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Elvitegravir

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AnitaKrasniqi4

Poster prezantimi

Health & Medicine
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ELVITEGRAVIR Indikacioni  Trajtimin e infeksionit HIV-1 Mekanizmi i veprimit Frenues i transferimit të fijes integrale që pengon integrimin e ADN-së HIV-1 në ADN-n gjenomike dhe bllokon formimin e provirusit. Lidhja për proteinë Forma farmaceutike Tabletë 98-99% Absorbimi Pas administrimit oral përqëndrimet në plazmë arrihen pas 4h Metabolizimi I nënshtrohet metabolizimit oksidativ përmes CYP3A në mëlqi Rruga e eliminimit Renal 7% Mëlqi 93% Gjysëm jeta Afërsishtë 8.7-13.7h Toksiciteti Nauze,vjellje dhe diarre dhimbje barku,lodhje ,pagjumësi Ndërveprimet Warfarin,Abemaciclib, Albendazol,Aldosteron, Vaksina e Adenovirusit, Acetokumarol

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Elvitegravir

  • 1. ELVITEGRAVIR Indikacioni  Trajtimin e infeksionit HIV-1 Mekanizmi i veprimit Frenues i transferimit të fijes integrale që pengon integrimin e ADN-së HIV-1 në ADN-n gjenomike dhe bllokon formimin e provirusit. Lidhja për proteinë Forma farmaceutike Tabletë 98-99% Absorbimi Pas administrimit oral përqëndrimet në plazmë arrihen pas 4h Metabolizimi I nënshtrohet metabolizimit oksidativ përmes CYP3A në mëlqi Rruga e eliminimit Renal 7% Mëlqi 93% Gjysëm jeta Afërsishtë 8.7-13.7h Toksiciteti Nauze,vjellje dhe diarre dhimbje barku,lodhje ,pagjumësi Ndërveprimet Warfarin,Abemaciclib, Albendazol,Aldosteron, Vaksina e Adenovirusit, Acetokumarol