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Thirty Years of HIV/AIDS;
Science and Leadership

     Carl W. Dieffenbach, Ph.D.
       Director, Division of AIDS,
              NIAID, NIH
            August 14, 2011
HIV Incidence Reduction by
                     Prevention Technologies
Study                                                                            Effect Size (95% CI)
ARV treatment for prevention                                                           96% (73-99)
PrEP for discordant couples                                                            73% (49-85)
PrEP for heterosexual men &                                                            63% (21-84)
women

Medical male circumcision                                                              54% (38-66)

PrEP for MSMs                                                                          44% (15-63)

Sexually transmitted diseases                                                          42% (21-58)
treatment

Microbicide                                                                            39% (6-60)

HIV vaccine                                                                            31% (1-51)

FEM-PrEP                                                                               0% (0-41)




                                0   10   20   30    40 50 60      70   80   90   100
                                                   Efficacy (%)
 Reducing HIV incidence
 Increasing access to
  care and optimizing health
  outcomes
 Reducing HIV-related
  health disparities

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30 Years of HIV/AIDS Science and Leadership

  • 1. Thirty Years of HIV/AIDS; Science and Leadership Carl W. Dieffenbach, Ph.D. Director, Division of AIDS, NIAID, NIH August 14, 2011
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  • 20. HIV Incidence Reduction by Prevention Technologies Study Effect Size (95% CI) ARV treatment for prevention 96% (73-99) PrEP for discordant couples 73% (49-85) PrEP for heterosexual men & 63% (21-84) women Medical male circumcision 54% (38-66) PrEP for MSMs 44% (15-63) Sexually transmitted diseases 42% (21-58) treatment Microbicide 39% (6-60) HIV vaccine 31% (1-51) FEM-PrEP 0% (0-41) 0 10 20 30 40 50 60 70 80 90 100 Efficacy (%)
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  • 25.  Reducing HIV incidence  Increasing access to care and optimizing health outcomes  Reducing HIV-related health disparities