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Amphetamine
Md : Obydulla Al Mamun
Id:131-29-500
9th(B)
Department Of Pharmacy
Daffodil International University
almamundc...
Amphetamine
A distinct class of
drugs that stimulate
the central nervous
system producing an
increase in alertness,
wakef...
History of
Amphetamines
 1887 by German Pharmacologist L. Edeleano.
 In 1927, Gordon Alles:
 Reduced fatigue
 Increase...
Sources
Ephedra is the primary component used
to synthesize amphetamine.
Types of Amphetamines
 CNS stimulant
How Amphetamines Work
Therapeutic Uses
of Amphetamines
 Narcolepsy
 Attention Deficit Hyperactivity Disorder (ADHD)
Weight reduction
HyperkinesisHyperkinesisNarcolepsyNarcolepsy
Treatment
Weight Reduction
During 1960’s, 99% of
amphetamine Rx written for
weight loss.
 Effective for two weeks.
Lose weight, g...
Psychological Effects
Euphoria
Excitement
Mood elevation
 sed speech activity
Feeling of power
Psychological Effects
...
High Dose Users
 leading to extended mental and physical hyperactivity.
 Continued abuse (high doses) often leads to:
 ...
Summary of the Effects of Amphetamines
Body
 Increased heartbeat
 Increased blood
pressure
 Decreased appetite
 Increa...
• Acute overdose is treated by –
 Acidification of urine by administering ammonium
chloride. This increases rate of elimi...
Amphetamine.final.pptx
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Amphetamine.final.pptx

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Md : Obydulla Al Mamun
Id:131-29-500
9th(B)
Department Of Pharmacy
Daffodil International University
almamundcc94@gmail.com

Published in: Health & Medicine
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Amphetamine.final.pptx

  1. 1. Amphetamine Md : Obydulla Al Mamun Id:131-29-500 9th(B) Department Of Pharmacy Daffodil International University almamundcc94@gmail.com
  2. 2. Amphetamine A distinct class of drugs that stimulate the central nervous system producing an increase in alertness, wakefulness and awareness.
  3. 3. History of Amphetamines  1887 by German Pharmacologist L. Edeleano.  In 1927, Gordon Alles:  Reduced fatigue  Increased alertness  Caused a sense of confident euphoria  In 1932, Benzedrine inhalers (nasal congestion).  Benzedrine widely abused (1971) for their stimulant action.  Widely used in World War II to counter act fatigue.
  4. 4. Sources Ephedra is the primary component used to synthesize amphetamine.
  5. 5. Types of Amphetamines  CNS stimulant
  6. 6. How Amphetamines Work
  7. 7. Therapeutic Uses of Amphetamines  Narcolepsy  Attention Deficit Hyperactivity Disorder (ADHD) Weight reduction
  8. 8. HyperkinesisHyperkinesisNarcolepsyNarcolepsy
  9. 9. Treatment
  10. 10. Weight Reduction During 1960’s, 99% of amphetamine Rx written for weight loss.  Effective for two weeks. Lose weight, gain energy, good mood.
  11. 11. Psychological Effects Euphoria Excitement Mood elevation  sed speech activity Feeling of power Psychological Effects Euphoria Excitement Mood elevation  sed speech activity Feeling of power Pharmacological effectPharmacological effect Physiological Effects Increased BP Decreased HR Increased alertness Psychomotor stimulant Loss of appetite
  12. 12. High Dose Users  leading to extended mental and physical hyperactivity.  Continued abuse (high doses) often leads to:  Considerable weight loss  Skin lesions  Oral damage  Liver disease  Hypertensive disorders  Stroke  Kidney damage  Seizures
  13. 13. Summary of the Effects of Amphetamines Body  Increased heartbeat  Increased blood pressure  Decreased appetite  Increased breathing rate  Inability to sleep  Sweating  Convulsions, fever  Chest pain  Irregular heartbeat Due to overdose Mind Decreased fatigue Increased confidence Increased feeling of alertness Restlessness Increased irritability Fearfulness Distrust of people Behavioral stereotypy Hallucination low dose high dose
  14. 14. • Acute overdose is treated by –  Acidification of urine by administering ammonium chloride. This increases rate of elimination of amphetamine.  Anti-hypertensive drugs like labetelol.  Treatment typically requires more than one year of Intense intervention consisting of drug abstinence, cognitive, emotional and motivational rehabilitation. Treatment Of Acute Poisoning

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