHUHQWHVPHGLDGRUHVLQÁDPDWRULRV TXHFRQGXFHQDGLVIXQFLyQRUJiQLFD2 (ÀJXUD (VWRLQFOXH GLIHUHQWHVSURFHVRVÀVLROyJLFRVFRPRODDFWLYDFLyQGHGLIH- UHQWHVOtQHDVFHOXODUHV PRQRFLWRVPDFUyIDJRVQHXWUyÀORV FpOXODVHQGRWHOLDOHVSODTXHWDV ODSURGXFFLyQORFDOVLVWp- PLFDGHFLWRFLQDVODHVWLPXODFLyQGHODFDVFDGDGHSURWHt- QDVSODVPiWLFDV FRPRHOVLVWHPDGHOFRPSOHPHQWR OD DFWLYDFLyQGHODVYtDVGHFRDJXODFLyQLQWUtQVHFD VLVWHPDGH FRQWDFWR H[WUtQVHFDHOVLVWHPDÀEULQROtWLFRODSURGXF- FLyQGHPHGLDGRUHVOLStGLFRVODDFWLYDFLyQGHODYtDGHO y[LGRQtWULFR 12 ODSURGXFFLyQGHUDGLFDOHVOLEUHVODHVWL- PXODFLyQGHORVOLQIRFLWRV%7VXVSURGXFWRVIHQyPHQRV GHSURWHROLVLV3 HQWUHRWURV4 Figura 1 (YROXFLyQGHODVHSVLVRQODLQWHUDFFLyQGH3$03'$03FRQODFpOXODSUHVHQWDGRUDGHDQWtJHQRVVHLQLFLDODFDVFDGD LQÁDPDWRULDGHODLQPXQLGDGLQQDWDDGDSWDWLYD/DLQÁDPDFLyQFDXVDGDxRWLVXODUVHFXQGDULDPHQWHGLVIXQFLyQRUJiQLFD(Q DOJXQRVSDFLHQWHVVHJHQHUDXQHVWDGRGHLQPXQRSDUiOLVLVFDUDFWHUL]DGRSRUODDSDULFLyQGHLQIHFFLRQHVQRVRFRPLDOHVRSRUWXQLVWDV UHDFWLYDFLRQHVYLUDOHVGHELGRDODDSRSWRVLVGHOWHMLGRLQPXQLWDULRODLQFDSDFLGDGUHODWLYDGHODVFpOXODV7 '$03 damage- associated molecular patterns; 3$03pathogen-derived molecular patterns; 7/5 toll-like receptor.
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  • 5. Medicina Intensiva 46S1 (2022):1-13 5 Tabla 1 3ULQFLSDOHVPHGLDGRUHVLQÁDPDWRULRVHQODVHSVLV(cont.) Ð[LGRQtWULFR 9DVRGLODWDGRU FRDJXORSDWtD (QGRWHOLRYDVFXODU6H VLQWHWL]DDSDUWLUGHO QLWUyJHQRGHODJXDQLGLQD WHUPLQDOGHODPLQRiFLGR /DUJLQLQDSRUODDFFLyQ GHXQD12VLQWHWDVD 12V SURGXFLHQGR12 /FLWUXOLQD (O12DOLQKLELUODDGKHVLyQSODTXHWDULDDOHQGRWHOLR YDVFXODUGDxDGRFRQWULEXHDHYLWDUHOSDVRLQLFLDOTXHOOHYD DODDFWLYDFLyQFRQHOORODDJUHJDFLyQROLEHUDFLyQ SODTXHWDULD8QDSURGXFFLyQH[FHVLYDGH12FDXVDOD UHODMDFLyQGHODVDUWHULDVXQDSUHVLyQVDQJXtQHD H[FHVLYDPHQWHEDMD 3URVWDJODQGLQDV 'LYHUVR HQIXQFLyQ de tipos de SURVWDJODQGLQDV SURVWDFLFOLQD,2 3*,2 SURVWDJODQGLQD E2 3*(2) y SURVWDJODQGLQD )Ş 3*)Ş) 6HVLQWHWL]DQDSDUWLU GHORViFLGRVJUDVRV HVHQFLDOHVSRUODDFFLyQ GHGLIHUHQWHVHQ]LPDV FRPRFLFORR[LJHQDVDV OLSRR[LJHQDVDVHO FLWRFURPR3 SHUR[LGDVDVHWF /DVSURVWDJODQGLQDVWLHQHQHIHFWRHQODUHVLVWHQFLDYDVFXODU FRUWLFDOUHQDOSURGXFHXQDXPHQWRGHOÁXMRVDQJXtQHR FRUWLFDOUHQDOHOFRQVLJXLHQWHDXPHQWRGHOYROXPHQ LQWUDFHOXODUGLVPLQXFLyQGHODUHVLVWHQFLDSHULIpULFD 'HHVWDPDQHUDMXQWRFRQODKRUPRQD $'+ y la DOGRVWHURQD UHJXODQYtDKRUPRQDOODSUHVLyQDUWHULDO,QWHUYLHQHQ HQODUHVSXHVWDLQÁDPDWRULDYDVRGLODWDFLyQDXPHQWR GHODSHUPHDELOLGDGGHORVWHMLGRVTXHIDFLOLWDHOSDVR de los leucocitosDQWLDJUHJDQWHSODTXHWDULRHVWtPXORGH ODVWHUPLQDFLRQHVQHUYLRVDVGHOGRORUHWF Endotoxina o OLSRSROLVDFiULGR /36 3URLQÁDPDWRULR 'LYHUVRVFRPSRQHQWHVGH ODSDUHGGHODVEDFWHULDV *UDPSRVLWLYDV SHSWLGRJOXFDQRV PXUDPLOGLSpSWLFRV iFLGROLSRWHLFRLFR H[RWR[LQDV H[RWR[LQD$ de Pseudomonas aeruginosa7667 GHOVtQGURPHGHshock Wy[LFRHVWDÀORFyFLFR WR[LQDHULWURJpQLFDGHO HVWUHSWRFRFRJUXSR$ DQWtJHQRVULFNHWWVLDOHV YtULFRVI~QJLFRV OLSRDUDELQRPDQDQR SXHGHQGHVHQFDGHQDU ODUHVSXHVWDLQÁDPDWRULD (OLQGXFWRUGHODUHVSXHVWDLQÁDPDWRULDPHMRUFRQRFLGR HVODHQGRWR[LQDROLSRSROLVDFiULGR /36 GHODVEDFWHULDV *UDPQHJDWLYDV/DDGPLQLVWUDFLyQGH/36HQ H[SHULPHQWDFLyQDQLPDOHLQGLYLGXRVVDQRVUHSURGXFHOD PDRUSDUWHGHODVDOWHUDFLRQHVKHPRGLQiPLFDVGHOshock VpSWLFRODGLVIXQFLyQPXOWLRUJiQLFD(QHOVLVWHPD FDUGLRYDVFXODULQFUHPHQWDODIUHFXHQFLDFDUGLDFDHOtQGLFH FDUGLDFRGLVPLQXHODVUHVLVWHQFLDVYDVFXODUHVVLVWpPLFDV KDVWDODKLSRWHQVLyQ$QLYHOPLFURYDVFXODUODHQGRWR[LQD DFWLYDODFRDJXODFLyQORVVLVWHPDVGHFRQWDFWR GHOFRPSOHPHQWRÀEULQROtWLFR$FW~DHQHOHQGRWHOLR LQKLELHQGRODDFFLyQGHDQWLFRDJXODQWHVHQGyJHQRV SURGXFLHQGRUDGLFDOHVOLEUHVHLQFUHPHQWDQGRODSURGXFFLyQ GH12$GHPiVDFWLYDORVPDFUyIDJRVLQGXFLHQGRODVtQWHVLV GHFLWRFLQDVORVQHXWUyÀORVFDXVDQGROHVLyQHQGRWHOLDO PHGLDQWHODSURGXFFLyQGHDQLRQHVVXSHUy[LGRHQ]LPDV SURWHROtWLFDV PDGR TXHLQPRYLOL]DQDOSDWyJHQRHVWLPXODQRWUDVVXV- WDQFLDVLQÁDPDWRULDV(VWRVSURFHVRVFRQOOHYDQODDFWLYDFLyQ GHODFDVFDGDGHODFRDJXODFLyQ18 (ÀJXUD 'HKHFKRORV SDFLHQWHVVpSWLFRVFRQXQDHYROXFLyQFOtQLFDGHVIDYRUDEOH SUHVHQWDQXQDXPHQWRGHODVUHGHVGHQHXWUyÀORWLVXODU19 (OVLVWHPDGHOFRPSOHPHQWRWDPELpQHVWiLPSOLFDGRHQOD ÀVLRSDWRORJtDGHODVHSVLV7DQWRODIUDFFLyQD D FRPR VXUHFHSWRU D5 VRQDFWRUHVUHOHYDQWHV7UDVODXQLyQFRQ ORVQHXWUyÀORVHVWHHOHPHQWRGHOVLVWHPDGHFRPSOHPHQWR SHQHWUDHQODFpOXODGRQGH3$03'$03LQGXFHQODUHG QHXWURItOLFDTXHJHQHUDGDxRR[LGDWLYRFRDJXORSDWtDFD- UDFWHUL]DGDSRUXQHVWDGRSURWURPEyWLFREORTXHRÀEULQROt- tico20 8QDDFWLYDFLyQH[FHVLYDGHDFDXVDDSRSWRVLVGHORV OLQIRFLWRVGLVIXQFLyQGHORVQHXWUyÀORV21 ([LVWHXQDKHWHURJHQHLGDGRYDULDELOLGDGLQWHULQGLYLGXDO FRQVLGHUDEOHHQODUHVSXHVWDLQÁDPDWRULDGHVFULWDTXHVH PRGXODSRUYDULRVIDFWRUHVFRPRODKLSRJDPPDJOREXOLQH- PLD22 ORTXHPRWLYDGLÀFXOWDGHVHQHOGLDJQyVWLFRHOWUDWD- PLHQWR23 %HUPHMR0DUWLQHWDOKDQGHVFULWRKDVWD LQPXQRIHQRWLSRVGLVWLQWRVDVRFLDGRVFRQODLQPXQRVXSUH- VLyQHOGHVHTXLOLEULRLQPXQROyJLFRHQODVHSVLV/RVIHQRWL- SRVTXHGHVFULEHQVRQODVDOWHUDFLRQHVFXDQWLWDWLYDV FXDOLWDWLYDVHQODV3$ORVOLQIRFLWRV%7ODVFpOXODV1. y ORVQHXWUyÀORV7DPELpQGHVFULEHQDOWHUDFLRQHVHQODSUR- SRUFLyQGHODVFpOXODV7UHJXODGRUDVHOLQFUHPHQWRHQOD H[SUHVLyQGHODSURWHtQDprogrammed cell death protein-1 3' KLSRJDPPDJOREXOLQHPLDKLSHUFLWRFLQHPLDGLVIXQ- FLyQGHOVLVWHPDGHFRPSOHPHQWRHOLPSRUWDQWHSDSHOGH ODVUHGHVH[WUDFHOXODUHVGHQHXWUyÀORHQHOGHVDUUROORGHOD LQIHFFLyQ24 /RVDXWRUHVSURSRQHQTXHVXHVWXGLRFRQGX]FDD XQWUDWDPLHQWRSHUVRQDOL]DGR(VWH~OWLPRDVSHFWRQRVH WUDWDHQHVWDUHYLVLyQ Endotelio y coagulopatía en la sepsis /DDFWLYDFLyQGHODFDVFDGDGHODFRDJXODFLyQHQHOSDFLHQWH VpSWLFRVHUHFRQRFHFRPRSDUWHGHXQDUHVSXHVWDLQPXQLWD- ULDDGDSWDWLYDGHOKXpVSHGDODLQIHFFLyQ25 6LQHPEDUJROD FRDJXODFLyQLQWUDYDVFXODUGLVHPLQDGD ,' TXHSXHGHDSD- UHFHUHQSDFLHQWHVFRQVHSVLVHVHOUHVXOWDGRGHXQDDFWLYD- FLyQGHVPHGLGDGHOHWpUHDGHODFRDJXODFLyQ26 6HWUDWDXQ VtQGURPHDGTXLULGRFDUDFWHUL]DGRSRUDFWLYDFLyQGHORVIDF- WRUHVGHODFRDJXODFLyQRULJLQDGRVDUDt]GHXQGDxRHQHO
  • 6. /KLVFDQR(3ODWD0HQFKDFD-5XL]5RGUtJXH]HWDO OHFKRPLFURYDVFXODUTXHSXHGHOOHJDUDFDXVDUGLVIXQFLyQ RUJiQLFDGHSHQGLHQGRGHVXPDJQLWXG $OFDQ]DXQDJUDQ YDULHGDGGHHQWLGDGHVFOtQLFDVFRQIHQyPHQRVKHPRUUiJL- cos en etapas iniciales28 DOWHUDFLRQHVHQODVSUXHEDVGHFRD- JXODFLyQRLVTXHPLDGLVWDOGHODVH[WUHPLGDGHVSRU IHQyPHQRVWURPEyWLFRV29 6RQORVIDFWRUHVFODYHTXHFRQ- WULEXHQHQOD,'ODDFWLYDFLyQGHODFDVFDGDGHODFRDJX- ODFLyQODDJUHJDFLyQSODTXHWDULDHOGDxRHQGRWHOLDO Activación de la cascada de coagulación EORTXHRÀEULQROtWLFR /DVHSVLVVHFDUDFWHUL]DSRUXQHVWDGRSURWURPEyWLFRMXQWR FRQEORTXHRÀEULQROtWLFRDPERVVRQORVPHFDQLVPRVIXQ- GDPHQWDOHVGHOD,'+DXQDVHULHGHPHGLDGRUHVLQÁDPD- WRULRVTXHSURPXHYHQODDFWLYDFLyQGHODWURPELQDHQODYtD FRP~QGHODFRDJXODFLyQFRPRSDUWHGHODUHVSXHVWDGHO KXpVSHGDODLQIHFFLyQ30 (OIDFWRUWLVXODU )7 SRUVXSDUWH FRPRDFWLYDGRUGHODYtDH[WUtQVHFDVHH[SUHVDHQPDFUyID- JRVPRQRFLWRVFpOXODVHQGRWHOLDOHV31 /DDFFLyQFRQMXJDGD GH3$03'$03HVHOIDFWRUGHWHUPLQDQWHSDUDHOLQLFLRGHO SURFHVR$GHPiVLQWHUYLHQHQRWURVPHGLDGRUHVKXPRUDOHV FRPR,/,/71)ŞHODVWDVDFDWHSVLQD*HOVLVWHPDGHO FRPSOHPHQWRTXHWDPELpQVRQIDFLOLWDGRUHVGHOSURFHVR32 ,QFOXVRODVUHGHVH[WUDFHOXODUHVGHQHXWUyILORVDFWLYDGRV WDPELpQHVWiQLPSOLFDGDV33 1RVHSURGXFHH[FOXVLYDPHQWHXQDDFWLYDFLyQGHODFDVFD- GDGHODFRDJXODFLyQVLQRGHORVHOHPHQWRVTXHODUHJXODQ FRPRHOVLVWHPDILEULQROtWLFRTXHVHDOWHUDQHQWUDQHQ GLVIXQFLyQ6HKDOODQYDORUHVHOHYDGRVGHOLQKLELGRUWLVXODU GHSODVPLQyJHQRTXHSURGXFHQXQYLUDMHDXQHVWDGRGH WURPERÀOLDHQOD,'34 'HKHFKRVXFRQFHQWUDFLyQSODVPi- WLFDVHKDUHODFLRQDGRFRQGLVIXQFLyQRUJiQLFDPRUWDOLGDG en la sepsis35 7DPELpQKDXQDUHJXODFLyQDODEDMDGHORV LQKLELGRUHVGHODWURPELQD36 HOSODVPLQyJHQR HLQFUHPHQ- WRGHOLQKLELGRUGHODFWLYDGRUGHOSODVPLQyJHQRORTXHFDX- VDXQEORTXHRÀEULQROtWLFR7DPELpQVHREVHUYDUHGXFFLyQGH ODVFRQFHQWUDFLRQHVSODVPiWLFDVGHSURWHtQDSRUORTXHVH KDFRQYHUWLGRHQIDFWRUSURQyVWLFRGHPRUWDOLGDG38 /DLQKLELFLyQGHODVSURWHtQDVSURFRDJXODQWHVSRUHOHQGR- WHOLRVHSURGXFHDWUDYpVGHORVVLVWHPDVDQWLFRDJXODQWHVÀ- VLROyJLFRVODYtDGHODSURWHtQDHOVLVWHPDGHOD DQWLWURPELQD,,,HOLQKLELGRUGHO)7(QODVHSVLVVHSURGXFH XQDGLVPLQXFLyQGHHVWRVLQKLELGRUHVSRUFRQVXPRUHGXF- FLyQGHVXVtQWHVLVRGHJUDGDFLyQPHGLDQWHHODVWDVDV/D FRQVHFXHQFLDGHHOORHVODDSDULFLyQGHXQHVWDGRSURWURP- EyWLFRFDUDFWHUL]DGRSRUXQDFRDJXODFLyQDFWLYDGDHLQVXÀ- FLHQFLDGHORVVLVWHPDVLQKLELGRUHVGHODFRDJXODFLyQ Disfunción endotelial (OHQGRWHOLRHVHOyUJDQRGLDQDIXQGDPHQWDOGHODVHSVLV39 y VHFDUDFWHUL]DSRUVHUPHWDEyOLFDPHQWHDFWLYRWHQHUOD FDSDFLGDGSDUDUHVSRQGHUDGLYHUVRVHVWtPXORVÀVLROyJLFRV SDWROyJLFRV(QWUHVXVIXQFLRQHVHVWiQHOPDQWHQLPLHQWRGH ODKHPRVWDVLDODÁXLGH]GHODVDQJUH(OHQGRWHOLRGHVHP- SHxDXQSDSHOFODYHHQODUHJXODFLyQGHODSUHVLyQDUWHULDO HVIXQGDPHQWDOHQORVPHFDQLVPRVLQÁDPDWRULRV/DVFpOX- ODVHQGRWHOLDOHVPDQWLHQHQXQGHOLFDGRHTXLOLEULRGHOWRQR YDVFXODUODDGKHVLyQGHODVFpOXODVVDQJXtQHDVODFRDJXOD- FLyQ3RUGLYHUVRVPHFDQLVPRVHOHQGRWHOLRHVFDSD]GH FRQWURODUHOWRQRYDVRPRWRUPDQWHQHUODÁXLGH]GHODVDQ- Figura 2 )LVLRSDWRORJtDGHODVHSVLV/DXQLyQGH3$03'$03DODV3$LQGXFHXQDDFWLYDFLyQGHHOHPHQWRVLQÁDPDWRULRVTXH FRQOOHYDODSURGXFFLyQGHFLWRFLQDVODDFWLYDFLyQGHQHXWUyÀORVODDFWLYDFLyQGHOVLVWHPDGHOFRPSOHPHQWRGHODFDVFDGDGH FRDJXODFLyQFDXVDUiGLVIXQFLyQRUJiQLFDHQFDVRGHXQDUHVSXHVWDGHVHTXLOLEUDGD,'FRDJXODFLyQLQWUDYDVFXODUGLVHPLQDGD 3$FpOXODSUHVHQWDGRUDGHDQWtJHQRV,/LQWHUOHXFLQD '$03V damage-associated molecular patterns; *6)*06)IDFWRU HVWLPXODGRU GH FRORQLDV /3% LPS-binding protein; 3$03 pathogen-derived molecular patterns; 526 HVSHFLHV UHDFWLYDV GH R[tJHQR 71)IDFWRUQHFURVLVWXPRUDO 7/5: toll-like receptors.
  • 7. 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