"The Human Face of Big Data", Crystal Valentine, VP of Technology Strategy at MapR Watch more from Data Natives Tel Aviv 2016 here: http://bit.ly/2hw1MY0 Visit the conference website to learn more: http://telaviv.datanatives.io/ Follow Data Natives: https://www.facebook.com/DataNatives https://twitter.com/DataNativesConf Stay Connected to Data Natives by Email: Subscribe to our newsletter to get the news first about Data Natives 2017: http://bit.ly/1WMJAqS About the Author: Crystal Valentine is Vice President of Technology Strategy at MapR. She has an extensive background in big data research and practice. Before joining MapR, she was a professor of computer science at Amherst College. She is the author of several academic publications in the areas of algorithms, high-performance computing, and computational biology and holds a patent for Extreme Virtual Memory. As a former consultant at Ab Initio Software working with Fortune 500 companies to design and implement high-throughput, mission-critical applications and as a tech expert consulting for equity investors focused on technology, she has developed significant business experience in the enterprise computing industry. Dr. Valentine received her doctorate in Computer Science from Brown University and was a Fulbright Scholar to Italy.

1. © 2016 MapR Technologies
Crystal Valentine, PhD
VP of Technology Strategy
The Human Face of Big Data

2. © 2016 MapR Technologies
Human Welfare

3. India
1.3 billion residents
640,000 villages
22 official languages
$40 billion per year on subsidies
40% leakage

4. Subsidies as % of Government Expenditure
0
2
4
6
8
10
12
14
16
18
20
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

5. Largest Biometric Database in the World
PEOPLE
20 BILLION
BIOMETRICS

6. Massive NoSQL Database Application
1M registrations (Trillions of matches) / day
5 TB incremental data / day
100M+ authentications / day
200 ms response
0.0001 false positive rate
Billion+ audit records per day

7. Always-on high availability
● Mirroring and backup
across DCs
● Strong consistency for
update and insert
DC #1
Gurgaon
DC #3
Bangalore
Regional
Backup #2
Regional
Backup #4

8. Broad Application Support through Open APIs
Enrollment Services (40k enrollment stations)
Authentication Services
Fraud detection frameworks
Administrative Services
Analytics and Reporting Services
Logistics services
Contact Center

9. Impact
>1 billion Aadhaars issued
95% of adults in India
500K-700K new enrollees everyday
200 milliseconds to verify an ID
240 million bank accounts
122 million LPG consumers
113 million ration cards

10. © 2016 MapR Technologies
Cancer Genomics

11. Human Genome Sequencing
3 Billion base pairs
25,000 Genes
Massively parallel WGS pipeline
Sequence over 10k Gbp/week

13. Cancer: a complex disease
2012:
• 14.1M new cases
• 8.2M deaths
1 tumor ~ 100 billion cells
Characterized by pathway disruption

14. Interaction Network
Vertices = genes
Edges = interactions
“pathway” = subnetwork

15. Finding Mutated Pathways
Network
G = (V,E)
Binary mutation
matrix
Patients
Genes
= mutated
= not mutated
+ =
Connected
subnetworks mutated
in significant number
of patients
*TCGA (Nature, 2011 and NEJM, 2013)

16. Individualized Treatment
Clinical / Lab
Genomic /
Network
Analysis
Lifestyle /
Phenotypic /
Health sensors
Electronic Medical Records
Literature /
Research

17. Collaboration + Innovation
Susan G. Komen
Big Data for Breast Cancer (BD4BC) Initiative
• Pledged to reduce mortality rate 50% in next decade
• Partnerships in 50+ countries
• Extensive network of researchers, health care providers,
patient advocates, clinics
• Leverage shared/public data sets + big data technologies

18. © 2016 MapR Technologies
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