Fungal infections occur when fungi invade areas of the body and overwhelm the immune system. There are several classes of antifungal drugs that target harmful fungi, including imidazoles, triazoles, allylamines, and polyene antibiotics. Imidazoles like miconazole and econazole damage the fungal cell membrane. Triazoles like fluconazole inhibit ergosterol synthesis. Allylamines such as terbinafine inhibit fungal cell membrane synthesis. Polyene antibiotics like amphotericin B and nystatin bind to ergosterol in the fungal cell membrane.

1. ANTI-FUNGAL AGENTS

2. Introduction:
 Fungal infections are common throughout much of the natural
world. In humans, fungal infections occur when an
invading fungus takes over an area of the body and is too
much for the immune system to handle.Fungi can live in
the air, soil, water, and plants. There are also some fungi
that live naturally in the human body.
 Like many microbes, there are helpful fungi and harmful
fungi. When harmful fungi invade the body, they can be
difficult to kill, as they can survive in the environment and
re-infect the person trying to get better.

3. Drug therapy for Fungal Infections
 I. Antifungals damaging permeability of the
cell membrane
 •Imidazoles:
 Bifonazole, Clotrimazole, Econazole,Ketoconazole,
Miconazole
 Triazoles:
 Fluconazole, Itraconazole, Voriconazole
 Allylamines:
 Terbinafine, Naftifine

4.  Morpholines:
 Amorolfine
 •Thiocarbamates:
 Tolciclate, Tolnaftate
 •Substituted pyridones:
 Ciclopirox
 •Polyene antibiotics:
 Amphotericin B, Nystatin

5.  II. Antifungals inhibiting chitin synthesis in
the cell wall
 •Caspofungin, Griseofulvin
 III. Antifungals inhibiting synthesis of nucleic
acids
 •Flucytosine

6. Imidazole
 Miconazole and Econazole
I. Antifungals damaging permeability of cell
membrane.

7. Synthesis of Miconazole and
econazole

8.  Clotrimazole

9. Triazoles
 Fluconazole

10. Allylamines
 Naftefine

11. Thiocarbamates
 Tolnaftate

12. Synthesis of Tolnaftate

13. Substituted Pyridones
 Ciclopirox

14. Synthesis of ciclopirox

15. Polyene Antibiotics
 Amphotericin B

16.  Nystatin

17. II. Anti fungals inhibiting chitin
synthesis in the cell wall
 Griseofulvin

18. III. Anti fungals inhibiting synthesis
of nucleic acids
 Flucytosine

20. THANK YOU.