ANTIDEPRESSANTS

1. ANTIDEPRESSANTS

2. HOW DO
ANTIDEPRESSANTS
WORK?
Work by balancing chemicals in your brain called neurotransmitters that
affect mood and emotions.

3. 1950
Discovered two
New drugs:
antidepressants

4. IPRONAIZID
• Was intended to treat tuberculosis
• In 1952 improved the modos of patients with
depression.
IMIPRAMINE
•Drug for allergic reactions
•In 1956: A Swiss clinician observed a similar
effect on patients with depression.

5. Both drugs affected a class of neurotransmitters called
monoamines
That depression is caused by having insufficient
monoamines.
The drugs were thought to restore that balance y
increasing the availability of monoamines in the brain.
DISCOVERY

6. What Side
Effects Do
Antidepressant
Cause?
 Drowsiness
 Reduced sex drive
 Dry mouth
 Weight gain
 Headache
 Agitation
 Nausea
 Sleeplessness

7. 1970S
One monoamine:
SEROTONIN

8. This Discovery led to the
production of fluxetina or Prozac
(1988)
Selective Serotonin Reuptake Inhibitors or SSRI’s
Prozac worked well and had fewer side effects

9. 1990S
The number of
people being
treated for
depression
skyrocketed.

10. BOTH WAYS
PSYCHOTHERAPY ANTIDEPRESSANT DRUGS