A leading health scientist explains the 7 interconnected reasons why some people do age more slowly and live longer. in just 25 short slides,he shows how to switch on ‘good’ genes, neutralise the threats of age related illness and extend your years of good health.

1. The 7 discoveries
that will enable you
to live healthier
for longer.
Dr Paul Clayton:
Former Chair of the Forum on
Food and Health at the Royal
Society of Medicine.

2. “The so-called ‘age-related’ diseases take
from 10 to 20 years to surface as overt,
debilitating, life-threatening illnesses – heart
disease, stroke, cancer, diabetes, dementia.
That’s equally true of life-diminishing
conditions like arthritis, chronic tiredness and
erectile dysfunction.
At that point pharmaceutical treatment is
largely treating the symptoms not the causes.
If you want to be healthier for longer, the
time to take positive preventative action is
in your early 50’s or even before.
Thanks to recent discoveries we now know
the best way to slow ageing and maximise
the chance of continuing full health. I call
them ‘The 7 Pillars of Health’
Preventative Healthcare is the key

3. Certain nutrients can upregulate or turn on
‘good’ genes – like tumour suppressor genes.
And others can down-regulate or turn off
‘bad’ genes – such as oncogenes which have
the potential to cause cancer.
It’s called ‘gene expression’, part of a new
science called Epigenetics. There are foods
and nutrients you can include in your diet
that can express genes to promote health
and even slow biological ageing.
One of the leading researchers in this area is
Dr Cynthia Kenyon working at Cambridge
University on ageing mechanisms. She says:
“The idea that ageing was subject to control
was completely unexpected”
1. Turn on ‘good’ genes, turn off ‘bad’ genes

4. A study at the University of California at San
Francisco showed that hundreds of genes in
people who were put on a largely plant
based diet were modified, leading to a lower
cancer and heart disease risk.
Plant derived nutrients that up-regulate
genes to promote health include the
polyphenols in green tea , lycopene, lutein
and genistein, which is a compound in soy.
Other nutrients that have been shown to
positively activate gene expression are:
Choline, folic acid, B6 and B12, a B vitamin
called betaine, vitamin D3 and minerals that
include zinc and selenium.
Nutrients that encourage gene expression: Betaine, B6, B12, folic acid, vitamin
D, zinc, selenium, lycopene, lutein, green tea polyphenols and genistein.
Promoting gene expression

5. Chromosomes are condensed rods of DNA
and have 4 ‘arms’. At the end of each arm is a
telomere – a tiny protective ‘cap’ often
likened to the plastic end of a shoe lace.
Each time a cell divides to make a new copy
the telomere gets fractionally shorter. When
the end of the telomere is finally reached,
the cell dies. So scientists believe the length
of your telomeres may be a good marker of
biological ageing and mortality.
Research shows that the rate at which
telomeres become shorter can be slowed
down with an anti-oxidant and anti-
inflammatory rich diet .
2. Slow down the shortening of telomeres
Anti-inflammatory and anti-oxidant nutrients: Omega 3, vitamins C and E,
beta carotene, curcumin and polyphenols in green tea and grapeseed extract

6. Your body is made of organs, organs are
made of tissue and tissues are made of cells.
You make billions of new cells every day!
Since cells are constantly dying and being
replaced, the foundation of a healthy body is
to ensure every part of every new cell has
the nutrients it needs to regenerate itself and
function at peak effectiveness. Other
nutrients help slow cell breakdown.
We talk about ‘age related’ illness like heart
disease, diabetes, dementia and chronic
tiredness, but the passing of the years has
much less effect than sub-optimal nutrition
and lifestyle.
3. Build healthy cells

7. Encasing each cell is a membrane made up of
proteins, cholesterol and fatty acid. These
fats give the membrane its flexibility and
structure.
If your diet has insufficient high quality fatty
acids in it, the membrane has to build itself
with low quality fats. It becomes stiffer, less
permeable and less able to allow essential
nutrients in or wastes out.
Omega 3 fish oils help build healthy, flexible
cell membranes. Some 50% of the eye’s
photoreceptors are made up of Omega 3 oils
as are over 40% of brain cell fats.
As the brain is high in fats, it is vulnerable to
oxidation and inflammation - so it needs anti-
oxidant and anti-inflammatory protection.
Omega 3 fish oil makes healthy cell membranes
Anti-oxidant and anti-inflammatory nutrients: Omega 3, vitamins C and E, beta
carotene, curcumin and polyphenols like green tea and grapeseed extract
membrane

8. Because cell membranes have a high
unsaturated fat content they are very
vulnerable to free radical damage. Free
radical damage occurs when fats react with
oxygen – and you can see the process when a
fat like lard becomes rancid. The illustration
left represents how free radicals can attack
and damage a cell.
Nutrients that can provide protection are
called anti-oxidants. They create a “shield”
that “quenches” or absorbs free radicals.
There is evidence that polyphenols called
anthocyanins found in coloured berries – like
blueberries, bilberries, raspberries and black
currants - are especially powerful neuro-
protectors. They help protect brain cells.
Anti-oxidants neutralise free radical damage
Anti-oxidant and anti-inflammatory nutrients: Omega 3, vitamins C and E, beta
carotene, curcumin and polyphenols like green tea and grapeseed extract

9. Each cell membrane must do something else
that is vital. Cells need to sense each other’s
boundaries. They do that by what is called
‘cell signalling’. When they cannot signal their
boundaries, the result can be uncontrolled
cell growth – cancer.
Researchers have found that vitamin D, the
carotenoids lycopene and lutein and choline
are important to ensure normal cell signalling
and, by extension, cutting the risk of cancer.
Pub Med, the on-line publishing arm of the
American National Institutes of Health,
confirms that carotenoids ‘can be useful in
the prevention of cancer and other
degenerative diseases.’1
.
The importance of effective cell signalling
Nutrients that support normal cell signalling : vitamin D, lycopene, lutein and choline

10. Inside each cell are a nucleus and several
mitochondria - which are normally likened to
miniature ‘power plants’. Heart, brain and
muscle cells have the most mitochondria,
because they have high energy demands.
Inside mitochondria, the energy from food
is transferred to energy storage molecules
such as ATP. The nutrient Coenzyme Q10 or
CoQ10 is vital in this process. A lack of CoQ10
– which declines with age - is a cause of lack
of energy
Anti-oxidants are needed for protection
because oxidative damage to mitochondria is
contributes to accelerated ageing.
.
Protect your mitochondria
Nutrients that support your mitochondria and energy production: Co Q10, B vitamins,
vitamins C and E, magnesium, zinc, chromium, beta carotene, and polyphenols

11. During the continual process of cell replication,
mistakes and damage to DNA occasionally, but
inevitably, occur.
If a cell has accumulated a lot of DNA damage, it
can trigger the start of a cancerous tumour
where cells do not stop growing and dividing.
Researchers have discovered that selenium, zinc,
the carotenoids lutein and lycopene, and a
compound called isothiocyanate found in
cruciferous vegetables are among compounds
important in the DNA repair mechanism.
Cumulative DNA damage is thought to further
contribute to the ageing process, and is involved
in certain diseases including cancer.
Support your DNA repair mechanism
Nutrients that support DNA repair: lutein, lycopene, selenium, zinc and isothiocyanates

12. What is called ‘chronic, sub-clinical
inflammation’ is now known to be a major cause
of the degenerative killer diseases.
This type of inflammation builds up in tissues
over time, but you can’t see or feel it – which is
why Time Magazine calls it ‘the silent killer’.
New Scientist recently confirms it’s involved in:
…”muscle wasting and glaucoma, Alzheimer’s
and Parkinson’s, osteoporosis and arthritis, heart
failure and high blood pressure, cancers, and
lung, liver and kidney and skin disorders.”
Inflammation increases with age and affects
most people after the age of about 50. Risks rise
further if you are a city dweller exposed to air
pollution from particulates, living a low-energy
lifestyle and consuming processed foods.
4. Reverse ‘chronic’ inflammation

13. The body uses fatty acids from the food we eat
to make the hormones called eicosanoids that
control the inflammatory response.
Omega 6 fatty acids, found in polyunsaturated
plant oils like safflower, sunflower, palm and
corn oil, increase the level of hormones that
promote inflammation. These oils are frequently
used in processed foods because they are cheap.
They are also put into feeds for animals
intensively raised for meat consumption.
Omega 3 fatty acids (from oily fish) have the
opposite effect, producing eicosanoids that
reduce inflammation.
Processed foods often
contain excess levels of
pro-inflammatory Omega 6
Reduce pro-inflammatory foods
Reducing Omega 6 intake and increasing your Omega 3 intake
produces a healthier Omega 3/6 balance.

14. The American Cancer Institute now recommends
nine portions of fruits and vegetables a day!
Fruits and vegetables not only promote positive
gene expression, they contain, amongst other
compounds, flavonoids - polyphenol molecules.
These exert powerful anti-inflammatory effects
in the body.
Flavonoids also help block the potentially highly
destructive action of enzymes called MMPs
which are directly responsible for the tissue
damage that turns chronic inflammation into
overt disease – and creates an environment
where cancer can spread.
So increase your fruit and veg intake.
Increase anti-inflammatory foods
If 9 portions is a challenge, take a supplement that contains flavonoids
and plant derived nutrients like lycopene, lutein and grapeseed extract.

15. When cells are damaged by inflammation
they produce toxic compounds that
trigger the release of excess free radicals.
The resulting oxidative stress further
damages those cells, and this process
releases a second wave of inflammatory
compounds.
This vicious circle drives both
degenerative disease and the ageing
process itself.
That’s why your diet should contain high
levels of both anti-inflammatory and
anti-oxidant foods and nutrients.
Dark berry fruits, vegetables like kale, spinach, and broccoli and spices like turmeric
(curcumin) are all high in both anti-inflammatory and anti-oxidant compounds.
.
Inflammation and Free Radical damage – a vicious circle

16. If there is an excess of sugar in the body, protein
molecules can react with sugar molecules and
form cross-links with other proteins. This is
called glycation and once a protein is glycated it
is damaged and unable to perform its proper
function.
Collagen is the most abundant protein in the
body and when collagen is glycated the result is
reduced flexibility of organs, hardened arteries,
hypertension, impaired muscle function and
kidney damage. Externally it manifests as loss of
elasticity, wrinkles and accelerated skin ageing.
Internally excess glycation is linked to damage to
the lining of blood vessels (and hence heart
disease), the stiffening of the lens of the eye and
the formation of cataracts. Glycemic stress is
linked to Alzheimer’s and glycation contributes
to accelerated ageing.
5. Prevent ‘sugar coated’ cell damage
Normal skin has neat, regular
collagen bonds – a bit like
undamaged chainmail
When skin becomes glycated the
bonds in collagen become
irregular and cross-linked leading
to internal and external ageing.

17. Whole fruits – or liquidising whole fruits – are
better than fruit juices which are light in fibre
and heavy in fructose. And cut down on
confectionary and baked goods.
In addition, when foods containing proteins are
cooked at high temperatures, the protein binds
with sugars in the food to produce toxic pro-
inflammatory compounds.
Avoid deep-frying and grilling, including chips,
French fries and crisps, and many processed
foods which are often prepared using very high
temperatures. Prefer steaming and microwaving.
Reduce glycation
Spices like ginger, turmeric, thyme, rosemary and basil have an anti-
inflammatory effect and can help neutralise glycation. Include them in your
cooking. And rub meat to be grilled with rosemary or thyme.
.

18. Your immune system defends you against
pathogen invaders like viruses and bacteria and
against internal ‘rogue’ cells. Unfortunately it
declines in effectiveness as we age, which is why
extra support is important.
Foods that support the immune system include
mushrooms (especially shiitake and maitake
mushrooms), dark berry fruits, cabbage,
spinach, broccoli and kale, pumpkins, citrus
fruits for their vitamin C content, green tea,
garlic, and wheat germ which is high in
vitamin E.
6. Support your immune system
Nutrients that support the immune system: vitamins A, D and E selenium,
zinc, green tea extract, flavonoids, curcumin, beta carotene and lycopene.
.

19. If you have an illness like measles your Acquired
Immune System creates antibodies which
normally protect you from catching the same
illness again.
You also have a second (Innate) Immune System,
consisting of Natural Killer cells, macrophages
and neutrophils. These patrol the body and
normally neutralise the threats from viruses,
bacteria and ‘rogue cells’ by killing them.
A natural ingredient, called 1-3, 1-6 beta glucans
is proven to modulate the Innate Immune
System by increasing the number and activity
level of your Natural Killer cells.
When the Canadian Dept. of Defence tested
over 100 immune system enhancers, a 1-3. 1-6
beta glucan called Wellmune was the top rated.
A macrophage enveloping
and killing virus
Boosting your Innate Immune System

20. The microbes in your gut are called your
microbiome. These microbes make some
essential vitamins like B vitamins and Vitamin K.
They are also vital part of your immune system.
If the numbers and range of these ‘friendly’
microbes is reduced –for example if you are on
antibiotics or have a sub-optimal diet – you
become much more vulnerable to pathogens
like C difficile and salmonella.
Diseases as widely different as asthma, diabetes,
obesity, cancer, and heart disease have been
shown to be influenced by the microbiome.
If the microbiome is not properly nourished the
gut becomes more permeable which can allow
toxins to leak into the blood stream triggering
inflammation that affects the entire body.
7. Feed your 100 trillion ‘guest’ microbes!

21. Different gut microbes need different types
of ‘food’ to feed on and thrive.
These include prebiotic fibres found in
peas, beans, lentils, oats, in fibrous fruits
like figs, apples, dates, prunes and in
vegetables like asparagus, leeks, garlic,
onions, broccoli, cabbage and root
vegetables.
Your microbiome also benefits from
fermented probiotic foods like sauerkraut,
tempeh, buttermilk, sourdough bread and
miso soup.
You can boost the numbers and range of beneficial microbes by eating
probiotic yoghurts that contain strains of ‘friendly’ bacteria like L. plantarum
and Bifidobacteria and Akkermansia.
Ensuring a healthy microbiome

22. On average we are living longer – but too
often the later years are characterised by
illness.
We now know that the causes of these
illnesses are all interconnected. It looks
complicated but two common problems
underlie all of them. Lack of physical
activity and sub-optimal nutrition - because
your nutritional needs increase over time.
The solution then is clear. By increasing the
level of the foods and nutrients we have
highlighted in this presentation you can
dramatically reduce the risk and threat of
so-called ‘age related diseases’. And slow
biological ageing.
The 7 interconnected causes of ageing and illness

23. Summarised opposite is the simplest yet
most comprehensive plan to maximise your
health, counteract the threats that lead to
illness and slow biological ageing.
Achieving all 7 parts of the plan depends on
regular exercise and optimum nutrition:
• Increased intake of the fruits, vegetables
mushrooms, whole grains and nuts and a
reduced intake of refined grains, sugar and
processed foods. (Just because you’ve
heard it before, doesn’t make it less true!)
• Increased pre and pro-biotic foods
• Oily fish 3 times a week
• A nutritional supplement that includes the
range and level of nutrients that fully
supports this 7 step plan.
1. Promote positive gene
expression
2. Slow the reduction in
telomere length
3. Build healthy cells and
support DNA repair
4. Reduce internal chronic
inflammation
5. Reduce glycation
6. Support your immune
system
7. Feed your microbiome
The Seven Pillars of Health

24. Counteracting all seven causes of ageing
requires consistent levels of a wide range of
nutrients. And those needs increase over time.
(So the American Cancer Society recommends
9 portions of fruits and vegetables a day).
Yet the average person burns 1,000 calories a
day less than 60 years ago! So we’ve had to
reduce our calorie intake - but less food means
less nutrition.
To compound the problem, the nutritional value
of many foods has declined over the same
period.
A simple one-a-day A-Z vitamin pill might be
enough if you are under about 40. But it won’t
include the other nutrients that support the 7
pillars of health as you get older.
Why would you need a supplement?

25. Even a conscientious person will struggle to
obtain the range and levels of the preventative
nutrients we have identified, day-after-day.
In formulating Nutrishield we have drawn on
over 35 years and 10,000 peer reviewed studies
to design the combination of nutrients -in
optimum, synergistic and safe amounts - that
support the full, healthy functioning of brain and
body. It’s a heart, brain, skin, joint and eye
supplement all in one.
Coupled with a sensible diet and moderate
exercise, it gives you the foundation for long
term health and energy.
It works: independent tests show NutriShield
dramatically reduces inflammatory markers at
the cell level. And 87% of our customers come
from word of mouth recommendation.
The most comprehensive supplement
1. A full range of vitamins and minerals
2. Polyphenols that include curcumin,
green tea, bilberry and grapeseed
extract
3. Omega 3 fish oil
4. Lycopene, lutein and beta carotene
5. Glucosamine
6. CoQ 10
7. Soy isoflavones, genistein and betaine

26. Links
www.nutrishield.com
If you order today we will also send you a colour
cookbook that shows how to include the foods
discussed in this report.
www.immunoshield.com
includes Wellmune 1-3, 1-6 beta glucans
You will find articles and scientific references
for all the statements made
and nutrients mentioned at
www.nutrishield.com/the-library
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